A longitudinal feasibility study on AAA growth vs. ultrasound elastography

T.M. Vonk, V.L. Nguyen, G.W.H. Schurink, F.N. Van De Vosse, R.G.P. Lopata

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

2 Citaties (Scopus)
3 Downloads (Pure)

Uittreksel

To improve risk stratification of abdominal aortic aneurysms, ultrasound elastography could provide insight in changes in mechanical properties of the aneurysmal wall. In this feasibility study, 2-D US elastography was performed in AAA patients in a longitudinal study. Several patients with non-growing, slow growing and fast growing AAAs were imaged using 2D ultrasound. The RF-data were processed to estimate the mechanical properties, e.g., compliance (C), distensibility (D) and incremental Young's modulus (Einc). An improved RF-based tracking algorithm was used to estimate the volume changes over time, assuming rotational symmetry of the aneurysm. The estimated parameters and possible changes were compared between the three groups. Incremental moduli ranging from 1- 8 MPa were found. The distensibility ranged from 2 to 10 MPa-1. The relative increase in Einc was -10 to 100% for the patients with no growth, 25% -125% for the medium group and 75% to 700% for the patients with fast growth. Distensibility also decreased by a factor 5. The largest increase in stiffness corresponded to the largest increase in diameter. These preliminary findings imply that large changes in mechanical properties occur in the aneurysmal wall in periods of considerable growth. Automated segmentation and higher frame rates might decrease the intra-subject variability. Finally, the inclusion of more patients is required to strengthen the evidence found.

Originele taal-2Engels
Titel2014 IEEE International Ultrasonics Symposium (IUS 2014) : Chicago, Illinois, USA, 3 - 6 September 2014
Plaats van productiePiscataway
UitgeverijIEEE Computer Society
Pagina's9-12
Aantal pagina's4
ISBN van geprinte versie9781479970490
DOI's
StatusGepubliceerd - 20 okt 2014
Evenement2014 IEEE International Ultrasonics Symposium (IUS 2014) - Hilton Hotel, Chicago, Verenigde Staten van Amerika
Duur: 3 sep 20146 sep 2014
http://ewh.ieee.org/conf/ius_2014/

Congres

Congres2014 IEEE International Ultrasonics Symposium (IUS 2014)
Verkorte titelIUS 2014
LandVerenigde Staten van Amerika
StadChicago
Periode3/09/146/09/14
AnderInternational Ultrasonics Symposium
Internet adres

Vingerafdruk

mechanical properties
estimates
stratification
stiffness
modulus of elasticity
inclusions
symmetry

Citeer dit

Vonk, T. M., Nguyen, V. L., Schurink, G. W. H., Van De Vosse, F. N., & Lopata, R. G. P. (2014). A longitudinal feasibility study on AAA growth vs. ultrasound elastography. In 2014 IEEE International Ultrasonics Symposium (IUS 2014) : Chicago, Illinois, USA, 3 - 6 September 2014 (blz. 9-12). [6932001] Piscataway: IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2014.0003
Vonk, T.M. ; Nguyen, V.L. ; Schurink, G.W.H. ; Van De Vosse, F.N. ; Lopata, R.G.P. / A longitudinal feasibility study on AAA growth vs. ultrasound elastography. 2014 IEEE International Ultrasonics Symposium (IUS 2014) : Chicago, Illinois, USA, 3 - 6 September 2014 . Piscataway : IEEE Computer Society, 2014. blz. 9-12
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Vonk, TM, Nguyen, VL, Schurink, GWH, Van De Vosse, FN & Lopata, RGP 2014, A longitudinal feasibility study on AAA growth vs. ultrasound elastography. in 2014 IEEE International Ultrasonics Symposium (IUS 2014) : Chicago, Illinois, USA, 3 - 6 September 2014 ., 6932001, IEEE Computer Society, Piscataway, blz. 9-12, 2014 IEEE International Ultrasonics Symposium (IUS 2014), Chicago, Verenigde Staten van Amerika, 3/09/14. https://doi.org/10.1109/ULTSYM.2014.0003

A longitudinal feasibility study on AAA growth vs. ultrasound elastography. / Vonk, T.M.; Nguyen, V.L.; Schurink, G.W.H.; Van De Vosse, F.N.; Lopata, R.G.P.

2014 IEEE International Ultrasonics Symposium (IUS 2014) : Chicago, Illinois, USA, 3 - 6 September 2014 . Piscataway : IEEE Computer Society, 2014. blz. 9-12 6932001.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

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AU - Lopata, R.G.P.

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N2 - To improve risk stratification of abdominal aortic aneurysms, ultrasound elastography could provide insight in changes in mechanical properties of the aneurysmal wall. In this feasibility study, 2-D US elastography was performed in AAA patients in a longitudinal study. Several patients with non-growing, slow growing and fast growing AAAs were imaged using 2D ultrasound. The RF-data were processed to estimate the mechanical properties, e.g., compliance (C), distensibility (D) and incremental Young's modulus (Einc). An improved RF-based tracking algorithm was used to estimate the volume changes over time, assuming rotational symmetry of the aneurysm. The estimated parameters and possible changes were compared between the three groups. Incremental moduli ranging from 1- 8 MPa were found. The distensibility ranged from 2 to 10 MPa-1. The relative increase in Einc was -10 to 100% for the patients with no growth, 25% -125% for the medium group and 75% to 700% for the patients with fast growth. Distensibility also decreased by a factor 5. The largest increase in stiffness corresponded to the largest increase in diameter. These preliminary findings imply that large changes in mechanical properties occur in the aneurysmal wall in periods of considerable growth. Automated segmentation and higher frame rates might decrease the intra-subject variability. Finally, the inclusion of more patients is required to strengthen the evidence found.

AB - To improve risk stratification of abdominal aortic aneurysms, ultrasound elastography could provide insight in changes in mechanical properties of the aneurysmal wall. In this feasibility study, 2-D US elastography was performed in AAA patients in a longitudinal study. Several patients with non-growing, slow growing and fast growing AAAs were imaged using 2D ultrasound. The RF-data were processed to estimate the mechanical properties, e.g., compliance (C), distensibility (D) and incremental Young's modulus (Einc). An improved RF-based tracking algorithm was used to estimate the volume changes over time, assuming rotational symmetry of the aneurysm. The estimated parameters and possible changes were compared between the three groups. Incremental moduli ranging from 1- 8 MPa were found. The distensibility ranged from 2 to 10 MPa-1. The relative increase in Einc was -10 to 100% for the patients with no growth, 25% -125% for the medium group and 75% to 700% for the patients with fast growth. Distensibility also decreased by a factor 5. The largest increase in stiffness corresponded to the largest increase in diameter. These preliminary findings imply that large changes in mechanical properties occur in the aneurysmal wall in periods of considerable growth. Automated segmentation and higher frame rates might decrease the intra-subject variability. Finally, the inclusion of more patients is required to strengthen the evidence found.

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Vonk TM, Nguyen VL, Schurink GWH, Van De Vosse FN, Lopata RGP. A longitudinal feasibility study on AAA growth vs. ultrasound elastography. In 2014 IEEE International Ultrasonics Symposium (IUS 2014) : Chicago, Illinois, USA, 3 - 6 September 2014 . Piscataway: IEEE Computer Society. 2014. blz. 9-12. 6932001 https://doi.org/10.1109/ULTSYM.2014.0003