• 80 Citaties
20162020

Onderzoeksresultaten per jaar

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Persoonlijk profiel

Research profile

Rens de Vries started as a doctoral candidate at the Eindhoven University of Technology in September 2016 under the supervision of prof. Luc Brunsveld. In his research, he is exploring how small molecules influence the behavior of nuclear receptors, especially their effects on dimerization and cofactor recruitment. Nuclear receptors regulate the expression of specific genes, thereby controlling our development, homeostasis and metabolism. In multiple diseases, such as neurodegenerative diseases and cancer, the nuclear receptor function is altered. Selectively targeting these nuclear receptors and restoring their behavior, is very interesting in drug discovery. In the human body, processes such as dimerization and cofactor recruitment of these receptors are tightly and selectively mediated. How nature accomplished such a high degree of control is still poorly understood. Making use of protein crystallography, assay development and computational approaches, Rens tries to make his contribution to understand this interesting phenomenon and to potentially exploit it.

Academic background

Rens de Vries (1993) received his Bachelor and Master degree in Biomedical Engineering at Eindhoven University of Technology (TU/e) in 2014 and 2016 respectively. During his master, he performed research in the group of prof. dr. ir. Luc Brunsveld, under the direct supervision of dr. Christian Ottmann. In this research, the interaction between two proteins, important in Parkinson’s disease, was analyzed and quantified. This research was continued during his internship at the Lead Discovery Center GmbH in Dortmund where High-Throughput Screening and Assay Development were used to find drug candidates for this interaction. In 2016, he started as a PhD candidate under the supervision of prof. dr. ir. Luc Brunsveld in the field of Chemical Biology. In his research, he analyses how ligand design can fundamentally change the behavior of nuclear receptors.

Quote

If we desire the same level of precision as nature in drug development, we should not be interested in whether a drug works, we should strive to understand why it works.

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Onderzoeksoutput

  • 80 Citaties
  • 5 Tijdschriftartikel
  • 1 Artikel recenseren

Elucidation of an allosteric Mode of Action for a Thienopyrazole RORγt Inverse Agonist

de Vries, R. M. J. M., Doveston, R. G., Meijer, F. A. & Brunsveld, L., 3 apr 2020, In : ChemMedChem : chemistry enabling drug discovery. 15, 7, blz. 561-565 5 blz.

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  • 10 Downloads (Pure)

    Ligand-based design of allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists

    Meijer, F. A., Doveston, R. G., de Vries, R. M. J. M., Vos, G. M., Vos, A. A. A., Leysen, S., Scheepstra, M., Ottmann, C., Milroy, L-G. & Brunsveld, L., 9 jan 2020, In : Journal of Medicinal Chemistry. 63, 1, blz. 241-259 19 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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  • 1 Citaat (Scopus)
    26 Downloads (Pure)

    Allosteric small molecule modulators of nuclear receptors

    Meijer, F. A., Leijten-van de Gevel, I. A., de Vries, R. M. J. M. & Brunsveld, L., 5 apr 2019, In : Molecular and Cellular Endocrinology. 485, blz. 20-34 15 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

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  • 7 Citaten (Scopus)
    204 Downloads (Pure)

    Ligand dependent switch from RXR homo- to RXR-NURR1 heterodimerization

    Scheepstra, M., Andrei, S. A., de Vries, R. M. J. M., Meijer, F. A., Ma, J-N., Burstein, E. S., Olsson, R., Ottmann, C., Milroy, L-G. & Brunsveld, L., 1 sep 2017, In : ACS Chemical Neuroscience. 8, 9, blz. 2065-2077 13 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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  • 8 Citaten (Scopus)
    101 Downloads (Pure)

    Structural interface between LRRK2 and 14-3-3 protein

    Stevers, L. M., de Vries, R. M. J. M., Doveston, R. G., Milroy, L. G., Brunsveld, L. & Ottmann, C., 1 apr 2017, In : Biochemical Journal. 474, 7, blz. 1273-1287 15 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
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  • 16 Citaten (Scopus)
    228 Downloads (Pure)

    Prijzen

    Poster Prize

    Rens M.J.M. de Vries (Ontvanger), 7 feb 2020

    Prijs: AndersWerk, activiteit of publicatie gerelateerde prijzen (lifetime, best paper, poster etc.)Wetenschappelijk