TY - JOUR
T1 - Biomaterial-driven kidney organoid maturation
AU - van Sprang, Johnick F.
AU - de Jong, Simone M.J.
AU - Dankers, Patricia Y.W.
N1 - Funding Information:
This work was funded by the Ministry of Education, Culture and Science (Gravity Programs 024.001.035 and 024.003.013), by the partners of Regenerative Medicine Crossing Borders (RegMed XB) powered by Health∼Holland , Top Sector Life Sciences & Health , and a NWO VIDI grant from the Netherlands Organization for Scientific Research (NWO, 723.016.008). The figures were made with BioRender software.
PY - 2022/3
Y1 - 2022/3
N2 - Differentiation of human-induced pluripotent stem cells (hiPSCs) toward kidney organoids is known to suffer from batch-to-batch differences, off-target populations, and skewered cellular compositions. Application of synthetic hydrogels as a tool for hiPSC-differentiation may provide additional control over this variable process. This review discusses important material properties that affect kidney organoid generation. We summarize cellular adhesive cues for synthetic materials, that allow transduction of the mechanical forces to the cell, and how these signals directly affect Hippo-Canonical Wnt signaling and morphogenic events. In addition, chemical strategies are discussed that allow spatiotemporal presentation of biochemical agents to the cell in a material-dependent approach.
AB - Differentiation of human-induced pluripotent stem cells (hiPSCs) toward kidney organoids is known to suffer from batch-to-batch differences, off-target populations, and skewered cellular compositions. Application of synthetic hydrogels as a tool for hiPSC-differentiation may provide additional control over this variable process. This review discusses important material properties that affect kidney organoid generation. We summarize cellular adhesive cues for synthetic materials, that allow transduction of the mechanical forces to the cell, and how these signals directly affect Hippo-Canonical Wnt signaling and morphogenic events. In addition, chemical strategies are discussed that allow spatiotemporal presentation of biochemical agents to the cell in a material-dependent approach.
KW - Biomaterials
KW - hiPSC
KW - Kidney organoids
UR - http://www.scopus.com/inward/record.url?scp=85121628472&partnerID=8YFLogxK
U2 - 10.1016/j.cobme.2021.100355
DO - 10.1016/j.cobme.2021.100355
M3 - Review article
AN - SCOPUS:85121628472
SN - 2468-4511
VL - 21
JO - Current Opinion in Biomedical Engineering
JF - Current Opinion in Biomedical Engineering
M1 - 100355
ER -