A novel breast-cancer model of early stage invasion

Onderzoeksoutput: Bijdrage aan congresPosterAcademic

Uittreksel

The majority of breast cancer deaths are not caused by the primary tumor, but by metastasis to other organs. However, the mechanisms that underlie the first stage of metastasis, the invasion of cancer cells into surrounding tissue remain elusive, due to the complexity of the cellular, biochemical, and biophysical interactions in cancer tissue.

In this work, we propose a novel in vitro breast cancer model that focuses on dissecting the influence of the biophysical properties of the extracellular matrix (ECM) on the onset of cancer invasion. Based on microfluidic technology, it will provide us with the necessary tools to independently vary different material and cell properties, while it provides the cells with a physiologically relevant environment.
TaalEngels
StatusGepubliceerd - 2 mei 2017

Vingerafdruk

Breast Neoplasms
Neoplasms
Neoplasm Metastasis
Microfluidics
Extracellular Matrix
Technology
In Vitro Techniques

Citeer dit

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title = "A novel breast-cancer model of early stage invasion",
abstract = "The majority of breast cancer deaths are not caused by the primary tumor, but by metastasis to other organs. However, the mechanisms that underlie the first stage of metastasis, the invasion of cancer cells into surrounding tissue remain elusive, due to the complexity of the cellular, biochemical, and biophysical interactions in cancer tissue. In this work, we propose a novel in vitro breast cancer model that focuses on dissecting the influence of the biophysical properties of the extracellular matrix (ECM) on the onset of cancer invasion. Based on microfluidic technology, it will provide us with the necessary tools to independently vary different material and cell properties, while it provides the cells with a physiologically relevant environment.",
author = "J.J.F. Sleeboom and C.M. Sahlgren and {den Toonder}, J.M.J.",
year = "2017",
month = "5",
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A novel breast-cancer model of early stage invasion. / Sleeboom, J.J.F.; Sahlgren, C.M.; den Toonder, J.M.J.

2017.

Onderzoeksoutput: Bijdrage aan congresPosterAcademic

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T1 - A novel breast-cancer model of early stage invasion

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AU - Sahlgren,C.M.

AU - den Toonder,J.M.J.

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N2 - The majority of breast cancer deaths are not caused by the primary tumor, but by metastasis to other organs. However, the mechanisms that underlie the first stage of metastasis, the invasion of cancer cells into surrounding tissue remain elusive, due to the complexity of the cellular, biochemical, and biophysical interactions in cancer tissue. In this work, we propose a novel in vitro breast cancer model that focuses on dissecting the influence of the biophysical properties of the extracellular matrix (ECM) on the onset of cancer invasion. Based on microfluidic technology, it will provide us with the necessary tools to independently vary different material and cell properties, while it provides the cells with a physiologically relevant environment.

AB - The majority of breast cancer deaths are not caused by the primary tumor, but by metastasis to other organs. However, the mechanisms that underlie the first stage of metastasis, the invasion of cancer cells into surrounding tissue remain elusive, due to the complexity of the cellular, biochemical, and biophysical interactions in cancer tissue. In this work, we propose a novel in vitro breast cancer model that focuses on dissecting the influence of the biophysical properties of the extracellular matrix (ECM) on the onset of cancer invasion. Based on microfluidic technology, it will provide us with the necessary tools to independently vary different material and cell properties, while it provides the cells with a physiologically relevant environment.

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