Biomaterial-driven kidney organoid maturation

Johnick F. van Sprang; Simone M.J. de Jong; Patricia Y.W. Dankers

doi:10.1016/j.cobme.2021.100355

Biomaterial-driven kidney organoid maturation

Johnick F. van Sprang
, Simone M.J. de Jong
, Patricia Y.W. Dankers (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

8 Citaten (Scopus)

216 Downloads (Pure)

Samenvatting

Differentiation of human-induced pluripotent stem cells (hiPSCs) toward kidney organoids is known to suffer from batch-to-batch differences, off-target populations, and skewered cellular compositions. Application of synthetic hydrogels as a tool for hiPSC-differentiation may provide additional control over this variable process. This review discusses important material properties that affect kidney organoid generation. We summarize cellular adhesive cues for synthetic materials, that allow transduction of the mechanical forces to the cell, and how these signals directly affect Hippo-Canonical Wnt signaling and morphogenic events. In addition, chemical strategies are discussed that allow spatiotemporal presentation of biochemical agents to the cell in a material-dependent approach.

Originele taal-2	Engels
Artikelnummer	100355
Aantal pagina's	10
Tijdschrift	Current Opinion in Biomedical Engineering
Volume	21
DOI's	https://doi.org/10.1016/j.cobme.2021.100355
Status	Gepubliceerd - mrt. 2022

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Publisher Copyright:
© 2021 The Authors

Financiering

This work was funded by the Ministry of Education, Culture and Science (Gravity Programs 024.001.035 and 024.003.013), by the partners of Regenerative Medicine Crossing Borders (RegMed XB) powered by Health∼Holland , Top Sector Life Sciences & Health , and a NWO VIDI grant from the Netherlands Organization for Scientific Research (NWO, 723.016.008). The figures were made with BioRender software.

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10.1016/j.cobme.2021.100355

published versionDefinitieve gepubliceerde versie, 1,5 MBLicentie: CC BY

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@article{56390f2d145f418a99bc7769297961a7,

title = "Biomaterial-driven kidney organoid maturation",

abstract = "Differentiation of human-induced pluripotent stem cells (hiPSCs) toward kidney organoids is known to suffer from batch-to-batch differences, off-target populations, and skewered cellular compositions. Application of synthetic hydrogels as a tool for hiPSC-differentiation may provide additional control over this variable process. This review discusses important material properties that affect kidney organoid generation. We summarize cellular adhesive cues for synthetic materials, that allow transduction of the mechanical forces to the cell, and how these signals directly affect Hippo-Canonical Wnt signaling and morphogenic events. In addition, chemical strategies are discussed that allow spatiotemporal presentation of biochemical agents to the cell in a material-dependent approach.",

keywords = "Biomaterials, hiPSC, Kidney organoids",

author = "\{van Sprang\}, \{Johnick F.\} and \{de Jong\}, \{Simone M.J.\} and Dankers, \{Patricia Y.W.\}",

note = "Funding Information: This work was funded by the Ministry of Education, Culture and Science (Gravity Programs 024.001.035 and 024.003.013), by the partners of Regenerative Medicine Crossing Borders (RegMed XB) powered by Health∼Holland , Top Sector Life Sciences \& Health , and a NWO VIDI grant from the Netherlands Organization for Scientific Research (NWO, 723.016.008). The figures were made with BioRender software. ",

year = "2022",

month = mar,

doi = "10.1016/j.cobme.2021.100355",

language = "English",

volume = "21",

journal = "Current Opinion in Biomedical Engineering",

issn = "2468-4511",

publisher = "Elsevier",

}

TY - JOUR

T1 - Biomaterial-driven kidney organoid maturation

AU - van Sprang, Johnick F.

AU - de Jong, Simone M.J.

AU - Dankers, Patricia Y.W.

N1 - Funding Information: This work was funded by the Ministry of Education, Culture and Science (Gravity Programs 024.001.035 and 024.003.013), by the partners of Regenerative Medicine Crossing Borders (RegMed XB) powered by Health∼Holland , Top Sector Life Sciences & Health , and a NWO VIDI grant from the Netherlands Organization for Scientific Research (NWO, 723.016.008). The figures were made with BioRender software.

PY - 2022/3

Y1 - 2022/3

N2 - Differentiation of human-induced pluripotent stem cells (hiPSCs) toward kidney organoids is known to suffer from batch-to-batch differences, off-target populations, and skewered cellular compositions. Application of synthetic hydrogels as a tool for hiPSC-differentiation may provide additional control over this variable process. This review discusses important material properties that affect kidney organoid generation. We summarize cellular adhesive cues for synthetic materials, that allow transduction of the mechanical forces to the cell, and how these signals directly affect Hippo-Canonical Wnt signaling and morphogenic events. In addition, chemical strategies are discussed that allow spatiotemporal presentation of biochemical agents to the cell in a material-dependent approach.

AB - Differentiation of human-induced pluripotent stem cells (hiPSCs) toward kidney organoids is known to suffer from batch-to-batch differences, off-target populations, and skewered cellular compositions. Application of synthetic hydrogels as a tool for hiPSC-differentiation may provide additional control over this variable process. This review discusses important material properties that affect kidney organoid generation. We summarize cellular adhesive cues for synthetic materials, that allow transduction of the mechanical forces to the cell, and how these signals directly affect Hippo-Canonical Wnt signaling and morphogenic events. In addition, chemical strategies are discussed that allow spatiotemporal presentation of biochemical agents to the cell in a material-dependent approach.

KW - Biomaterials

KW - hiPSC

KW - Kidney organoids

UR - https://www.scopus.com/pages/publications/85121628472

U2 - 10.1016/j.cobme.2021.100355

DO - 10.1016/j.cobme.2021.100355

M3 - Review article

AN - SCOPUS:85121628472

SN - 2468-4511

VL - 21

JO - Current Opinion in Biomedical Engineering

JF - Current Opinion in Biomedical Engineering

M1 - 100355

ER -

Biomaterial-driven kidney organoid maturation

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