Bilayer deformation, pores, and micellation induced by oxidized lipids

Ph. Boonnoy, V. Jarerattanachat, M.E.J. Karttunen, J. Wong-Ekkabut

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

41 Citaten (Scopus)

Samenvatting

The influence of different oxidized lipids on lipid bilayers was investigated with 16 individual 1 μs atomistic molecular dynamics (MD) simulations. Binary mixtures of lipid bilayers of 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholine (PLPC) and its peroxide and aldehyde products were performed at different concentrations. In addition, an asymmetrical short chain lipid, 1-palmitoyl-2-decanoyl-sn-glycero-3-phosphatidylcholine (PDPC), was used to compare the effects of polar/apolar groups in the lipid tail on lipid bilayer. Although water defects occurred with both aldehyde and peroxide lipids, full pore formation was observed only for aldehyde lipids. At medium concentrations the pores were stable. At higher concentrations, however, the pores became unstable and micellation occurred. Data analysis shows that aldehyde lipids' propensity for pore formation is due to their shorter and highly mobile tail. The highly polar peroxide lipids are stabilized by strong hydrogen bonds with interfacial water.

Originele taal-2Engels
Pagina's (van-tot)4884-4888
Aantal pagina's5
TijdschriftThe Journal of Physical Chemistry Letters
Volume6
Nummer van het tijdschrift24
DOI's
StatusGepubliceerd - 24 nov 2015

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