Aldevron accelerates growth using operations research in biomanufacturing

T.G. Martagan (Corresponding author), Y. Limon (Corresponding author), A. Krishnamurthy (Corresponding author), T. Foti (Corresponding author), P.A. Leland (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Uittreksel

In the biomanufacturing industry, production and planning decisions are often challenging because of batch-to-batch variability and uncertainty in the production yield, quality, cost, and lead times. To improve biomanufacturing efficiency, a multidisciplinary team of researchers collaborated over five years to develop a portfolio of decision support tools. The tools developed provide a data-driven, operations research–based approach to reduce biomanufacturing costs and lead times. These decision support tools comprise multiple deterministic and stochastic optimization models to optimize production and planning decisions. To optimize production decisions related to fermentation and protein purification, optimization tools were developed to provide a decision support mechanism that links the underlying biological and chemical processes with business risks and financial trade-offs. To optimize planning decisions, interactive scheduling and capacity planning tools were developed to enable efficient use of expensive and limited resources. Although developed in collaboration with Aldevron, these tools address common industry challenges, and they have been shared with a wider industry community through working group sessions.
TaalEngels
Pagina's137-153
TijdschriftInterfaces
Volume49
Nummer van het tijdschrift2
DOI's
StatusGepubliceerd - apr 2019

Vingerafdruk

Operations research
Planning
Industry
Fermentation
Purification
Costs
Scheduling
Proteins
Decision support

Citeer dit

Martagan, T. G., Limon, Y., Krishnamurthy, A., Foti, T., & Leland, P. A. (2019). Aldevron accelerates growth using operations research in biomanufacturing. Interfaces, 49(2), 137-153. DOI: 10.1287/inte.2018.0984
Martagan, T.G. ; Limon, Y. ; Krishnamurthy, A. ; Foti, T. ; Leland, P.A./ Aldevron accelerates growth using operations research in biomanufacturing. In: Interfaces. 2019 ; Vol. 49, Nr. 2. blz. 137-153
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Martagan, TG, Limon, Y, Krishnamurthy, A, Foti, T & Leland, PA 2019, 'Aldevron accelerates growth using operations research in biomanufacturing' Interfaces, vol. 49, nr. 2, blz. 137-153. DOI: 10.1287/inte.2018.0984

Aldevron accelerates growth using operations research in biomanufacturing. / Martagan, T.G. (Corresponding author); Limon, Y. (Corresponding author); Krishnamurthy, A. (Corresponding author); Foti, T. (Corresponding author); Leland, P.A. (Corresponding author).

In: Interfaces, Vol. 49, Nr. 2, 04.2019, blz. 137-153.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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Martagan TG, Limon Y, Krishnamurthy A, Foti T, Leland PA. Aldevron accelerates growth using operations research in biomanufacturing. Interfaces. 2019 apr;49(2):137-153. Beschikbaar vanaf, DOI: 10.1287/inte.2018.0984