Bioreactors for Tendon Constructs

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureHoofdstukAcademicpeer review

Samenvatting

Tendon injuries are very frequent and are often repaired with autografts, allografts, xenografts, or tissue-engineered tendon grafts. With the rising field of tissue engineering, bioreactors became useful tools. Bioreactors are devices in which biological and/or biochemical processes can be recreated in a highly controlled in vitro culture environment. Using these bioreactors, it is possible to study tendon physiology and pathophysiology but also the mechanical and biological factors that regulate tendon formation, homeostasis, or degeneration. Currently, bioreactors are also used to create novel tissue-engineered constructs for clinical applications or as in vitro model systems to predict in vivo outcomes of engineered constructs. In this chapter, bioreactors that provide the possibility for applying mechanical loading to tendon constructs will be discussed, together with the ways in which these bioreactors are used and can be used.

Originele taal-2Engels
Titel3D Printing and Bioprinting for Pharmaceutical and Medical Applications
UitgeverijCRC Press
Pagina's245-276
Aantal pagina's32
ISBN van elektronische versie9781000957549
ISBN van geprinte versie9781032228662
DOI's
StatusGepubliceerd - 1 jan. 2023

Bibliografische nota

Publisher Copyright:
© 2024 selection and editorial matter, Jose Luis Pedraz Muñoz, Laura Saenz del Burgo Martínez, Gustavo Puras Ochoa, Jon Zarate Sesma; individual chapters, the contributors.

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