Uittreksel
adapting to changes in blood flow demands. Cardiac diseases can trigger
the same process leading to an abnormal type of growth. Although
several models have been published, details on this process remain still
unclear. This study offers an analysis on the driving force of cardiac
growth along with an evaluation on the final grown state. Through a
zero dimensional model of the left ventricle we evaluate cardiac growth
in response to three valve diseases, aortic and mitral regurgitation along
with aortic stenosis. We investigate how different combinations of stress
and strain based stimuli affect growth in terms of cavity volume and
wall volume. All of our simulations are able to reach a converged state
without any growth constraint. The simulated grown state corresponded
to the experimentally observed state for all valve disease cases, except
for aortic regurgitation simulated with a mix of stress and strain stimuli.
Thus we demonstrate how a simple model of left ventricular mechanics
can be used to have a first evaluation of a designed growth law.
| Taal | Engels |
|---|---|
| Titel | FIMH 2019: Functional Imaging and Modeling of the Heart |
| Redacteuren | Yves Coudière, Valéry Ozenne, Edward Vigmond, Nejib Zemzemi |
| Plaats van productie | Cham |
| Uitgeverij | Springer Nature Switzerland AG |
| Pagina's | 249-257 |
| Aantal pagina's | 9 |
| ISBN van elektronische versie | 978-3-030-21949-9 |
| ISBN van geprinte versie | 978-3-030-21948-2 |
| DOI's | |
| Status | Gepubliceerd - 2019 |
Publicatie series
| Naam | Lecture Notes in Computer Science |
|---|---|
| Uitgeverij | SpringerLink |
| Volume | 11504 |
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A simple multi-scale model to evaluate left ventricular growth laws. / Rondanina, Emanuele; Bovendeerd, Peter.
FIMH 2019: Functional Imaging and Modeling of the Heart. redactie / Yves Coudière; Valéry Ozenne; Edward Vigmond; Nejib Zemzemi. Cham : Springer Nature Switzerland AG, 2019. blz. 249-257 (Lecture Notes in Computer Science; Vol. 11504).Onderzoeksoutput: Hoofdstuk in Boek/Rapport/Congresprocedure › Hoofdstuk › Academic › peer review
TY - CHAP
T1 - A simple multi-scale model to evaluate left ventricular growth laws
AU - Rondanina,Emanuele
AU - Bovendeerd,Peter
PY - 2019
Y1 - 2019
N2 - Cardiac growth is the natural capability of the heart ofadapting to changes in blood flow demands. Cardiac diseases can triggerthe same process leading to an abnormal type of growth. Althoughseveral models have been published, details on this process remain stillunclear. This study offers an analysis on the driving force of cardiacgrowth along with an evaluation on the final grown state. Through azero dimensional model of the left ventricle we evaluate cardiac growthin response to three valve diseases, aortic and mitral regurgitation alongwith aortic stenosis. We investigate how different combinations of stressand strain based stimuli affect growth in terms of cavity volume andwall volume. All of our simulations are able to reach a converged statewithout any growth constraint. The simulated grown state correspondedto the experimentally observed state for all valve disease cases, exceptfor aortic regurgitation simulated with a mix of stress and strain stimuli.Thus we demonstrate how a simple model of left ventricular mechanicscan be used to have a first evaluation of a designed growth law.
AB - Cardiac growth is the natural capability of the heart ofadapting to changes in blood flow demands. Cardiac diseases can triggerthe same process leading to an abnormal type of growth. Althoughseveral models have been published, details on this process remain stillunclear. This study offers an analysis on the driving force of cardiacgrowth along with an evaluation on the final grown state. Through azero dimensional model of the left ventricle we evaluate cardiac growthin response to three valve diseases, aortic and mitral regurgitation alongwith aortic stenosis. We investigate how different combinations of stressand strain based stimuli affect growth in terms of cavity volume andwall volume. All of our simulations are able to reach a converged statewithout any growth constraint. The simulated grown state correspondedto the experimentally observed state for all valve disease cases, exceptfor aortic regurgitation simulated with a mix of stress and strain stimuli.Thus we demonstrate how a simple model of left ventricular mechanicscan be used to have a first evaluation of a designed growth law.
U2 - 10.1007/978-3-030-21949-9_27
DO - 10.1007/978-3-030-21949-9_27
M3 - Chapter
SN - 978-3-030-21948-2
T3 - Lecture Notes in Computer Science
SP - 249
EP - 257
BT - FIMH 2019: Functional Imaging and Modeling of the Heart
PB - Springer Nature Switzerland AG
CY - Cham
ER -