A biohybrid synapse with neurotransmitter-mediated plasticity

Scott T. Keene, Claudia Lubrano, Setareh Kazemzadeh, Armantas Melianas, Yaakov Tuchman, Giuseppina Polino, Paola Scognamiglio, Lucio Cinà, Alberto Salleo (Corresponding author), Yoeri B. van de Burgt (Corresponding author), Francesca Santoro (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

220 Citaten (Scopus)
462 Downloads (Pure)


Brain-inspired computing paradigms have led to substantial advances in the automation of visual and linguistic tasks by emulating the distributed information processing of biological systems1. The similarity between artificial neural networks (ANNs) and biological systems has inspired ANN implementation in biomedical interfaces including prosthetics2 and brain-machine interfaces3. While promising, these implementations rely on software to run ANN algorithms. Ultimately, it is desirable to build hardware ANNs4,5 that can both directly interface with living tissue and adapt based on biofeedback6,7. The first essential step towards biologically integrated neuromorphic systems is to achieve synaptic conditioning based on biochemical signalling activity. Here, we directly couple an organic neuromorphic device with dopaminergic cells to constitute a biohybrid synapse with neurotransmitter-mediated synaptic plasticity. By mimicking the dopamine recycling machinery of the synaptic cleft, we demonstrate both long-term conditioning and recovery of the synaptic weight, paving the way towards combining artificial neuromorphic systems with biological neural networks.
Originele taal-2Engels
Pagina's (van-tot)969-973
Aantal pagina's5
TijdschriftNature Materials
Nummer van het tijdschrift9
StatusGepubliceerd - 1 sep. 2020


National Science Foundation(NSF)
Semiconductor Research Corporation1739795
Stanford University
Horizon 2020 Framework Programme
H2020 European Research Council802615
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungECCS‐1542152
Knut och Alice Wallenbergs StiftelseKAW 2016.0494


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