B/A Measurement of Clear Cell Renal Cell Carcinoma versus Healthy Kidney Tissue

Anastasiia Panfilova (Corresponding author), Xufei Chen, Christiaan Widdershoven, Jan Erik Freund, Dilara Savci Heijink, Patricia Zondervan, Ruud J.G. van Sloun, Oleg A. Sapozhnikov, Hessel Wijkstra, Massimo Mischi

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

1 Citaat (Scopus)
40 Downloads (Pure)

Samenvatting

The acoustic parameter of non-linearity B/A has been found capable of discriminating some types of pathological tissue from healthy tissue. The literature on the utility of B/A for cancer diagnostics is very limited, with measurements on the human breast and liver. This work expands the current research on cancer diagnostics by B/A assessment of eight slices of human clear cell renal cell carcinoma (ccRCC) from two patients and four slices of healthy kidney tissue from two healthy kidney samples. The Wilcoxon test identified the B/A distribution of malignant tissue as not significantly different from that of healthy tissue. An alternative way of defining outliers resulted in median B/A values of 8.1 for ccRCC and 6.8 for healthy tissue (p < 0.05). Acoustic attenuation at 2.1 MHz was significantly greater (p < 0.05) for ccRCC (1.7 dB/cm) than for healthy tissue (1.0 dB/cm). The observed differences in the measured values suggest that B/A and acoustic attenuation may represent potential diagnostic markers of ccRCC. More data and an improved experimental design are required to provide a definitive conclusion on the utility of B/A for cancer diagnostics.

Originele taal-2Engels
Pagina's (van-tot)1348-1355
Aantal pagina's8
TijdschriftUltrasound in Medicine and Biology
Volume48
Nummer van het tijdschrift7
DOI's
StatusGepubliceerd - jul. 2022

Bibliografische nota

Publisher Copyright:
© 2022 The Authors

Financiering

This research was supported by the Eindhoven MedTech Innovation Center and in part by the Russian Science Foundation under Grant No. 19-12-00148 (O.A.S.).

Vingerafdruk

Duik in de onderzoeksthema's van 'B/A Measurement of Clear Cell Renal Cell Carcinoma versus Healthy Kidney Tissue'. Samen vormen ze een unieke vingerafdruk.

Citeer dit