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Persoonlijk profiel

Quote

"In scientific research, it is important to never reach a steady state."

Research profile

Research in the Noël group encompasses the development of new catalytic strategies and technologies for chemical synthesis. The catalytic targets are chosen in such a way that continuous-flow microreactors and chemical engineering principles can make a substantial impact. By building bridges between chemical engineering and organic synthetic chemistry, long-standing problems in synthetic chemistry can be overcome. These includes scalability, gas-liquid reactions, photochemistry, electrochemistry and the generation and use of hazardous reagents. The unique approach at the interface of organic synthetic chemistry and chemical engineering enables the Noël group to rapidly recognize those synthetic problems that would benefit from microreactor technology.

The group strives to develop new technological tools that are of interest to the pharmaceutical industry and can overcome challenges in a variety of specialty applications, e.g. organic synthesis, chemical biology, material science, etc. The ambition is to develop new catalytic strategies for chemical synthesis that engage novel reactivity concepts which facilitate the rapid generation of biologically active molecules. In the long run this would lead to an automated and chemo-catalytic equivalent to Nature’s biosynthetic machinery that is able to build essentially any molecule on demand.

Academic background

Timothy Noël obtained his MSc in Industrial Chemical Engineering from KaHo Sint Lieven (Ghent, Belgium) in 2004. In 2009, he received his PhD at the Laboratory for Organic and Bioorganic Synthesis at Ghent University under supervision of Prof. Johan Van der Eycken with his thesis 'Synthesis and application of chiral dienes and chiral imidates for asymmetric transition metal catalysis'. He then moved to the Massachusetts Institute of Technology as a Fulbright Postdoctoral Fellow with Prof. Stephen L. Buchwald (MIT-Novartis Center for Continuous Manufacturing) where he worked on the development of new continuous-flow methods for cross-coupling chemistry. In 2012 he was appointed assistant professor at Eindhoven University of Technology (TU/e) and in 2017 associate professor with the research group Micro Flow Chemistry and Process Technology.

Affiliated with

  • Flow Chemistry Society
  • Ghent University

Partners in (semi-)industry

  • AbbVie
  • InnoStudio Scientific Advisory Board member

Vingerafdruk Duik in de onderzoeksthema's waar Timothy Noël actief is. Deze onderwerplabels komen voort uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.

  • 2 Vergelijkbare profielen
Photochemical reactions Chemische stoffen
Catalysis Chemische stoffen
Catalysts Chemische stoffen
Solar concentrators Chemische stoffen
Photocatalysts Chemische stoffen
Packed beds Chemische stoffen
Sulfhydryl Compounds Chemische stoffen
Disulfides Chemische stoffen

Netwerk Recente externe samenwerking op landenniveau. Duik in de details door op de stippen te klikken.

Onderzoeksoutput 2011 2020

44 Citaties (Scopus)
203 Downloads (Pure)

A leaf-inspired luminescent solar concentrator for energy-efficient continuous-flow photochemistry

Cambié, D., Zhao, F., Hessel, V., Debije, M. G. & Noël, T., 19 jan 2017, In : Angewandte Chemie - International Edition. 56, 4, blz. 1050-1054 5 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Solar concentrators
Photochemical reactions
Polydimethylsiloxane
Microchannels
Fluorescent Dyes
30 Citaties (Scopus)
87 Downloads (Pure)

A modular flow design for the meta-selective C-H arylation of anilines

Gemoets, H. P. L., Laudadio, G., Verstraete, K., Hessel, V. & Noël, T., 12 jun 2017, In : Angewandte Chemie - International Edition. 56, 25, blz. 7161-7165 5 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Aniline Compounds
Aniline
Copper
Column chromatography
Salts
29 Citaties (Scopus)
119 Downloads (Pure)

An environmentally benign and selective electrochemical oxidation of sulfides and thiols in a continuous-flow microreactor

Laudadio, G., Straathof, N. J. W., Lanting, M. D., Knoops, B., Hessel, V. & Noël, T., 7 aug 2017, In : Green Chemistry. 19, blz. 4061-4066 6 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Electrochemical oxidation
thiol
Sulfides
Sulfhydryl Compounds
sulfide

CFD analysis of a luminescent solar concentrator-based photomicroreactor (LSC-PM) with feedforward control applied to the synthesis of chemicals under fluctuating light intensity

de Oliveira, G. X., Lira, J. O. B., Cambié, D., Noël, T., Riella, H. G., Padoin, N. & Soares, C., 1 jan 2020, In : Chemical Engineering Research and Design. 153, blz. 626-634 9 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Solar concentrators
Feedforward control
Dynamic analysis
Computational fluid dynamics
Dynamic models

Screening of functional solvent system for automatic aldehyde and ketone separation in aldol reaction: a combined COSMO-RS and experimental approach

Zhang, C., Song, Z., Jin, C., Nijhuis, J., Zhou, T., Noël, T., Gröger, H., Sundmacher, K., van Hest, J. & Hessel, V., 1 apr 2020, In : Chemical Engineering Journal. 385, 10 blz., 123399.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
ketone
aldehyde
Ketones
Aldehydes
Screening

Prijzen

NWO Veni Award : Breakthrough in drug development

T. Noël (Ontvanger), 2012

Prijs: NWOVeniWetenschappelijk

Fluorine
Pharmaceutical Preparations
Research Personnel

NWO Vidi Award : Home run for photochemistry!

T. Noël (Ontvanger), 2014

Prijs: NWOVidiWetenschappelijk

Photochemical reactions
Chemical reactions
Catalysts

Pers/media

This Synthetic Leaf Turns Sunlight Into Drugs

Timothy Noël

11/09/1912/09/19

3 items van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Can an artificial leaf make the pharmaceutical industry greener?

Timothy Noël

11/09/1912/09/19

2 items van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Researchers produce medicine from sunlight from ‘artificial leaf’

Timothy Noël

9/09/19

1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Scriptie

A broadly applicable red dye doped Luminescent Solar Concentrator photo microreactor

Auteur: Dobbelaar, J., mei 2017

Begeleider: Cambié, D. (Afstudeerdocent 1), Noël, T. (Afstudeerdocent 2), Hessel, V. (Afstudeerdocent 2) & Debije, M. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Accurate measurements of the photon flux in multiphase reactor systems by actinometry

Auteur: Verijke, R., 30 apr 2016

Begeleider: Noël, T. (Afstudeerdocent 1), Su, Y. (Afstudeerdocent 2), Hessel, V. (Afstudeerdocent 2) & Roghair, I. (Externe coach)

Scriptie/masterproef: Master

Bestand

A comparison between classical cross-coupling and C-H activation via experiments, cost analysis and green metrics

Auteur: Schouten, A., 31 aug 2016

Begeleider: Gemoets, H. (Afstudeerdocent 1), Noël, T. (Afstudeerdocent 2), Hessel, V. (Afstudeerdocent 2) & Peters, E. (Externe coach)

Scriptie/masterproef: Master

A convenient internal numbering-up strategy for the scale up of gas-liquid photoredox catalysis

Auteur: Kuijpers, K. P., 31 jan 2016

Begeleider: Su, Y. (Afstudeerdocent 1), Noël, T. (Afstudeerdocent 2), Hessel, V. (Afstudeerdocent 2) & Padding, J. (Externe coach)

Scriptie/masterproef: Master

Bestand

Arylation of cysteine residues via photoredox catalysis in batch and flow

Auteur: van den Bosch, M., 31 aug 2017

Begeleider: Noël, T. (Afstudeerdocent 1)

Scriptie/masterproef: Master

Bestand