Biomechanics and modeling of tissue-engineered heart valves

Tommaso Ristori, A.J. (Mathieu) van Kelle, Frank Baaijens, Sandra Loerakker

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureHoofdstukAcademic

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Samenvatting

Heart valve tissue engineering (HVTE) is a promising technique to overcome the limitations of currently available heart valve prostheses. However, before clinical use, still several challenges need to be overcome. The functionality of the developed replacements is determined by their biomechanical properties and, ultimately, by their collagen architecture. Unfortunately, current techniques are often not able to induce a physiological tissue remodeling, which compromises the long-term functionality. Therefore, a deeper understanding of the process of tissue remodeling is required to optimize the phenomena involved via improving the current HVTE approaches. Computational simulations can help in this process, being a valuable and versatile tool to predict and understand experimental results. This chapter first describes the similarities and differences in functionality and biomechanical properties between native and tissue-engineered heart valves. Secondly, the current status of computational models for collagen remodeling is addressed and, finally, future directions and implications for HVTE are suggested.
Originele taal-2Engels
TitelAdvances in heart valve biomechanics
Subtitelvalvular physiology, mechanobiology, and bioengineering
RedacteurenMichael Sacks, Jun Liao
Plaats van productieCham
UitgeverijSpringer
Hoofdstuk16
Pagina's413-446
Aantal pagina's34
ISBN van elektronische versie978-3-030-01993-8
ISBN van geprinte versie978-3-030-01991-4
DOI's
StatusGepubliceerd - 8 apr 2019

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Ristori, T., van Kelle, A. J. M., Baaijens, F., & Loerakker, S. (2019). Biomechanics and modeling of tissue-engineered heart valves. In M. Sacks, & J. Liao (editors), Advances in heart valve biomechanics: valvular physiology, mechanobiology, and bioengineering (blz. 413-446). Cham: Springer. https://doi.org/10.1007/978-3-030-01993-8_16