A high-fidelity and micro-anatomically accurate 3D finite element model for simulations of functional mitral valve

Chung Hao Lee, Pim J.A. Oomen, Jean Pierre Rabbah, Ajit Yoganathan, Robert C. Gorman, Joseph H. Gorman, Rouzbeh Amini, Michael S. Sacks

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureHoofdstukAcademicpeer review

21 Citaten (Scopus)
1 Downloads (Pure)

Samenvatting

Promising mitral valve (MV) repair concepts include leaflet augmentation and saddle shaped annuloplasty, and recent long-term studies have indicated that excessive tissue stress and the resulting strain-induced tissue failure are important etiologic factors leading to the recurrence of significant MR after repair. In the present work, we are aiming at developing a high-fidelity computational framework, incorporating detailed collagen fiber architecture, accurate constitutive models for soft valve tissues, and micro-anatomically accurate valvular geometry, for simulations of functional mitral valves which allows us to investigate the organ-level mechanical responses due to physiological loadings. This computational tools also provides a means, with some extension in the future, to help the understanding of the connection between the repair-induced altered stresses/strains and valve functions, and ultimately to aid in the optimal design of MV repair procedure with better performance and durability.

Originele taal-2Engels
TitelFunctional Imaging and Modeling of the Heart - 7th International Conference, FIMH 2013, Proceedings
RedacteurenS. Ourselin, D. Rueckert, N. Smith
Plaats van productieBerlin
UitgeverijSpringer
Pagina's416-424
Aantal pagina's9
ISBN van geprinte versie978-3-642-38899-6
DOI's
StatusGepubliceerd - 11 jul 2013
Evenement7th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2013 - London, Verenigd Koninkrijk
Duur: 20 jun 201322 jun 2013
http://fimh2013.cs.ucl.ac.uk/

Publicatie series

NaamLecture Notes in Computer Science
Volume7945
ISSN van geprinte versie0302-9743
ISSN van elektronische versie1611-3349

Congres

Congres7th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2013
Verkorte titelFIMH 2013
LandVerenigd Koninkrijk
StadLondon
Periode20/06/1322/06/13
Ander7th International Conference on Functional Imaging and Modeling of the Heart
Internet adres

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  • Citeer dit

    Lee, C. H., Oomen, P. J. A., Rabbah, J. P., Yoganathan, A., Gorman, R. C., Gorman, J. H., Amini, R., & Sacks, M. S. (2013). A high-fidelity and micro-anatomically accurate 3D finite element model for simulations of functional mitral valve. In S. Ourselin, D. Rueckert, & N. Smith (editors), Functional Imaging and Modeling of the Heart - 7th International Conference, FIMH 2013, Proceedings (blz. 416-424). (Lecture Notes in Computer Science; Vol. 7945). Springer. https://doi.org/10.1007%2F978-3-642-38899-6_49, https://doi.org/10.1007/978-3-642-38899-6_49, https://doi.org/10.1007/978-3-642-38899-6_49