A three dimensional model for osteocyte-regulated remodling simulation at the tissue level

B. Rietbergen, van, M.G. Mullender, R. Huiskes

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureHoofdstukAcademicpeer review

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Samenvatting

Several hypothetical bone remodeling models have been developed to explain trabecular bone adaptation as observed in the skeleton. So far, these simulation models have been successfully used to explain the global density distribution in whole bones but were unable to simulate trabecular adaptation process at the tissue level. In the presented study, a three dimensional bone remodeling model is introduced to simulate bone remodeling at the tissue level. The model is based on an osteocyte regulated bone remodeling hypothesis. The trabecular architecture is represented by large FE models built from identical elements to allow the application of fast solution methods. It was found that the model can explain the generation of typical three dimensional architectures during morphogenesis as a result of loading. In addition, the model can explain structural changes that take place due to bone disuse.
Originele taal-2Engels
TitelComputer methods in biomechanics and biomedical engineering
Plaats van productieAmsterdam
UitgeverijGordon and Breach Science Publishers
Pagina's743-83
ISBN van geprinte versie2-919875-00-0
StatusGepubliceerd - 1996

Publicatie series

NaamComputer methods in biomechanics and biomedical engineering
Volume1

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