Biologically active polymersomes from amphiphilic glycopeptides

J. Huang, C. Bonduelle, J. Thevenot, S. Lecommandoux, A. Heise

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

207 Citaten (Scopus)
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Samenvatting

Polypeptide block copolymers with different block length ratios were obtained by sequential ring-opening polymerization of benzyl-L-glutamate and propargylglycine (PG) N-carboxyanhydrides. Glycosylation of the poly(PG) block was obtained by Huisgens cycloaddition "click" reaction using azide-functionalized galactose. All copolymers were self-assembled using the nanoprecipitation method to obtain spherical and wormlike micelles as well as polymersomes depending on the block length ratio and the nanoprecipitation conditions. These structures display bioactive galactose units in the polymersome shell, as proven by selective lectin binding experiments
Originele taal-2Engels
Pagina's (van-tot)119-122
TijdschriftJournal of the American Chemical Society
Volume134
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - 2012

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