A DEP-based lab-on-a-chip system for the detection of multidrug resistance in K562 leukemia cells

Y. Demircan Yalçın, G. Özkayar, E. Özgür, U. Gündüz, H. Külah

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

1 Citaat (Scopus)

Samenvatting

This study presents a DEP-based lab-on-a-chip (LOC) system for label-free detection of multidrug resistant (MDR) K562 leukemia cells in a cell mixture, consisting of red blood cells (RBCs) and MDR-K562 cells, for the first time in the literature. The system consists of 2 consecutive DEP units, one for the depletion of RBCs and the other for capturing of MDR-K562 cells. RBCs are depleted by 60% in the first unit. In the second unit, MDR-K562 cell detection is performed with 100% selectivity at a flow rate of 10 μl/min and at 20 Vpp in a cell mixture, containing less than 25% MDR-K562 cells.

Originele taal-2Engels
Titel2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016
RedacteurenMark G. Allen, Tina Lamers
UitgeverijTransducer Research Foundation
Pagina's316-319
Aantal pagina's4
ISBN van elektronische versie9781940470023
DOI's
StatusGepubliceerd - 1 jan 2016
Extern gepubliceerdJa
Evenement2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016 - Hilton Head, Verenigde Staten van Amerika
Duur: 5 jun 20169 jun 2016

Congres

Congres2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016
Land/RegioVerenigde Staten van Amerika
StadHilton Head
Periode5/06/169/06/16

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