3-D oxygen gradient chip for cancer cell migration research

Pan Zuo; Jelle J.F. Sleeboom; Jaap M.J. den Toonder

3-D oxygen gradient chip for cancer cell migration research

Pan Zuo, Jelle J.F. Sleeboom, Jaap M.J. den Toonder

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/Congresprocedure › Conferentiebijdrage › Academic › peer review

Samenvatting

Metastasis, the major cause of cancer related deaths, is a multi-step procedure, influenced by many factors and cues present in the tumor microenvironment. One important but not thoroughly studied factor is hypoxia. In this study, we introduce the design, fabrication and validation of a PDMS chip to study the effect of hypoxia on the migration of cancer cells in 3D. The chip contains a cell culture chamber in which a linear and stable oxygen gradient can be established by an oxygen leaching fluid flowing through a neighboring channel, and enables to observe the migration of cancer cells in 3D.

Originele taal-2	Engels
Titel	MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Uitgeverij	Royal Society of Chemistry
Pagina's	514-515
Aantal pagina's	2
ISBN van elektronische versie	9781733419048
Status	Gepubliceerd - 2022
Evenement	26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 - Hybrid, Hangzhou, China Duur: 23 okt. 2022 → 27 okt. 2022

Congres

Congres	26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022
Land/Regio	China
Stad	Hybrid, Hangzhou
Periode	23/10/22 → 27/10/22

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@inproceedings{9dfdb672179540f7b1983208802fd38c,

title = "3-D oxygen gradient chip for cancer cell migration research",

abstract = "Metastasis, the major cause of cancer related deaths, is a multi-step procedure, influenced by many factors and cues present in the tumor microenvironment. One important but not thoroughly studied factor is hypoxia. In this study, we introduce the design, fabrication and validation of a PDMS chip to study the effect of hypoxia on the migration of cancer cells in 3D. The chip contains a cell culture chamber in which a linear and stable oxygen gradient can be established by an oxygen leaching fluid flowing through a neighboring channel, and enables to observe the migration of cancer cells in 3D.",

keywords = "3D Culturing, Hypoxia, Metastasis, Microfluidic Chip, Oxygen Gradient",

author = "Pan Zuo and Sleeboom, {Jelle J.F.} and {den Toonder}, {Jaap M.J.}",

year = "2022",

language = "English",

pages = "514--515",

booktitle = "MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "Royal Society of Chemistry",

address = "United Kingdom",

note = "26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 ; Conference date: 23-10-2022 Through 27-10-2022",

}

Zuo, P , Sleeboom, JJF & den Toonder, JMJ 2022, 3-D oxygen gradient chip for cancer cell migration research. in MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Royal Society of Chemistry, blz. 514-515, 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022, Hybrid, Hangzhou, China, 23/10/22.

3-D oxygen gradient chip for cancer cell migration research. / Zuo, Pan ; Sleeboom, Jelle J.F.; den Toonder, Jaap M.J.
MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Royal Society of Chemistry, 2022. blz. 514-515.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/Congresprocedure › Conferentiebijdrage › Academic › peer review

TY - GEN

T1 - 3-D oxygen gradient chip for cancer cell migration research

AU - Zuo, Pan

AU - Sleeboom, Jelle J.F.

AU - den Toonder, Jaap M.J.

PY - 2022

Y1 - 2022

N2 - Metastasis, the major cause of cancer related deaths, is a multi-step procedure, influenced by many factors and cues present in the tumor microenvironment. One important but not thoroughly studied factor is hypoxia. In this study, we introduce the design, fabrication and validation of a PDMS chip to study the effect of hypoxia on the migration of cancer cells in 3D. The chip contains a cell culture chamber in which a linear and stable oxygen gradient can be established by an oxygen leaching fluid flowing through a neighboring channel, and enables to observe the migration of cancer cells in 3D.

AB - Metastasis, the major cause of cancer related deaths, is a multi-step procedure, influenced by many factors and cues present in the tumor microenvironment. One important but not thoroughly studied factor is hypoxia. In this study, we introduce the design, fabrication and validation of a PDMS chip to study the effect of hypoxia on the migration of cancer cells in 3D. The chip contains a cell culture chamber in which a linear and stable oxygen gradient can be established by an oxygen leaching fluid flowing through a neighboring channel, and enables to observe the migration of cancer cells in 3D.

KW - 3D Culturing

KW - Hypoxia

KW - Metastasis

KW - Microfluidic Chip

KW - Oxygen Gradient

UR - http://www.scopus.com/inward/record.url?scp=85175714720&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:85175714720

SP - 514

EP - 515

BT - MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Royal Society of Chemistry

T2 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022

Y2 - 23 October 2022 through 27 October 2022

ER -

3-D oxygen gradient chip for cancer cell migration research

Samenvatting

Congres

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