TY - JOUR
T1 - A versatile protocol for studying anterior cruciate ligament reconstruction in a rabbit model
AU - Hevesi, Mario
AU - Crispim, João F
AU - Paggi, Carlo A.
AU - Dudakovic, Amel
AU - van Genechten, Wouter
AU - Hewett, Timothy
AU - Kakar, Sanjeev
AU - Krych, Aaron J.
AU - van Wijnen, Andre J
AU - Saris, Daniel
PY - 2019/3/19
Y1 - 2019/3/19
N2 - Anterior cruciate ligament (ACL) injuries are frequent, as >200,000 injuries occur in the United States alone each year. Owing to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated with limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. This article provides a clear operative description and associated illustrations for a validated, institutional animal care and use committee, and veterinarian approved and facile model of ACLR to serve researchers investigating ACLR.
AB - Anterior cruciate ligament (ACL) injuries are frequent, as >200,000 injuries occur in the United States alone each year. Owing to the risks for associated meniscus and cartilage damage, ACL injuries are a significant source of both orthopedic care and research. Given the extended recovery course after ACL injury, which often lasts 1-2 years, and is associated with limited participation in sports and activities of daily living for patients, there is a critical need for the evolution of new and improved methods for ACL repair. Subsequently, animal models of ACL reconstruction (ACLR) play a key role in the development and initial trialing of novel ACL interventions. This article provides a clear operative description and associated illustrations for a validated, institutional animal care and use committee, and veterinarian approved and facile model of ACLR to serve researchers investigating ACLR.
KW - animal models
KW - anterior cruciate ligament
KW - reconstruction
UR - http://www.scopus.com/inward/record.url?scp=85064535072&partnerID=8YFLogxK
U2 - 10.1089/ten.TEC.2018.0357
DO - 10.1089/ten.TEC.2018.0357
M3 - Article
C2 - 30887885
VL - 25
SP - 191
EP - 196
JO - Tissue Engineering. Part C: Methods
JF - Tissue Engineering. Part C: Methods
SN - 1937-3384
IS - 4
ER -