Analysis of retinal vascular biomarkers for early detection of diabetes

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This paper presents an automated retinal vessel analysis system for the measurement and statistical analysis of vascular biomarkers. The proposed retinal vessel enhancement, segmentation, optic disc and fovea detection algorithms provide fundamental tools for extracting the vascular network within the predefined region of interest (ROI). Based on that, the artery/vein classification, vessel caliber, curvature and fractal dimension measurement tools are used to assess the quantitative vascular biomarkers: width, tortuosity, and fractal dimension. A statistical analysis on the extracted geometric biomarkers is set up using a dataset provided by the Maastricht study with the aim of exploring the associations between different vessel biomarkers and type 2 diabetes mellitus. A linear regression analysis is used to model the relationships between different factors. The results indicate that the vascular biomarker variables have associations with diabetes. These findings demonstrate the possibility of applying the proposed pipeline tools on further analysis of vessel biomarkers for the computer-aided diagnosis.
Originele taal-2Engels
TitelViPIMAGE 2017
SubtitelProceedings of the VI ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing Porto, Portugal, October 18-20, 2017
RedacteurenJ.M.R.S. Tavares, R.M. Natal Jorge
Plaats van productieCham
Aantal pagina's7
ISBN van elektronische versie978-3-319-68195-5
ISBN van geprinte versie978-3-319-68194-8
StatusGepubliceerd - 1 jan. 2018
EvenementEuropean Congress on Computational Methods in Applied Sciences and Engineering, ECCOMAS 2017 - Porto, Portugal
Duur: 18 okt. 201720 okt. 2017

Publicatie series

NaamLecture Notes in Computational Vision and Biomechanics


CongresEuropean Congress on Computational Methods in Applied Sciences and Engineering, ECCOMAS 2017
Verkorte titelECCOMAS 2017
Internet adres


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