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Persoonlijk profiel

Quote

"Computational modeling has critically advanced our understanding of growth and remodeling of engineered cardiovascular tissues."

Research profile

Sandra Loerakker is an associate professor at the TU/e department of Biomedical Engineering (research group Soft Tissue Engineering and Mechanobiology). Her expertise is in modeling the mechanobiology of native and engineered tissues using integrated computational and experimental methods. The ultimate goal of her research is to obtain a fundamental understanding of the biological mechanisms responsible for soft tissue development, homeostasis, and disease, and to translate those findings into novel therapies in the field of regenerative medicine. She primarily focuses on understanding how mechanical factors drive soft tissue growth and remodeling at different spatial and temporal scales.

Examples of her research include the computational analysis of growth and remodeling of native cardiovascular tissues; the analysis and prediction of in vivo remodeling of engineered cardiovascular tissues; systematic investigations of the potential impact of implant design on the remodeling of engineered tissues; the establishment of in vitro platforms to experimentally analyze soft tissue growth and remodeling; and the development of computational models to understand and predict the interplay between mechanics and cell-cell signaling in growth and remodeling.

Academic background

Sandra Loerakker was trained in Biomedical Engineering at Eindhoven University of Technology (TU/e) where she obtained both her BSc and MSc degrees cum laude. Her MSc project concerned the development of a computational model to analyze flow fields in a failing heart supported by a ventricular assist device. In 2007, she started her PhD research on the etiology and early detection of deep pressure ulcers in skeletal muscle, using a combination of computational and experimental methods. She performed part of this research at Northwestern University (USA) and in collaboration with the University of Alberta (Canada). After defending her PhD thesis at TU/e in 2011, she continued as a postdoctoral researcher in heart valve biomechanics and mechanobiology. In 2015, she was appointed as assistant professor in Modeling in Mechanobiology at the TU/e department of Biomedical Engineering, focusing on understanding the mechanobiology of native and engineered tissues using integrated computational and experimental methods. From May 2016 – April 2017, supported by a Marie Curie Individual Fellowship, she was a visiting assistant professor at Stanford University (USA). She received an ERC Starting Grant in 2018 to explore the interplay between mechanics and cell-cell signaling in the context of cardiovascular regeneration. In 2019, she was promoted to associate professor.

Vingerafdruk Duik in de onderzoeksthema's waar Sandra Loerakker actief is. Deze onderwerplabels komen voort uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.

  • 26 Vergelijkbare profielen
Tissue Engineering en materiaalwetenschappen
Heart Valves Medicijnen en Levenswetenschappen
Collagen Engineering en materiaalwetenschappen
Muscle Engineering en materiaalwetenschappen
Pressure Ulcer Medicijnen en Levenswetenschappen
Stress Fibers Medicijnen en Levenswetenschappen
Tissue engineering Engineering en materiaalwetenschappen
Wounds and Injuries Medicijnen en Levenswetenschappen

Netwerk Recente externe samenwerking op landenniveau. Duik in de details door op de stippen te klikken.

Onderzoeksoutput 2007 2020

6 Downloads (Pure)
Open Access
Bestand
Tissue Engineering
Tissue engineering
Scaffolds
Tissue
Gastrin-Secreting Cells
11 Downloads (Pure)

A computational model to predict cell traction-mediated prestretch in the mitral valve

van Kelle, M. A. J., Rausch, M. K., Kuhl, E. & Loerakker, S., 18 nov 2019, In : Computer Methods in Biomechanics and Biomedical Engineering. 22, 15, blz. 1174-1185 12 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Tissue
Actins
Structural properties
Anisotropy
Fibers
4 Downloads (Pure)

Biomechanics and modeling of tissue-engineered heart valves

Ristori, T., van Kelle, A. J. M., Baaijens, F. & Loerakker, S., 9 apr 2019, Advances in heart valve biomechanics: valvular physiology, mechanobiology, and bioengineering. Sacks, M. & Liao, J. (redactie). Cham: Springer, blz. 413-446 34 blz.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureHoofdstukAcademic

Biomechanics
Tissue engineering
Tissue
Collagen
Heart valve prostheses
1 Citaat (Scopus)
30 Downloads (Pure)

Increased cell traction-induced prestress in dynamically cultured microtissues

van Kelle, M. A. J., Khalil, N., Foolen, J., Loerakker, S. & Bouten, C. V. C., 12 mrt 2019, In : Frontiers in Bioengineering and Biotechnology. 7, 11 blz., 41.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
8 Downloads (Pure)

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress

van Engeland, N. C. A., Suarez Rodriguez, F., Rivero-Müller, A., Ristori, T., Duran, C. L., Stassen, O. M. J. A., Antfolk, D., Driessen, R. C. H., Ruohonen, S., Ruohonen, S. T., Nuutinen, S., Savontaus, E., Loerakker, S., Bayless, K. J., Sjöqvist, M., Bouten, C. V. C., Eriksson, J. E. & Sahlgren, C. M., 27 aug 2019, In : Scientific Reports. 9, 1, 14 blz., 12415.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Vimentin
Hemodynamics
Vascular Smooth Muscle
Transcriptional Activation
Smooth Muscle Myocytes

Prijzen

Predicting cardiovascular regeneration

S. Loerakker (Ontvanger), 2018

Prijs: ERCStartingWetenschappelijk

Regeneration
Tissue Engineering
Heart Valves
Biocompatible Materials
Population Groups

Cursussen

Numerieke analyse van continua

1/09/13 → …

Cursus

Project Biomechanics

1/09/14 → …

Cursus

Pers/media

-Trinity student wins two significant Biomedical Engineering awards

Carlijn V.C. Bouten & Sandra Loerakker

8/10/18

1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Trinity student wins two significant Biomedical Engineering awards

Carlijn V.C. Bouten & Sandra Loerakker

6/10/18

1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Scriptie

A constitutive material model to describe the mechanical behavior of human skin in shear, tensile and indentation tests

Auteur: Rooijakkers, T., 31 aug 2017

Begeleider: Oomens, C. (Afstudeerdocent 1), Loerakker, S. (Afstudeerdocent 2), Lopata, R. (Afstudeerdocent 2) & Soetens, J. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Biochemical muscle damage markers for early detection of deep pressure ulcers: a pilot study and a kinetics model

Auteur: Huisman, E., 28 feb 2010

Begeleider: Baaijens, F. (Afstudeerdocent 1), Oomens, C. (Afstudeerdocent 2), Bouten, C. (Afstudeerdocent 2), Loerakker, S. (Afstudeerdocent 2), Seelen, H. (Afstudeerdocent 2) & Glatz, J. F. (Externe persoon) (Afstudeerdocent 2)

Scriptie/masterproef: Master

Causes and consequences of collagen architecture remodeling in human native heart valves: temporal changes from the fetal to the adult heart valve

Auteur: Oomen, P., 31 mrt 2014

Begeleider: Baaijens, F. (Afstudeerdocent 1), Bouten, C. (Afstudeerdocent 2), Loerakker, S. (Afstudeerdocent 2), Bovendeerd, P. (Afstudeerdocent 2) & van Donkelaar, C. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Development of a finite element spine model to simulate different scoliosis treatment scenarios

Auteur: van der Meer, R., 30 apr 2016

Begeleider: van Rietbergen, B. (Afstudeerdocent 1), Ito, K. (Afstudeerdocent 2), Arts, J. (Afstudeerdocent 2), Roth, A. (Afstudeerdocent 2) & Loerakker, S. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Effects of mechanical constraints on cell-generated stress and collagen remodeling in statically cultured tissues

Auteur: van Kelle, A., 30 apr 2014

Begeleider: Bouten, C. (Afstudeerdocent 1), Baaijens, F. (Afstudeerdocent 2), van Rietbergen, B. (Afstudeerdocent 2), Loerakker, S. (Afstudeerdocent 2) & van Loosdregt, I. (Afstudeerdocent 2)

Scriptie/masterproef: Master