A continuum model for platelet plug formation and growth under flow

F. Storti, F.N. van de Vosse, T.H.S. van Kempen

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

21 Citaties (Scopus)

Uittreksel

When the wall of a blood vessel is damaged, the immediate response of the body to prevent blood loss is the creation of a platelet plug. The process is both chemical (platelets are chemically activated to adhere to the injured wall) and mechanical (platelets are convected by blood flow, which interacts with the forming plug). A continuum model for platelet plug formation and growth is presented in this work, which allows to study the interaction between platelet plug morphology
and local haemodynamics. The framework consists of two parts: a biochemical model [5] and a platelet plug growth model. Results for different cases are shown, together with a comparison between the sole biochemical model and the complete model which includes plug growth. The model opens the way to the development of continuum models for full blod clot formation and growth in physiologically relevant configurations.
Originele taal-2Engels
Titel3rd International Conference on Computational and Mathematical Biomedical Engineering,
RedacteurenP. Nithiarasu, R. Löhner, K.M. Liew
UitgeverijCMBE
Pagina's85-88
ISBN van geprinte versie978-0-9562914-2-4
StatusGepubliceerd - 2013
Evenement3rd International Conference on Computational & Mathematical Biomedical Engineering (CMBE13) - City University of Hong Kong, Hong Kong, China
Duur: 16 dec 201318 dec 2013
http://www.compbiomed.net/2013/

Congres

Congres3rd International Conference on Computational & Mathematical Biomedical Engineering (CMBE13)
Verkorte titelCMBE13
LandChina
StadHong Kong
Periode16/12/1318/12/13
AnderInternational Conference on Computational and Mathematical Biomedical Engineering
Internet adres

Vingerafdruk

Interaction
Growth model

Citeer dit

Storti, F., van de Vosse, F. N., & van Kempen, T. H. S. (2013). A continuum model for platelet plug formation and growth under flow. In P. Nithiarasu, R. Löhner, & K. M. Liew (editors), 3rd International Conference on Computational and Mathematical Biomedical Engineering, (blz. 85-88). CMBE.
Storti, F. ; van de Vosse, F.N. ; van Kempen, T.H.S. / A continuum model for platelet plug formation and growth under flow. 3rd International Conference on Computational and Mathematical Biomedical Engineering,. redacteur / P. Nithiarasu ; R. Löhner ; K.M. Liew. CMBE, 2013. blz. 85-88
@inproceedings{9f4b178bd78942f284e47bc817979c64,
title = "A continuum model for platelet plug formation and growth under flow",
abstract = "When the wall of a blood vessel is damaged, the immediate response of the body to prevent blood loss is the creation of a platelet plug. The process is both chemical (platelets are chemically activated to adhere to the injured wall) and mechanical (platelets are convected by blood flow, which interacts with the forming plug). A continuum model for platelet plug formation and growth is presented in this work, which allows to study the interaction between platelet plug morphologyand local haemodynamics. The framework consists of two parts: a biochemical model [5] and a platelet plug growth model. Results for different cases are shown, together with a comparison between the sole biochemical model and the complete model which includes plug growth. The model opens the way to the development of continuum models for full blod clot formation and growth in physiologically relevant configurations.",
author = "F. Storti and {van de Vosse}, F.N. and {van Kempen}, T.H.S.",
year = "2013",
language = "English",
isbn = "978-0-9562914-2-4",
pages = "85--88",
editor = "P. Nithiarasu and R. L{\"o}hner and K.M. Liew",
booktitle = "3rd International Conference on Computational and Mathematical Biomedical Engineering,",
publisher = "CMBE",

}

Storti, F, van de Vosse, FN & van Kempen, THS 2013, A continuum model for platelet plug formation and growth under flow. in P Nithiarasu, R Löhner & KM Liew (redactie), 3rd International Conference on Computational and Mathematical Biomedical Engineering,. CMBE, blz. 85-88, 3rd International Conference on Computational & Mathematical Biomedical Engineering (CMBE13), Hong Kong, China, 16/12/13.

A continuum model for platelet plug formation and growth under flow. / Storti, F.; van de Vosse, F.N.; van Kempen, T.H.S.

3rd International Conference on Computational and Mathematical Biomedical Engineering,. redactie / P. Nithiarasu; R. Löhner; K.M. Liew. CMBE, 2013. blz. 85-88.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

TY - GEN

T1 - A continuum model for platelet plug formation and growth under flow

AU - Storti, F.

AU - van de Vosse, F.N.

AU - van Kempen, T.H.S.

PY - 2013

Y1 - 2013

N2 - When the wall of a blood vessel is damaged, the immediate response of the body to prevent blood loss is the creation of a platelet plug. The process is both chemical (platelets are chemically activated to adhere to the injured wall) and mechanical (platelets are convected by blood flow, which interacts with the forming plug). A continuum model for platelet plug formation and growth is presented in this work, which allows to study the interaction between platelet plug morphologyand local haemodynamics. The framework consists of two parts: a biochemical model [5] and a platelet plug growth model. Results for different cases are shown, together with a comparison between the sole biochemical model and the complete model which includes plug growth. The model opens the way to the development of continuum models for full blod clot formation and growth in physiologically relevant configurations.

AB - When the wall of a blood vessel is damaged, the immediate response of the body to prevent blood loss is the creation of a platelet plug. The process is both chemical (platelets are chemically activated to adhere to the injured wall) and mechanical (platelets are convected by blood flow, which interacts with the forming plug). A continuum model for platelet plug formation and growth is presented in this work, which allows to study the interaction between platelet plug morphologyand local haemodynamics. The framework consists of two parts: a biochemical model [5] and a platelet plug growth model. Results for different cases are shown, together with a comparison between the sole biochemical model and the complete model which includes plug growth. The model opens the way to the development of continuum models for full blod clot formation and growth in physiologically relevant configurations.

M3 - Conference contribution

SN - 978-0-9562914-2-4

SP - 85

EP - 88

BT - 3rd International Conference on Computational and Mathematical Biomedical Engineering,

A2 - Nithiarasu, P.

A2 - Löhner, R.

A2 - Liew, K.M.

PB - CMBE

ER -

Storti F, van de Vosse FN, van Kempen THS. A continuum model for platelet plug formation and growth under flow. In Nithiarasu P, Löhner R, Liew KM, redacteurs, 3rd International Conference on Computational and Mathematical Biomedical Engineering,. CMBE. 2013. blz. 85-88