An actuator chip for in vitro mechano-stimuli responsive studies of primary cortical cell networks

S. Xie, J.G.E. Gardeniers, R. Luttge

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

1 Citaat (Scopus)

Uittreksel

To investigate the hypothesis that dynamic nanoscale stimuli can influence central nerve systems functioning, in this paper we develop a chip based on polydimethylsiloxane (PDMS) soft lithography which exerts nanoscale mechanical loads on an in vitro neuronal network by microfluidic pneumatic deformation of a membrane. Initial analysis on Calcium ion (Ca2+) imaging within rat primary cortical networks shows increased Ca2+activities in the neuronal network after a stimuli was introduced, indicating that the neuronal networks respond to the mechanical stimulus.

Originele taal-2Engels
Titel20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
UitgeverijChemical and Biological Microsystems Society
Pagina's495-496
Aantal pagina's2
ISBN van elektronische versie978-0-9798064-9-0
StatusGepubliceerd - 2016
Evenement20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) - Convention Center Dublin Spencer Dock, North Wall Quay Dublin 1 IRELAND, Dublin, Ierland
Duur: 9 okt 201613 okt 2016
Congresnummer: 20
http://www.microtasconferences.org/microtas2016/
http://www.microtas2016.org/

Congres

Congres20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)
Verkorte titelMicroTAS
LandIerland
StadDublin
Periode9/10/1613/10/16
Internet adres

Vingerafdruk

Polydimethylsiloxane
Microfluidics
Pneumatics
Lithography
Rats
Calcium
Actuators
Membranes
Imaging techniques
Ions

Citeer dit

Xie, S., Gardeniers, J. G. E., & Luttge, R. (2016). An actuator chip for in vitro mechano-stimuli responsive studies of primary cortical cell networks. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 (blz. 495-496). [M045b] Chemical and Biological Microsystems Society.
Xie, S. ; Gardeniers, J.G.E. ; Luttge, R. / An actuator chip for in vitro mechano-stimuli responsive studies of primary cortical cell networks. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. blz. 495-496
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Xie, S, Gardeniers, JGE & Luttge, R 2016, An actuator chip for in vitro mechano-stimuli responsive studies of primary cortical cell networks. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016., M045b, Chemical and Biological Microsystems Society, blz. 495-496, Dublin, Ierland, 9/10/16.

An actuator chip for in vitro mechano-stimuli responsive studies of primary cortical cell networks. / Xie, S.; Gardeniers, J.G.E.; Luttge, R.

20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, 2016. blz. 495-496 M045b.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

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AU - Gardeniers, J.G.E.

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Xie S, Gardeniers JGE, Luttge R. An actuator chip for in vitro mechano-stimuli responsive studies of primary cortical cell networks. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society. 2016. blz. 495-496. M045b