• 1072 Citaten
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Persoonlijk profiel

Research profile

Richard Lopata is an Associate Professor at the TU/e research group Cardiovascular Biomechanics (department of Biomedical Engineering) where he leads the PULS/e lab, Photoacoustics & Ultrasound Laboratory Eindhoven.  The PULS/e lab facilitates research on technology development, such as ultrasound functional imaging, photoacoustics and image-based modeling; and more applied science, in particular ultrasound-based biomechanical modeling for improved clinical decision making.

In his research, Richard Lopata aims amongst others at the ultrasonic characterization of vulnerable arteries, such as aneurysms and plaques. A patient-specific biomechanical model of these arteries may help to better assess rupture risk, and ultrasound has the ability to provide highly detailed information on plaque geometry and distensibility. A second research line concerns the development and testing of 2-D and 3-D ultrasound imaging techniques for the assessment of cardiac function. The focus here is on acquisition, algorithms and methods that process the (raw) ultrasound data to produce measurements, needed in the clinic, and on methods to validate these measurements. These functional imaging techniques include motion/strain imaging, flow imaging and multi-perspective ultrasound imaging. Recent efforts are aimed at the assessment of cardiac function during exercise, together with USONO (spin-off company).

Photoacoustic imaging techniques, aimed at skin disease and plaque vulnerability assessment, are developed and validated in a preclinical setting.

Close collaborations with both clinical and technical partners were established over the years, paramount for a successful translation of these techniques from bench (lab) to bedside (clinic).

Academic background

Richard Lopata studied BioMedical Engineering at Eindhoven University of Technology (TU/e, The Netherlands) and received his MSc in 2004 on pharmacokinetic parameter estimation in dynamic contrast-enhanced MRI. From 2004-2009, Richard performed PhD research at the Clinical Physics Laboratory of Radboudumc (Nijmegen, The Netherlands), resulting in his PhD thesis on '2D and 3D Ultrasound Strain Imaging: Methods & In Vivo Applications'.

The following two years,he was a postdoctoral researcher at Maastricht University Medical Center (The Netherlands) and TU/e. In this period he was awarded a NWO-TTW VENI grant (2011).

In 2012, he became an assistant professor at TU/e. He works at the TU/e research group for Cardiovascular Biomechanics (department of Biomedical Engineering). Lopata founded the Photoacoustics and Ultrasound Laboratory Eindhoven, PULS/e. in 2014. In this period, Lopata was granted several EU-funded grants (FP7, H2020) and national grants.

In January 2017, he was appointed associate professor, receiving an ERC starting grant later that year. He has graduated over 35 MSc students and 1 PhD student, and is currently supervising 9 PhD students, two post-docs and 10 MSc students.

Vingerafdruk Duik in de onderzoeksthema's waar Richard G.P. Lopata actief is. Deze onderwerplabels komen voort uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.

  • 7 Vergelijkbare profielen
Elasticity Imaging Techniques Medicijnen en Levenswetenschappen
arteries Fysica en Astronomie
Ultrasonography Medicijnen en Levenswetenschappen
Ultrasonics Engineering en materiaalwetenschappen
Carotid Arteries Medicijnen en Levenswetenschappen
hemorrhages Fysica en Astronomie
Blood Vessels Medicijnen en Levenswetenschappen
Photoacoustic effect Engineering en materiaalwetenschappen

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Onderzoeksoutput 2004 2020

Open Access
Economic Inflation
Mechanical Properties
Blood Vessels

Reproducibility assessment of ultrasound-based aortic stiffness quantification and verification using Bi-axial tensile testing

van Disseldorp, E. M. J., van den Hoven, M. H. M. H., van de Vosse, F. N., van Sambeek, M. R. H. M. & Lopata, R. G. P., mrt 2020, In : Journal of the Mechanical Behavior of Biomedical Materials. 103, 10 blz., 103571.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Tensile testing

Ultrasound based wall stress analysis of abdominal aortic aneurysms using multiperspective imaging

van Disseldorp, E. M. J., van Dronkelaar, J. J., Pluim, J. P. W., van de Vosse, F. N., van Sambeek, M. R. H. M. & Lopata, R. G. P., 1 jan 2020, In : European Journal of Vascular and Endovascular Surgery. 59, 1, blz. 81-91 11 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Abdominal Aortic Aneurysm
Magnetic Resonance Imaging

Atherosclerotic carotid bifurcation phantoms with a stenotic soft inclusion for flow-structure ultrasound imaging analysis

Chayer, B., van den Hoven, M., Roy Cardinal, M. H., Li, H., Madiena, C., Swillens, A., Lopata, R. & Cloutier, G., okt 2019, 2019 IEEE International Ultrasonics Symposium, IUS 2019. Piscataway: IEEE Computer Society, blz. 1216-1218 3 blz. 8925928

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

mechanical properties
2 Citaties (Scopus)

Atherosclerotic carotid bifurcation phantoms with stenotic soft inclusions for ultrasound flow and vessel wall elastography imaging

Chayer, B., van den Hoven, M., Roy Cardinal, M. H., Li, H., Swillens, A., Lopata, R. & Cloutier, G., 2 mei 2019, In : Physics in Medicine and Biology. 64, 9, 12 blz., 095025.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Elasticity Imaging Techniques
Blood Vessels
Elastic Modulus
Internal Carotid Artery
Atherosclerotic Plaques


Multi-perspective Ultrasound Strain Imaging & Elastography

R.G.P. Lopata (Ontvanger), 2017

Prijs: ERCStartingWetenschappelijk

Elasticity Imaging Techniques
Aortic Valve Stenosis
Abdominal Aortic Aneurysm
Three-Dimensional Imaging


R.G.P. Lopata (Ontvanger), 2011

Prijs: NWOVeniWetenschappelijk


The stiffening of arteries viewed from multiple angles

Richard Lopata (Ontvanger), 2019

Prijs: NWOVidiWetenschappelijk

Blood Vessels


Two Vidi grants for research on cancer and aneurysms

Richard Lopata


1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Customization for patients with abdominal aneurysm based on 3D ultrasound imaging

Richard G.P. Lopata


3 items van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Customization for patients with abdominal aneurysm based on 3-D ultrasound imaging

R.G.P. Lopata


1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar


A constitutive material model to describe the mechanical behavior of human skin in shear, tensile and indentation tests

Auteur: Rooijakkers, T., 31 aug 2017

Begeleider: Oomens, C. (Afstudeerdocent 1), Loerakker, S. (Afstudeerdocent 2), Lopata, R. (Afstudeerdocent 2) & Soetens, J. (Afstudeerdocent 2)

Scriptie/masterproef: Master

An in-silico imaging system based on k-Wave for multi-perspective ultrasound imaging of abdominal aortic aneurysms

Auteur: Nooijens, S., 31 jan 2019

Begeleider: van de Vosse, F. (Afstudeerdocent 1), Lopata, R. (Afstudeerdocent 2), Oomens, C. (Afstudeerdocent 2), Petterson, N. (Afstudeerdocent 2) & Bouwman, R. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Assessing strain and damage in cartilage explants with ultrasound

Auteur: Stavenuiter, I., 31 jan 2019

Begeleider: Ito, K. (Afstudeerdocent 1), van Donkelaar, R. (Afstudeerdocent 2), Lopata, R. (Afstudeerdocent 2) & van de Vosse, F. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Correlation-based discrimination between myocardial tissue and blood in 3D echocardiographic images

Auteur: Saris, A., 30 apr 2012

Begeleider: Nillesen, M. M. (Externe persoon) (Externe coach), Lopata, R. (Afstudeerdocent 1), de Korte, C. (Externe coach) & van de Vosse, F. (Afstudeerdocent 2)

Scriptie/masterproef: Master