Biodegradable polymersomes with structure Inherent fluorescence and targeting capacity for enhanced photo-dynamic therapy

Shoupeng Cao, Yifeng Xia, Jingxin Shao, Beibei Guo, Yangyang Dong, Imke A.B. Pijpers, Zhiyuan Zhong, Fenghua Meng (Corresponding author), Loai K.E.A. Abdelmohsen (Corresponding author), David S. Williams (Corresponding author), Jan C.M. van Hest (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

3 Citaten (Scopus)
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Samenvatting

Biodegradable nanostructures displaying aggregation-induced emission (AIE) are desirable from a biomedical point of view, due to the advantageous features of loading capacity, emission brightness, and fluorescence stability. Herein, biodegradable polymers comprising poly (ethylene glycol)-block-poly(caprolactone-gradient-trimethylene carbonate) (PEG-P(CLgTMC)), with tetraphenylethylene pyridinium-TMC (PAIE) side chains have been developed, which self-assembled into well-defined polymersomes. The resultant AIEgenic polymersomes are intrinsically fluorescent delivery vehicles. The presence of the pyridinium moiety endows the polymersomes with mitochondrial targeting ability, which improves the efficiency of co-encapsulated photosensitizers and improves therapeutic index against cancer cells both in vitro and in vivo. This contribution showcases the ability to engineer AIEgenic polymersomes with structure inherent fluorescence and targeting capacity for enhanced photodynamic therapy.

Originele taal-2Engels
Pagina's (van-tot)17629-17637
Aantal pagina's9
TijdschriftAngewandte Chemie - International Edition
Volume60
Nummer van het tijdschrift32
DOI's
StatusGepubliceerd - 2 aug 2021

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Publisher Copyright:
© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH

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