Abnormal profiles of local functional connectivity proximal to focal cortical dysplasias

R.M.H. Besseling, J.F.A. Jansen, A.J.A. de Louw, M.C.G. Vlooswijk, M.C. Hoeberigs, A.P. Aldenkamp, W.H. Backes, P.A.M. Hofman

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INTRODUCTION: Focal cortical dysplasia (FCD) is a congenital malformation of cortical development that often leads to medically refractory epilepsy. Focal resection can be an effective treatment, but is challenging as the surgically relevant abnormality may exceed the MR-visible lesion. The aim of the current study is to develop methodology to characterize the profile of functional connectivity around FCDs using resting-state functional MRI and in the individual patient. The detection of aberrant connectivity may provide a means to more completely delineate the clinically relevant lesion.

MATERIALS AND METHODS: Fifteen FCD patients (age, mean±SD: 31±11 years; 11 males) and 16 matched healthy controls (35±9 years; 7 males) underwent structural and functional imaging at 3 Tesla. The cortical surface was reconstructed from the T1-weighted scan and the registered functional MRI data was spatially normalized to a common anatomical standard space employing the gyral pattern. Seed-based functional connectivity was determined in all subjects for all dysplasia locations. A single patient was excluded based on an aberrant FCD seed time series. Functional connectivity as a function of geodesic distance (along the cortical surface) was compared between the individual patients and the homotopic normative connectivity profiles derived from the controls.

RESULTS: In 12/14 patients, aberrant profiles of functional connectivity were found, which demonstrated both hyper- and hypoconnectivity as well as combinations. Abnormal functional connectivity was typically found (also) beyond the lesion visible on structural MRI, while functional connectivity profiles not related to a lesion appeared normal in patients.

CONCLUSION: This novel functional MRI technique has potential for delineating functionally aberrant from normal cortex beyond the structural lesion in FCD, which remains to be confirmed in future research.

TaalEngels
Artikelnummere0166022
Aantal pagina's15
TijdschriftPLoS ONE
Volume11
Nummer van het tijdschrift11
DOI's
StatusGepubliceerd - 2016

Vingerafdruk

Malformations of Cortical Development
Magnetic Resonance Imaging
lesions (animal)
Seed
lesions (plant)
Seeds
Refractory materials
congenital abnormalities
Time series
epilepsy
resection
seeds
Imaging techniques
time series analysis
Epilepsy
cortex
image analysis
methodology

Citeer dit

Besseling, R.M.H. ; Jansen, J.F.A. ; de Louw, A.J.A. ; Vlooswijk, M.C.G. ; Hoeberigs, M.C. ; Aldenkamp, A.P. ; Backes, W.H. ; Hofman, P.A.M./ Abnormal profiles of local functional connectivity proximal to focal cortical dysplasias. In: PLoS ONE. 2016 ; Vol. 11, Nr. 11.
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title = "Abnormal profiles of local functional connectivity proximal to focal cortical dysplasias",
abstract = "INTRODUCTION: Focal cortical dysplasia (FCD) is a congenital malformation of cortical development that often leads to medically refractory epilepsy. Focal resection can be an effective treatment, but is challenging as the surgically relevant abnormality may exceed the MR-visible lesion. The aim of the current study is to develop methodology to characterize the profile of functional connectivity around FCDs using resting-state functional MRI and in the individual patient. The detection of aberrant connectivity may provide a means to more completely delineate the clinically relevant lesion.MATERIALS AND METHODS: Fifteen FCD patients (age, mean±SD: 31±11 years; 11 males) and 16 matched healthy controls (35±9 years; 7 males) underwent structural and functional imaging at 3 Tesla. The cortical surface was reconstructed from the T1-weighted scan and the registered functional MRI data was spatially normalized to a common anatomical standard space employing the gyral pattern. Seed-based functional connectivity was determined in all subjects for all dysplasia locations. A single patient was excluded based on an aberrant FCD seed time series. Functional connectivity as a function of geodesic distance (along the cortical surface) was compared between the individual patients and the homotopic normative connectivity profiles derived from the controls.RESULTS: In 12/14 patients, aberrant profiles of functional connectivity were found, which demonstrated both hyper- and hypoconnectivity as well as combinations. Abnormal functional connectivity was typically found (also) beyond the lesion visible on structural MRI, while functional connectivity profiles not related to a lesion appeared normal in patients.CONCLUSION: This novel functional MRI technique has potential for delineating functionally aberrant from normal cortex beyond the structural lesion in FCD, which remains to be confirmed in future research.",
author = "R.M.H. Besseling and J.F.A. Jansen and {de Louw}, A.J.A. and M.C.G. Vlooswijk and M.C. Hoeberigs and A.P. Aldenkamp and W.H. Backes and P.A.M. Hofman",
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Besseling, RMH, Jansen, JFA, de Louw, AJA, Vlooswijk, MCG, Hoeberigs, MC, Aldenkamp, AP, Backes, WH & Hofman, PAM 2016, 'Abnormal profiles of local functional connectivity proximal to focal cortical dysplasias' PLoS ONE, vol. 11, nr. 11, e0166022. DOI: 10.1371/journal.pone.0166022

Abnormal profiles of local functional connectivity proximal to focal cortical dysplasias. / Besseling, R.M.H.; Jansen, J.F.A.; de Louw, A.J.A.; Vlooswijk, M.C.G.; Hoeberigs, M.C.; Aldenkamp, A.P.; Backes, W.H.; Hofman, P.A.M.

In: PLoS ONE, Vol. 11, Nr. 11, e0166022, 2016.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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T1 - Abnormal profiles of local functional connectivity proximal to focal cortical dysplasias

AU - Besseling,R.M.H.

AU - Jansen,J.F.A.

AU - de Louw,A.J.A.

AU - Vlooswijk,M.C.G.

AU - Hoeberigs,M.C.

AU - Aldenkamp,A.P.

AU - Backes,W.H.

AU - Hofman,P.A.M.

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N2 - INTRODUCTION: Focal cortical dysplasia (FCD) is a congenital malformation of cortical development that often leads to medically refractory epilepsy. Focal resection can be an effective treatment, but is challenging as the surgically relevant abnormality may exceed the MR-visible lesion. The aim of the current study is to develop methodology to characterize the profile of functional connectivity around FCDs using resting-state functional MRI and in the individual patient. The detection of aberrant connectivity may provide a means to more completely delineate the clinically relevant lesion.MATERIALS AND METHODS: Fifteen FCD patients (age, mean±SD: 31±11 years; 11 males) and 16 matched healthy controls (35±9 years; 7 males) underwent structural and functional imaging at 3 Tesla. The cortical surface was reconstructed from the T1-weighted scan and the registered functional MRI data was spatially normalized to a common anatomical standard space employing the gyral pattern. Seed-based functional connectivity was determined in all subjects for all dysplasia locations. A single patient was excluded based on an aberrant FCD seed time series. Functional connectivity as a function of geodesic distance (along the cortical surface) was compared between the individual patients and the homotopic normative connectivity profiles derived from the controls.RESULTS: In 12/14 patients, aberrant profiles of functional connectivity were found, which demonstrated both hyper- and hypoconnectivity as well as combinations. Abnormal functional connectivity was typically found (also) beyond the lesion visible on structural MRI, while functional connectivity profiles not related to a lesion appeared normal in patients.CONCLUSION: This novel functional MRI technique has potential for delineating functionally aberrant from normal cortex beyond the structural lesion in FCD, which remains to be confirmed in future research.

AB - INTRODUCTION: Focal cortical dysplasia (FCD) is a congenital malformation of cortical development that often leads to medically refractory epilepsy. Focal resection can be an effective treatment, but is challenging as the surgically relevant abnormality may exceed the MR-visible lesion. The aim of the current study is to develop methodology to characterize the profile of functional connectivity around FCDs using resting-state functional MRI and in the individual patient. The detection of aberrant connectivity may provide a means to more completely delineate the clinically relevant lesion.MATERIALS AND METHODS: Fifteen FCD patients (age, mean±SD: 31±11 years; 11 males) and 16 matched healthy controls (35±9 years; 7 males) underwent structural and functional imaging at 3 Tesla. The cortical surface was reconstructed from the T1-weighted scan and the registered functional MRI data was spatially normalized to a common anatomical standard space employing the gyral pattern. Seed-based functional connectivity was determined in all subjects for all dysplasia locations. A single patient was excluded based on an aberrant FCD seed time series. Functional connectivity as a function of geodesic distance (along the cortical surface) was compared between the individual patients and the homotopic normative connectivity profiles derived from the controls.RESULTS: In 12/14 patients, aberrant profiles of functional connectivity were found, which demonstrated both hyper- and hypoconnectivity as well as combinations. Abnormal functional connectivity was typically found (also) beyond the lesion visible on structural MRI, while functional connectivity profiles not related to a lesion appeared normal in patients.CONCLUSION: This novel functional MRI technique has potential for delineating functionally aberrant from normal cortex beyond the structural lesion in FCD, which remains to be confirmed in future research.

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