3-D quantitative dynamic contrast ultrasound for prostate cancer localization

S.G. Schalk, J. Huang, J. Li, L. Demi, H. Wijkstra, P. Huang, M. Mischi

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

11 Citaten (Scopus)
79 Downloads (Pure)


To investigate quantitative 3-D dynamic contrast-enhanced ultrasound (DCE-US) and, in particular 3-D contrast-ultrasound dispersion imaging (CUDI), for prostate cancer detection and localization, 43 patients referred for 10-12-core systematic biopsy underwent 3-D DCE-US. For each 3-D DCE-US recording, parametric maps of CUDI-based and perfusion-based parameters were computed. The parametric maps were divided in regions, each corresponding to a biopsy core. The obtained parameters were validated per biopsy location and after combining two or more adjacent regions. For CUDI by correlation (r) and for the wash-in time (WIT), a significant difference in parameter values between benign and malignant biopsy cores was found (p < 0.001). In a per-prostate analysis, sensitivity and specificity were 94% and 50% for r, and 53% and 81% for WIT. Based on these results, it can be concluded that quantitative 3-D DCE-US could aid in localizing prostate cancer. Therefore, we recommend follow-up studies to investigate its value for targeting biopsies.

Originele taal-2Engels
Pagina's (van-tot)807-814
Aantal pagina's8
TijdschriftUltrasound in Medicine and Biology
Nummer van het tijdschrift4
Vroegere onlinedatum22 jan. 2018
StatusGepubliceerd - apr. 2018


Duik in de onderzoeksthema's van '3-D quantitative dynamic contrast ultrasound for prostate cancer localization'. Samen vormen ze een unieke vingerafdruk.

Citeer dit