Au-Mesoporous silica nanoparticles gated with disulfide-linked oligo(ethylene glycol) chains for tunable cargo delivery mediated by an integrated enzymatic control unit

Antoni Llopis-Lorente, Beatriz De Luis, Alba García-Fernández, Paula Díez, Alfredo Sánchez, M. Dolores Marcos, Reynaldo Villalonga, Ramón Martínez-Máñez, Félix Sancenón

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

12 Citaten (Scopus)

Samenvatting

We report a delivery system based on Au-mesoporous silica (MS) nanoparticles functionalized with acetylcholinesterase on the Au face as a control unit and with disulfide-containing oligo(ethylene glycol) chains on the MS face as caps. The control unit handles the chemical information in the environment (the presence of acetylthiocholine or enzyme inhibitors) that results in a tuned cargo delivery from the nanocarrier. The nanodevice displayed an enhanced cargo delivery in cancer cells (safranin O and doxorubicin) in the presence of acetylthiocholine.

Originele taal-2Engels
Pagina's (van-tot)6734-6739
Aantal pagina's6
TijdschriftJournal of Materials Chemistry B
Volume5
Nummer van het tijdschrift33
DOI's
StatusGepubliceerd - 7 sep 2017
Extern gepubliceerdJa

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