A continuum model for platelet plug formation and growth under flow

F. Storti, F.N. van de Vosse, T.H.S. van Kempen

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

27 Citaten (Scopus)

Samenvatting

When the wall of a blood vessel is damaged, the immediate response of the body to prevent blood loss is the creation of a platelet plug. The process is both chemical (platelets are chemically activated to adhere to the injured wall) and mechanical (platelets are convected by blood flow, which interacts with the forming plug). A continuum model for platelet plug formation and growth is presented in this work, which allows to study the interaction between platelet plug morphology
and local haemodynamics. The framework consists of two parts: a biochemical model [5] and a platelet plug growth model. Results for different cases are shown, together with a comparison between the sole biochemical model and the complete model which includes plug growth. The model opens the way to the development of continuum models for full blod clot formation and growth in physiologically relevant configurations.
Originele taal-2Engels
Titel3rd International Conference on Computational and Mathematical Biomedical Engineering,
RedacteurenP. Nithiarasu, R. Löhner, K.M. Liew
UitgeverijCMBE
Pagina's85-88
ISBN van geprinte versie978-0-9562914-2-4
StatusGepubliceerd - 2013
Evenement3rd International Conference on Computational & Mathematical Biomedical Engineering (CMBE13) - City University of Hong Kong, Hong Kong, China
Duur: 16 dec 201318 dec 2013
http://www.compbiomed.net/2013/

Congres

Congres3rd International Conference on Computational & Mathematical Biomedical Engineering (CMBE13)
Verkorte titelCMBE13
Land/RegioChina
StadHong Kong
Periode16/12/1318/12/13
AnderInternational Conference on Computational and Mathematical Biomedical Engineering
Internet adres

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