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Persoonlijk profiel

Quote

Bone cells are the engineers of bone. They build new bone or break it down in reaction to their environment, keeping the bone healthy or causing a disease. But how exactly do they interact with each other?

Research profile

Sandra Hofmann is an Associate Professor at the Orthopaedic Biomechanics research group. Her current research focuses on tissue engineering of skeletal tissues, in particular bone. A special focus lies on visualization and understanding of how cells react to environmental and influential parameters (chemical, mechanical, other cells) in tissue-engineered in vitro models of bone tissue. 

Bone diseases are multifaceted and can have a highly deleterious impact on life and society. Moreover, ageing of the population imposes us with increasing numbers of persons suffering from skeletal issues. It is well known that a varying environment (cellular, chemical, mechanical environment) can have substantial effects on bone cells. The goal of her research is to develop a human cell-based, functional, 3D in vitro model of bone. It should allow studying interactions between the various cell types within bone, but also the differences between cells from various (human) donors (healthy vs diseased, young vs aged). To address this, bioreactors have been developed for longitudinal imaging of the mineralized extracellular matrix development by cells, using micro-computed tomography. Computational approaches are used to describe these environments and to predict tissue formation in vitro. 

Academic background

Sandra Hofmann obtained her MSc in Pharmaceutical Sciences from the University of Basel, Switzerland in 2002. After a scientific visit to Prof. David Kaplan’s lab at Tufts University in Boston, she completed her PhD (with distinction) at the Swiss Federal Institute of Technology (ETH) in Zürich in 2007, working on 'Silk fibroin as a biomaterial for drug delivery and tissue engineering'. Subsequently, she moved to the Group of Prof. Ralph Müller at the ETH's Institute for Biomechanics to focus her studies on imaging methods and bioreactor design. In 2010 Hofmann became group leader of the Skeletal Tissue Engineering Group as a Senior Research Associate. She became an assistant professor at the Eindhoven University of Technology (TU/e) in 2013 and obtained tenure in 2016. Currently, she is an associate professor in Bioengineering Bone at the Orthopaedic Biomechanics Group and a core member of the Institute for Complex Molecular Systems (ICMS) at the TU/e. 

Among others, Sandra Hofmann has obtained an ERC starting grant (2013), a Marie Curie Career integration grant (2013), a Women in Science Grant (2014) and recently she was awarded an NWO Vidi grant (2018).

Affiliated with

· Orthopaedic Biomechanics Group (Biomedical Engineering Department, TU/e)

· Institute for Complex Molecular Systems (ICMS) 

 

Partners in (semi-)industry

· BonAlive

· Osteo-Pharma 

Externe posities

ETH Zurich

1 okt 200731 aug 2017

Vingerafdruk Duik in de onderzoeksthema's waar Sandra Hofmann actief is. Deze onderwerplabels komen voort uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.

  • 28 Vergelijkbare profielen
Scaffolds Engineering en materiaalwetenschappen
Bone Engineering en materiaalwetenschappen
Tissue Engineering Medicijnen en Levenswetenschappen
Fibroins Chemische stoffen
Tissue engineering Engineering en materiaalwetenschappen
Silk Chemische stoffen
Bone and Bones Medicijnen en Levenswetenschappen
Mesenchymal Stromal Cells Medicijnen en Levenswetenschappen

Netwerk Recente externe samenwerking op landenniveau. Duik in de details door op de stippen te klikken.

Onderzoeksoutput 2004 2020

16 Citaties (Scopus)
135 Downloads (Pure)

Flow velocity-driven differentiation of human mesenchymal stromal cells in silk fibroin scaffolds: A combined experimental and computational approach

Vetsch, J. R., Betts, D. C., Müller, R. & Hofmann, S., 1 jul 2017, In : PLoS ONE. 12, 7, 17 blz., e0180781.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Fibroins
fibroins
Fracture Healing
Silk
stromal cells
32 Citaties (Scopus)
2 Downloads (Pure)

Remodeling of tissue-engineered bone structures in vivo

Hofmann, S., Hilbe, M., Fajardo, R., Hagenmüller, H., Nuss, K., Arras, M., Müller, R., Rechenberg, von, B., Kaplan, D. L., Merkle, H. P. & Meinel, L., 2013, In : European Journal of Pharmaceutics and Biopharmaceutics. 85, 1, blz. 119-129

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Bone and Bones
Mesenchymal Stromal Cells
Fibroins
Bone Regeneration
Silk
265 Citaties (Scopus)
6 Downloads (Pure)

Control of in vitro tissue-engineered bone-like structures using human mesenchymal stem cells and porous silk scaffolds

Hofmann, S., Hagenmüller, H., Koch, A. M., Müller, R., Vunjak-Novakovic, G., Kaplan, D. L., Merkle, H. P. & Meinel, L., 2007, In : Biomaterials. 28, 6, blz. 1152-1162 11 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Silk
Stem cells
Mesenchymal Stromal Cells
Scaffolds
Fibroins
43 Citaties (Scopus)
3 Downloads (Pure)

Non-invasive time-lapsed monitoring and quantification of engineered bone-like tissue

Hagenmüller, H., Hofmann, S., Kohler, T., Merkle, H. P., Kaplan, D. L., Vunjak-Novakovic, G., Müller, R. & Meinel, L., 2007, In : Annals of Biomedical Engineering. 35, 10, blz. 1657-1667 11 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Bone
Tissue
Monitoring
Tomography
Minerals
558 Citaties (Scopus)

The inflammatory responses to silk films in vitro and in vivo

Meinel, L., Hofmann, S., Karageorgiou, V., Kirker-Head, C., McCool, J., Gronowicz, G., Zichner, L., Langer, R., Vunjak-Novakovic, G. & Kaplan, D. L., 2005, In : Biomaterials. 26, 2, blz. 147-155

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Silk
Collagen
Stem cells
Mesenchymal Stromal Cells
Interleukin-1beta

Prijzen

Intentional control of mineralized ECM deposition in bone tissue engineering

Sandra Hofmann (Ontvanger), 1 sep 2013

Prijs: AndersWerk, activiteit of publicatie gerelateerde prijzen (lifetime, best paper, poster etc.)Wetenschappelijk

Tissue Engineering
Bone and Bones

NWO Vidi Award : A miniature bone model

S. Hofmann (Ontvanger), 29 mei 2018

Prijs: NWOVidiWetenschappelijk

Bone and Bones
Bone Remodeling
Bone Diseases
Drug Therapy

Real-time monitoring of load induced remodeling in tissue-engineered bone

S. Hofmann (Ontvanger), 2013

Prijs: ERCStartingWetenschappelijk

Bone and Bones
Tissue Engineering
Pharmaceutical Preparations
Regenerative Medicine
Bone Remodeling

Cursussen

Basic tissue engineering

1/09/13 → …

Cursus

Biomaterialen

1/09/15 → …

Cursus

Bot structuur en functie

1/09/14 → …

Cursus

Pers/media

TU/e Researchers Discuss 'How to Become Tissue Engineer'

Anthal I.P.M. Smits, S. Hofmann & B. Fitzgerald

8/02/20

1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

REMOTE: Real-time monitoring of load induced remodeling in tissue-engineered bone

S. Hofmann

14/04/17

1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Scriptie

A 3D co-culture model of mesenchymal stem cells and endothelial cells to promote vascularization and osteogenesis in bone tissue engineering

Auteur: Cramer, E., 29 nov 2018

Begeleider: Melke, J. (Afstudeerdocent 1) & Hofmann, S. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Gas plasma modification for in situ tissue engineering

Auteur: Driessen, R., 31 mrt 2015

Begeleider: Bouten, C. (Afstudeerdocent 1), Sahlgren, C. (Afstudeerdocent 2), Hofmann Boss, S. (Afstudeerdocent 2), Smits, P. (Afstudeerdocent 2) & Stevens, A. (Externe persoon) (Externe coach)

Scriptie/masterproef: Master

Preparation of a 3D vascularized in vitro bone model using cell sheet engineering and a pre-seeded silk fibroin microtube vessel

Auteur: Vis, M., 28 mrt 2019

Begeleider: Melke, J. (Afstudeerdocent 1) & Hofmann, S. (Afstudeerdocent 2)

Scriptie/masterproef: Master

The effect of acidosis on osteoclastic bone resorption in 3D in vitro

Auteur: Sleddens, M., 31 aug 2017

Begeleider: Ito, K. (Afstudeerdocent 1), Hofmann Boss, S. (Afstudeerdocent 2), Tel, J. (Afstudeerdocent 2) & Remmers, S. (Afstudeerdocent 2)

Scriptie/masterproef: Master

The effect of testosterone and alendronate on bone formation in a 3D in vitro system

Auteur: van den Broek, E., 30 aug 2018

Begeleider: Ito, K. (Afstudeerdocent 1), Hofmann, S. (Afstudeerdocent 2), Melke, J. (Afstudeerdocent 2) & Kurniawan, N. (Afstudeerdocent 2)

Scriptie/masterproef: Master