Activation instead of inhibition: targeting proenzymes for small-molecule intervention

Christian Ottmann; Patrick Hauske; Markus Kaiser

doi:10.1002/cbic.201000024

Activation instead of inhibition: targeting proenzymes for small-molecule intervention

Christian Ottmann, Patrick Hauske, Markus Kaiser (Corresponding author)

Chemical Biology

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

8 Citaten (Scopus)

1 Downloads (Pure)

Samenvatting

Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has recently be achieved for procaspase‐3. This success opens up new possibilities for small‐molecule intervention in biology, and reveals proenzymes as a whole new class of potential targets.

Originele taal-2	Engels
Pagina's (van-tot)	637-639
Aantal pagina's	3
Tijdschrift	ChemBioChem
Volume	11
Nummer van het tijdschrift	5
DOI's	https://doi.org/10.1002/cbic.201000024
Status	Gepubliceerd - 22 mrt. 2010

Toegang tot document

10.1002/cbic.201000024

Citeer dit

@article{e13e57699b254bdf8c00f889cabcb282,

title = "Activation instead of inhibition: targeting proenzymes for small-molecule intervention",

abstract = "Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has recently be achieved for procaspase‐3. This success opens up new possibilities for small‐molecule intervention in biology, and reveals proenzymes as a whole new class of potential targets.",

keywords = "Benzamides/chemistry, Caspase 3/chemistry, Catalytic Domain, Coumarins/chemistry, Enzyme Precursors/chemistry, Hydrazones/chemistry, Piperazines/chemistry, Protein Binding, Protein Structure, Tertiary",

author = "Christian Ottmann and Patrick Hauske and Markus Kaiser",

year = "2010",

month = mar,

day = "22",

doi = "10.1002/cbic.201000024",

language = "English",

volume = "11",

pages = "637--639",

journal = "ChemBioChem",

issn = "1439-4227",

publisher = "Wiley-VCH Verlag",

number = "5",

}

TY - JOUR

T1 - Activation instead of inhibition

T2 - targeting proenzymes for small-molecule intervention

AU - Ottmann, Christian

AU - Hauske, Patrick

AU - Kaiser, Markus

PY - 2010/3/22

Y1 - 2010/3/22

N2 - Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has recently be achieved for procaspase‐3. This success opens up new possibilities for small‐molecule intervention in biology, and reveals proenzymes as a whole new class of potential targets.

AB - Switching on pro‐proteases: Direct small‐molecule activation of proenzymes such as pro‐proteases has recently be achieved for procaspase‐3. This success opens up new possibilities for small‐molecule intervention in biology, and reveals proenzymes as a whole new class of potential targets.

KW - Benzamides/chemistry

KW - Caspase 3/chemistry

KW - Catalytic Domain

KW - Coumarins/chemistry

KW - Enzyme Precursors/chemistry

KW - Hydrazones/chemistry

KW - Piperazines/chemistry

KW - Protein Binding

KW - Protein Structure, Tertiary

U2 - 10.1002/cbic.201000024

DO - 10.1002/cbic.201000024

M3 - Article

C2 - 20143368

SN - 1439-4227

VL - 11

SP - 637

EP - 639

JO - ChemBioChem

JF - ChemBioChem

IS - 5

ER -

Activation instead of inhibition: targeting proenzymes for small-molecule intervention

Samenvatting

Toegang tot document

Vingerafdruk

Citeer dit