Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex-vivo human skin model

Michel Verhoeven, S.N. Bystrova, L. Winnubst, H. Qureshi, T.D. Gruijl, de, R.J. Scheper, R. Luttge

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Nanoporous microneedle arrays from Al 2O 3 were fabricated via a micromolding process using a PDMS mold generated via a double replication process from a SU-8/Si-master as a template. Hg-porosity measurements showed that the porosity obtained was a function of the temperature used for sintering, resulting in an average pore diameter of 80 nm between 1300 and 1500 °C. Using egg plants it was shown that these nanoporous needles allowed both the delivery of substances, and the extraction of compounds. Subsequently, the delivery of compounds has been evaluated in an ex vivo human skin model using a microneedle array saturated with a labeled monoclonal against a specific marker, DC-SIGN, which is representative for dendritic cells when activated by an antigen. By the latter, it was demonstrated that ceramic nanoporous microneedle arrays are potentially useful for the delivery of vaccines. © 2012 Elsevier B.V. All rights reserved.
Originele taal-2Engels
Pagina's (van-tot)659-662
Aantal pagina's4
TijdschriftMicroelectronic Engineering
Volume98
DOI's
StatusGepubliceerd - 2012
Extern gepubliceerdJa

Vingerafdruk

eggs
delivery
Skin
Porosity
ceramics
porosity
Vaccines
Antigens
Needles
vaccines
Sintering
antigens
needles
markers
sintering
templates
direct current
cells
Temperature
temperature

Citeer dit

Verhoeven, Michel ; Bystrova, S.N. ; Winnubst, L. ; Qureshi, H. ; Gruijl, de, T.D. ; Scheper, R.J. ; Luttge, R. / Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex-vivo human skin model. In: Microelectronic Engineering. 2012 ; Vol. 98. blz. 659-662.
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title = "Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex-vivo human skin model",
abstract = "Nanoporous microneedle arrays from Al 2O 3 were fabricated via a micromolding process using a PDMS mold generated via a double replication process from a SU-8/Si-master as a template. Hg-porosity measurements showed that the porosity obtained was a function of the temperature used for sintering, resulting in an average pore diameter of 80 nm between 1300 and 1500 °C. Using egg plants it was shown that these nanoporous needles allowed both the delivery of substances, and the extraction of compounds. Subsequently, the delivery of compounds has been evaluated in an ex vivo human skin model using a microneedle array saturated with a labeled monoclonal against a specific marker, DC-SIGN, which is representative for dendritic cells when activated by an antigen. By the latter, it was demonstrated that ceramic nanoporous microneedle arrays are potentially useful for the delivery of vaccines. {\circledC} 2012 Elsevier B.V. All rights reserved.",
author = "Michel Verhoeven and S.N. Bystrova and L. Winnubst and H. Qureshi and {Gruijl, de}, T.D. and R.J. Scheper and R. Luttge",
year = "2012",
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Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex-vivo human skin model. / Verhoeven, Michel; Bystrova, S.N.; Winnubst, L.; Qureshi, H.; Gruijl, de, T.D.; Scheper, R.J.; Luttge, R.

In: Microelectronic Engineering, Vol. 98, 2012, blz. 659-662.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

TY - JOUR

T1 - Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex-vivo human skin model

AU - Verhoeven, Michel

AU - Bystrova, S.N.

AU - Winnubst, L.

AU - Qureshi, H.

AU - Gruijl, de, T.D.

AU - Scheper, R.J.

AU - Luttge, R.

PY - 2012

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N2 - Nanoporous microneedle arrays from Al 2O 3 were fabricated via a micromolding process using a PDMS mold generated via a double replication process from a SU-8/Si-master as a template. Hg-porosity measurements showed that the porosity obtained was a function of the temperature used for sintering, resulting in an average pore diameter of 80 nm between 1300 and 1500 °C. Using egg plants it was shown that these nanoporous needles allowed both the delivery of substances, and the extraction of compounds. Subsequently, the delivery of compounds has been evaluated in an ex vivo human skin model using a microneedle array saturated with a labeled monoclonal against a specific marker, DC-SIGN, which is representative for dendritic cells when activated by an antigen. By the latter, it was demonstrated that ceramic nanoporous microneedle arrays are potentially useful for the delivery of vaccines. © 2012 Elsevier B.V. All rights reserved.

AB - Nanoporous microneedle arrays from Al 2O 3 were fabricated via a micromolding process using a PDMS mold generated via a double replication process from a SU-8/Si-master as a template. Hg-porosity measurements showed that the porosity obtained was a function of the temperature used for sintering, resulting in an average pore diameter of 80 nm between 1300 and 1500 °C. Using egg plants it was shown that these nanoporous needles allowed both the delivery of substances, and the extraction of compounds. Subsequently, the delivery of compounds has been evaluated in an ex vivo human skin model using a microneedle array saturated with a labeled monoclonal against a specific marker, DC-SIGN, which is representative for dendritic cells when activated by an antigen. By the latter, it was demonstrated that ceramic nanoporous microneedle arrays are potentially useful for the delivery of vaccines. © 2012 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.mee.2012.07.022

DO - 10.1016/j.mee.2012.07.022

M3 - Article

VL - 98

SP - 659

EP - 662

JO - Microelectronic Engineering

JF - Microelectronic Engineering

SN - 0167-9317

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