Bio-inks for 3D bioprinting: recent advances and future prospects

I. Donderwinkel, J.C.M. van Hest, N.R. Cameron

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

105 Citaten (Scopus)

Samenvatting

In the last decade, interest in the field of three-dimensional (3D) bioprinting has increased enormously. 3D bioprinting combines the fields of developmental biology, stem cells, and computer and materials science to create complex bio-hybrid structures for various applications. It is able to precisely place different cell types, biomaterials and biomolecules together in a predefined position to generate printed composite architectures. In the field of tissue engineering, 3D bioprinting has allowed the study of tissues and organs on a new level. In clinical applications, new models have been generated to study disease pathogenesis. One of the most important components of 3D bio-printing is the bio-ink, which is a mixture of cells, biomaterials and bioactive molecules that creates the printed article. This review describes all the currently used bio-printing inks, including polymeric hydrogels, polymer bead microcarriers, cell aggregates and extracellular matrix proteins. Amongst the polymeric components in bio-inks are: natural polymers including gelatin, hyaluronic acid, silk proteins and elastin; and synthetic polymers including amphiphilic block copolymers, PEG, poly(PNIPAAM) and polyphosphazenes. Furthermore, photocrosslinkable and thermoresponsive materials are described. To provide readers with an understanding of the context, the review also contains an overview of current bio-printing techniques and finishes with a summary of bio-printing applications.

Originele taal-2Engels
Pagina's (van-tot)4451-4471
Aantal pagina's21
TijdschriftPolymer Chemistry
Volume8
Nummer van het tijdschrift31
DOI's
StatusGepubliceerd - 20 aug 2017

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