Aerobic C-H olefination of indoles via a cross-dehydrogenative coupling in continuous flow

H.P.L. Gemoets, V. Hessel, T. Noel

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Samenvatting

Herein, we report the first site-selective, Pd(II)-catalyzed, cross-dehydrogenative Heck reaction of indoles in micro flow. By use of a capillary microreactor, we were able to boost the intrinsic kinetics to accelerate former hour-scale reaction conditions in batch to the minute range in flow. The synergistic use of microreactor technology and oxygen, as both terminal oxidant and mixing motif, highlights the sustainable aspect of this process
Originele taal-2Engels
TitelChains, Chemistry As Innovating Science 2014, 17-18 November 2014, Veldhoven, The Netherlands
StatusGepubliceerd - 2014
EvenementCHAINS 2014 (CHemistry As Innovating Science) - Koningshof, Veldhoven, Nederland
Duur: 17 nov 201418 nov 2014
http://www.chains2014.nl/

Congres

CongresCHAINS 2014 (CHemistry As Innovating Science)
Verkorte titelCHAINS 2014
LandNederland
StadVeldhoven
Periode17/11/1418/11/14
AnderChemistry As Innovating Science 2014 (CHAINS 2014)
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