Samenvatting
We investigate a fast and sensitive optomagnetic bionanotechnology for biomarker detection. Antibody-coated superparamagnetic particles capture biomarker molecules and form clusters with a biomarker molecule sandwiched between two particles. These particle clusters can be analyzed using a rotating magnetic field which induces an oscillating light scattering cross-section, resolving sub-picomolar biomarker concentrations [Ranzoni et al, Nanoletters 2011; ACS Nano 2012].
In this paper we report a method to quantify the particle-particle distance with nanometer resolution. Simulations of the light scattering by rotating clusters show that the high-frequency components hold detailed information about the geometry of the particle clusters, including a strong dependence on the inter-particle distance. We will report the simulation results and experimental data of model cluster assays.
| Originele taal-2 | Engels |
|---|---|
| Status | Gepubliceerd - 2013 |
| Evenement | conference; Dutch meeting on molecular and cellular biophysics, 2013; 2013-09-30; 2013-10-01 - Duur: 30 sep. 2013 → 1 okt. 2013 |
Congres
| Congres | conference; Dutch meeting on molecular and cellular biophysics, 2013; 2013-09-30; 2013-10-01 |
|---|---|
| Periode | 30/09/13 → 1/10/13 |
| Ander | Dutch meeting on molecular and cellular biophysics, 2013 |