TY - JOUR
T1 - Assembly of dynamic supramolecular polymers on a DNA origami platform
AU - Schill, Jurgen
AU - Rosier, Bas
AU - Gumí Audenis, Berta
AU - Magdalena Estirado, Eva
AU - de Greef, Tom
AU - Brunsveld, Luc
N1 - © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
PY - 2021/3/29
Y1 - 2021/3/29
N2 - Biological processes rely on transient interactions that govern assembly of biomolecules into higher order, multi-component systems. A synthetic platform for the dynamic assembly of multicomponent complexes would provide novel entries to study and modulate the assembly of artificial systems into higher order topologies. Here, we establish a hybrid DNA origami-based approach as an assembly platform that enables dynamic templating of supramolecular architectures. It entails the site-selective recruitment of supramolecular polymers to the platform with preservation of the intrinsic dynamics and reversibility of the assembly process. The composition of the supramolecular assembly on the platform can be tuned dynamically, allowing for monomer rearrangement and inclusion of molecular cargo. This work should aid the study of supramolecular structures in their native environment in real-time and incites new strategies for controlled multicomponent self-assembly of synthetic building blocks.
AB - Biological processes rely on transient interactions that govern assembly of biomolecules into higher order, multi-component systems. A synthetic platform for the dynamic assembly of multicomponent complexes would provide novel entries to study and modulate the assembly of artificial systems into higher order topologies. Here, we establish a hybrid DNA origami-based approach as an assembly platform that enables dynamic templating of supramolecular architectures. It entails the site-selective recruitment of supramolecular polymers to the platform with preservation of the intrinsic dynamics and reversibility of the assembly process. The composition of the supramolecular assembly on the platform can be tuned dynamically, allowing for monomer rearrangement and inclusion of molecular cargo. This work should aid the study of supramolecular structures in their native environment in real-time and incites new strategies for controlled multicomponent self-assembly of synthetic building blocks.
KW - multicomponent assembly
KW - polymers
KW - self-assembly
KW - supramolecular synthesis
UR - http://www.scopus.com/inward/record.url?scp=85101599059&partnerID=8YFLogxK
U2 - 10.1002/anie.202016244
DO - 10.1002/anie.202016244
M3 - Article
C2 - 33444471
VL - 60
SP - 7612
EP - 7616
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 0570-0833
IS - 14
ER -