Biodegradable fibre scaffolds incorporating water-soluble drugs and proteins

J. Ma, J. Meng, M. Simonet, N. Stingelin, T. Peijs, G.B. Sukhorukov

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

9 Citaten (Scopus)

Samenvatting

A new type of biodegradable drug-loaded fibre scaffold has been successfully produced for the benefit of water-soluble drugs and proteins. Model drug loaded calcium carbonate (CaCO3) microparticles incorporated into poly(lactic acid-co-glycolic acid) (PLGA) fibres were manufactured by co-precipitation of CaCO3 and the drug molecules, followed by electrospinning of a suspension of such drug-loaded microparticles in a PLGA solution. Rhodamine 6G and bovine serum albumin were used as model drugs for our release study, representing small bioactive molecules and protein, respectively. A bead and string structure of fibres was achieved. The drug release was investigated with different drug loadings and in different pH release mediums. Results showed that a slow and sustained drug release was achieved in 40 days and the CaCO3 microparticles used as the second barrier restrained the initial burst release.
Originele taal-2Engels
Artikelnummer205
Pagina's (van-tot)1-9
TijdschriftJournal of Materials Science: Materials in Medicine
Volume26
Nummer van het tijdschrift7
DOI's
StatusGepubliceerd - 2015

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