Samenvatting
We consider 2 problems of increasing importance in clinical dose finding studies. First, we assess the similarity of 2 non-linear regression models for 2 non-overlapping subgroups of patients over a restricted covariate space. To this end, we derive a confidence interval for the maximum difference between the 2 given models. If this confidence interval excludes the pre-specified equivalence margin, similarity of dose response can be claimed. Second, we address the problem of demonstrating the similarity of 2 target doses for 2 non-overlapping subgroups, using again an approach based on a confidence interval. We illustrate the proposed methods with a real case study and investigate their operating characteristics (coverage probabilities, Type I error rates, power) via simulation.
Originele taal-2 | Engels |
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Pagina's (van-tot) | 722-738 |
Aantal pagina's | 17 |
Tijdschrift | Statistics in Medicine |
Volume | 37 |
Nummer van het tijdschrift | 5 |
DOI's | |
Status | Gepubliceerd - 28 feb. 2018 |
Extern gepubliceerd | Ja |