Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings

James J.P. Alix; Christoph Neuwirth; Lucy Gelder; Christian Burkhardt; José Castro; Mamede de Carvalho; Malgorzata Gawel; Stephan Goedee; Julian Grosskreutz; Timothée Lenglet; Cristina Moglia; Taha Omer; Maarten Schrooten; Sanjeev Nandedkar; Erik Stalberg; Paul E. Barkhaus; Jasna Furtula; Johannes P. van Dijk; Reto Baldinger; Joao Costa; Marit Otto; Arne Sandberg; Markus Weber

doi:10.1016/j.clinph.2019.01.020

Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings

James J.P. Alix (Corresponding author), Christoph Neuwirth, Lucy Gelder, Christian Burkhardt, José Castro, Mamede de Carvalho, Malgorzata Gawel, Stephan Goedee, Julian Grosskreutz, Timothée Lenglet, Cristina Moglia, Taha Omer, Maarten Schrooten, Sanjeev Nandedkar, Erik Stalberg, Paul E. Barkhaus, Jasna Furtula, Johannes P. van Dijk, Reto Baldinger, Joao CostaMarit Otto, Arne Sandberg, Markus Weber

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

14 Citaten (Scopus)

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OBJECTIVE: The motor unit size index (MUSIX) is incorporated into the motor unit number index (MUNIX). Our objective was to assess the intra-/inter-rater reliability of MUSIX in healthy volunteers across single subject "round robin" and multi-centre settings.

METHODS: Data were obtained from (i) a round-robin assessment in which 12 raters (6 with prior experience and 6 without) assessed six muscles (abductor pollicis brevis, abductor digiti minimi, biceps brachii, tibialis anterior, extensor digitorum brevis and abductor hallucis) and (ii) a multi-centre study with 6 centres studying the same muscles in 66 healthy volunteers. Intra/inter-rater data were provided by 5 centres, 1 centre provided only intra-rater data. Intra/inter-rater variability was assessed using the coefficient of variation (COV), Bland-Altman plots, bias and 95% limits of agreement.

RESULTS: In the round-robin assessment intra-rater COVs for MUSIX ranged from 7.8% to 28.4%. Inter-rater variability was between 7.8% and 16.2%. Prior experience did not impact on MUSIX values. In the multi-centre study MUSIX was more consistent than the MUNIX. Abductor hallucis was the least reliable muscle.

CONCLUSIONS: The MUSIX is a reliable neurophysiological biomarker of reinnervation.

SIGNIFICANCE: MUSIX could provide insights into the pathophysiology of a range of neuromuscular disorders, providing a quantitative biomarker of reinnervation.

Originele taal-2	Engels
Pagina's (van-tot)	666-674
Aantal pagina's	9
Tijdschrift	Clinical Neurophysiology
Volume	130
Nummer van het tijdschrift	5
DOI's	https://doi.org/10.1016/j.clinph.2019.01.020
Status	Gepubliceerd - mei 2019

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10.1016/j.clinph.2019.01.020

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Alix, J. J. P., Neuwirth, C., Gelder, L., Burkhardt, C., Castro, J., de Carvalho, M., Gawel, M., Goedee, S., Grosskreutz, J., Lenglet, T., Moglia, C., Omer, T., Schrooten, M., Nandedkar, S., Stalberg, E., Barkhaus, P. E., Furtula, J., van Dijk, J. P., Baldinger, R., ... Weber, M. (2019). Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings. Clinical Neurophysiology, 130(5), 666-674. https://doi.org/10.1016/j.clinph.2019.01.020

@article{de8ae88ef23845a18a6c789f7b7f94c3,

title = "Assessment of the reliability of the motor unit size index (MUSIX) in single subject {"}round-robin{"} and multi-centre settings",

abstract = "OBJECTIVE: The motor unit size index (MUSIX) is incorporated into the motor unit number index (MUNIX). Our objective was to assess the intra-/inter-rater reliability of MUSIX in healthy volunteers across single subject {"}round robin{"} and multi-centre settings.METHODS: Data were obtained from (i) a round-robin assessment in which 12 raters (6 with prior experience and 6 without) assessed six muscles (abductor pollicis brevis, abductor digiti minimi, biceps brachii, tibialis anterior, extensor digitorum brevis and abductor hallucis) and (ii) a multi-centre study with 6 centres studying the same muscles in 66 healthy volunteers. Intra/inter-rater data were provided by 5 centres, 1 centre provided only intra-rater data. Intra/inter-rater variability was assessed using the coefficient of variation (COV), Bland-Altman plots, bias and 95% limits of agreement.RESULTS: In the round-robin assessment intra-rater COVs for MUSIX ranged from 7.8% to 28.4%. Inter-rater variability was between 7.8% and 16.2%. Prior experience did not impact on MUSIX values. In the multi-centre study MUSIX was more consistent than the MUNIX. Abductor hallucis was the least reliable muscle.CONCLUSIONS: The MUSIX is a reliable neurophysiological biomarker of reinnervation.SIGNIFICANCE: MUSIX could provide insights into the pathophysiology of a range of neuromuscular disorders, providing a quantitative biomarker of reinnervation.",

author = "Alix, {James J.P.} and Christoph Neuwirth and Lucy Gelder and Christian Burkhardt and Jos{\'e} Castro and {de Carvalho}, Mamede and Malgorzata Gawel and Stephan Goedee and Julian Grosskreutz and Timoth{\'e}e Lenglet and Cristina Moglia and Taha Omer and Maarten Schrooten and Sanjeev Nandedkar and Erik Stalberg and Barkhaus, {Paul E.} and Jasna Furtula and {van Dijk}, {Johannes P.} and Reto Baldinger and Joao Costa and Marit Otto and Arne Sandberg and Markus Weber",

year = "2019",

month = may,

doi = "10.1016/j.clinph.2019.01.020",

language = "English",

volume = "130",

pages = "666--674",

journal = "Clinical Neurophysiology",

issn = "1388-2457",

publisher = "Elsevier Ireland Ltd",

number = "5",

}

Alix, JJP, Neuwirth, C, Gelder, L, Burkhardt, C, Castro, J, de Carvalho, M, Gawel, M, Goedee, S, Grosskreutz, J, Lenglet, T, Moglia, C, Omer, T, Schrooten, M, Nandedkar, S, Stalberg, E, Barkhaus, PE, Furtula, J, van Dijk, JP, Baldinger, R, Costa, J, Otto, M, Sandberg, A & Weber, M 2019, 'Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings', Clinical Neurophysiology, vol. 130, nr. 5, blz. 666-674. https://doi.org/10.1016/j.clinph.2019.01.020

Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings. / Alix, James J.P. (Corresponding author); Neuwirth, Christoph; Gelder, Lucy et al.
In: Clinical Neurophysiology, Vol. 130, Nr. 5, 05.2019, blz. 666-674.

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

TY - JOUR

T1 - Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings

AU - Alix, James J.P.

AU - Neuwirth, Christoph

AU - Gelder, Lucy

AU - Burkhardt, Christian

AU - Castro, José

AU - de Carvalho, Mamede

AU - Gawel, Malgorzata

AU - Goedee, Stephan

AU - Grosskreutz, Julian

AU - Lenglet, Timothée

AU - Moglia, Cristina

AU - Omer, Taha

AU - Schrooten, Maarten

AU - Nandedkar, Sanjeev

AU - Stalberg, Erik

AU - Barkhaus, Paul E.

AU - Furtula, Jasna

AU - van Dijk, Johannes P.

AU - Baldinger, Reto

AU - Costa, Joao

AU - Otto, Marit

AU - Sandberg, Arne

AU - Weber, Markus

PY - 2019/5

Y1 - 2019/5

N2 - OBJECTIVE: The motor unit size index (MUSIX) is incorporated into the motor unit number index (MUNIX). Our objective was to assess the intra-/inter-rater reliability of MUSIX in healthy volunteers across single subject "round robin" and multi-centre settings.METHODS: Data were obtained from (i) a round-robin assessment in which 12 raters (6 with prior experience and 6 without) assessed six muscles (abductor pollicis brevis, abductor digiti minimi, biceps brachii, tibialis anterior, extensor digitorum brevis and abductor hallucis) and (ii) a multi-centre study with 6 centres studying the same muscles in 66 healthy volunteers. Intra/inter-rater data were provided by 5 centres, 1 centre provided only intra-rater data. Intra/inter-rater variability was assessed using the coefficient of variation (COV), Bland-Altman plots, bias and 95% limits of agreement.RESULTS: In the round-robin assessment intra-rater COVs for MUSIX ranged from 7.8% to 28.4%. Inter-rater variability was between 7.8% and 16.2%. Prior experience did not impact on MUSIX values. In the multi-centre study MUSIX was more consistent than the MUNIX. Abductor hallucis was the least reliable muscle.CONCLUSIONS: The MUSIX is a reliable neurophysiological biomarker of reinnervation.SIGNIFICANCE: MUSIX could provide insights into the pathophysiology of a range of neuromuscular disorders, providing a quantitative biomarker of reinnervation.

AB - OBJECTIVE: The motor unit size index (MUSIX) is incorporated into the motor unit number index (MUNIX). Our objective was to assess the intra-/inter-rater reliability of MUSIX in healthy volunteers across single subject "round robin" and multi-centre settings.METHODS: Data were obtained from (i) a round-robin assessment in which 12 raters (6 with prior experience and 6 without) assessed six muscles (abductor pollicis brevis, abductor digiti minimi, biceps brachii, tibialis anterior, extensor digitorum brevis and abductor hallucis) and (ii) a multi-centre study with 6 centres studying the same muscles in 66 healthy volunteers. Intra/inter-rater data were provided by 5 centres, 1 centre provided only intra-rater data. Intra/inter-rater variability was assessed using the coefficient of variation (COV), Bland-Altman plots, bias and 95% limits of agreement.RESULTS: In the round-robin assessment intra-rater COVs for MUSIX ranged from 7.8% to 28.4%. Inter-rater variability was between 7.8% and 16.2%. Prior experience did not impact on MUSIX values. In the multi-centre study MUSIX was more consistent than the MUNIX. Abductor hallucis was the least reliable muscle.CONCLUSIONS: The MUSIX is a reliable neurophysiological biomarker of reinnervation.SIGNIFICANCE: MUSIX could provide insights into the pathophysiology of a range of neuromuscular disorders, providing a quantitative biomarker of reinnervation.

U2 - 10.1016/j.clinph.2019.01.020

DO - 10.1016/j.clinph.2019.01.020

M3 - Article

C2 - 30870802

SN - 1388-2457

VL - 130

SP - 666

EP - 674

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

IS - 5

ER -

Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings

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