TY - JOUR
T1 - Alendronate-functionalized poly(2-oxazoline)s with tunable affinity for calcium cations
AU - Sánchez-Fernández, María J.
AU - Immers, Mikey R.
AU - Félix Lanao, Rosa P.
AU - Yang, Fang
AU - Bender, Johan C.M.E.
AU - Mecinović, Jasmin
AU - Leeuwenburgh, Sander C.G.
AU - van Hest, Jan C.M.
PY - 2019/8/12
Y1 - 2019/8/12
N2 - A library of poly(2-oxazoline)s functionalized with controllable amounts of alendronate, hydroxyl, and carboxylic acid side groups was successfully synthesized to create novel polymers with tunable affinity for calcium cations. The affinity of alendronate-containing polymers for calcium cations was quantified using isothermal titration calorimetry. Thermodynamic measurements revealed that the Ca2+-binding affinity of these polymers increased linearly with the amount of alendronate functionalization, up to values (KCa 2+ = 2.4 × 105 M-1) that were about 120-fold higher than those for previously reported polymers. The calcium-binding capacity of alendronate-functionalized poly(2-oxazoline)s was exploited to form robust hydrogel networks cross-linked using reversible physical bonds. Oscillatory rheology showed that these hydrogels recovered more than 100% of their initial storage modulus after severe network destruction. The versatile synthesis of alendronate-functionalized polymers and their strong and tunable affinity for calcium cations render these polymers promising candidates for various biomedical applications.
AB - A library of poly(2-oxazoline)s functionalized with controllable amounts of alendronate, hydroxyl, and carboxylic acid side groups was successfully synthesized to create novel polymers with tunable affinity for calcium cations. The affinity of alendronate-containing polymers for calcium cations was quantified using isothermal titration calorimetry. Thermodynamic measurements revealed that the Ca2+-binding affinity of these polymers increased linearly with the amount of alendronate functionalization, up to values (KCa 2+ = 2.4 × 105 M-1) that were about 120-fold higher than those for previously reported polymers. The calcium-binding capacity of alendronate-functionalized poly(2-oxazoline)s was exploited to form robust hydrogel networks cross-linked using reversible physical bonds. Oscillatory rheology showed that these hydrogels recovered more than 100% of their initial storage modulus after severe network destruction. The versatile synthesis of alendronate-functionalized polymers and their strong and tunable affinity for calcium cations render these polymers promising candidates for various biomedical applications.
UR - http://www.scopus.com/inward/record.url?scp=85070681270&partnerID=8YFLogxK
U2 - 10.1021/acs.biomac.9b00104
DO - 10.1021/acs.biomac.9b00104
M3 - Article
C2 - 31365234
AN - SCOPUS:85070681270
SN - 1525-7797
VL - 20
SP - 2913
EP - 2921
JO - Biomacromolecules
JF - Biomacromolecules
IS - 8
ER -