A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly

W.F. Quiros-Solano, N. Gaio, C. Silvestri, Y.B. Arik, O.M.J.A. Stassen, A.D. van der Meer, C.V.C. Bouten, A. van den Berg, R. Dekker, P.M. Sarro

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

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Samenvatting

We present a novel method to easily and reliably transfer highly porous, large area, thin microfabricated Polydimethylsiloxane (PDMS) porous membranes on Lab-on-Chip (LOC) and Organ-on-Chip (OOC) devices. The use of silicon as carrier substrate and a water-soluble sacrificial layer allows a simple and reproducible transfer of the membranes to any PDMS-based OOC and LOC device. The use of IC and MEMS compatible techniques reduces significantly the fabrication time and the need of manual handling. Our method is suitable for automatic assembling systems, such as pick-and-place, crucial to significantly increase the throughput of OOC and LOC devices assembling. Membranes with 8 μm pore size and as thin as 4 μm are successfully transferred. The viability and biocompatibility of the transfer was assessed by culturing two different cell lines on an OOC with transferred porous PDMS membranes.

Originele taal-2Engels
Titel2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
Plaats van productiePiscataway
UitgeverijInstitute of Electrical and Electronics Engineers
Pagina's318-321
Aantal pagina's4
ISBN van elektronische versie9781538647820
DOI's
StatusGepubliceerd - 24 apr 2018
Evenement31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS2018) - Belfast, Verenigd Koninkrijk
Duur: 21 jan 201825 jan 2018

Congres

Congres31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS2018)
Verkorte titelMEMS2018
LandVerenigd Koninkrijk
StadBelfast
Periode21/01/1825/01/18

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