Action-based analysis of discrete regulatory networks with short-term stimuli

C. Krause, E.P. Vink, de

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1 Citaat (Scopus)

Samenvatting

To incorporate instant effects and different timescales within a single biological system, an extension of discrete regulatory networks with short-term stimuli is proposed. By maintaining a vector of recent changes, activities initiated by a steep increase or decrease can be captured in a qualitative setting. In order to compensate for the blow-up due to enhanced states, we focus on observable behavior. Identification of bisimilar states yields a compact system representation truthfully expressing the information relevant for deciding logical properties. The approach is implemented by means of a front-end to the mCRL2 tool set and illustrated for the switching of bacteriophage lambda and a bio-medical case study related to TGFß driven fibrotic conditions.
Originele taal-2Engels
TitelProceedings of the 8th Conference on Computational Methods in Systems Biology (CMSB 2010, Trento, Italy, September 29-October 1, 2010)
RedacteurenP. Quaglia
Plaats van productieNew York NY
UitgeverijAssociation for Computing Machinery, Inc
Pagina's65-75
ISBN van geprinte versie978-1-4503-0068-1
DOI's
StatusGepubliceerd - 2010
Evenementconference; The 8th Conference on Computational Methods in Systems Biology (CMSB 2010); 2010-09-29; 2010-10-01 -
Duur: 29 sep 20101 okt 2010

Congres

Congresconference; The 8th Conference on Computational Methods in Systems Biology (CMSB 2010); 2010-09-29; 2010-10-01
Periode29/09/101/10/10
AnderThe 8th Conference on Computational Methods in Systems Biology (CMSB 2010)

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