• 32 Citaties
20182019

Onderzoeksresultaten per jaar

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Persoonlijk profiel

Quote

"Creating an enhanced vaccine formulation designed to eliminate bacterial infections"

Academic background

Pascal Welzen (Stein, 1990) received his MSc in Molecular Chemistry from Radboud University in 2016. During his Master traineeship he worked on the chemical synthesis of the MS2 viral capsid protein by solid phase peptide synthesis and native chemical ligation at the group of Jan van Hest (Radboud University). Before starting his Master education Pascal did his Bachelor internship at the TNO Eindhoven conducting research on self-healing thermos reversible bio based coatings. At the moment he is working as a PhD student on polymer assemblies for antigen display at the Bio-organic Chemistry department (Jan van Hest) based at the Eindhoven University of Technology (TU/e).

Research profile

Polymer assemblies for antigen display

Polymersomes are an interesting group of polymeric vesicles. Due to their ability to encapsulate cargo, e.g. antigen/peptides, it is possible to use polymersomes for drug delivery systems. By altering the composition of the block copolymer it is possible to control the polymersome size and membrane thickness and, consequently, the drug release profile. A cocktail of different sized polymersomes with various membrane thicknesses creates a multi stage drug release profile enhancing immune response. Furthermore, by functionalizing the outer membrane with bioactive compounds targeted delivery of these vesicles is enhanced. 

The main focus of this project is to create a system able to encapsulate, carry, target and release streptococcal antigens and peptides, focused on creating an enhanced vaccine formulation designed to eliminate bacterial infections.

Vingerafdruk Verdiep u in de onderzoeksgebieden waarop Pascal Welzen actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.

  • 4 Soortgelijke profielen

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Onderzoeksoutput

  • 32 Citaties
  • 2 Tijdschriftartikel

Mimicking cellular compartmentalization in a hierarchical protocell through spontaneous spatial organization

Mason, A. F., Yewdall, A., Welzen, P. L. W., Shao, J., van Stevendaal, M., van Hest, J. C. M., Williams, D. S. & Abdelmohsen, L. K. E. A., 28 aug 2019, In : ACS Central Science. 5, 8, blz. 1360-1365 6 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
  • 16 Citaten (Scopus)
    44 Downloads (Pure)

    Biodegradable synthetic organelles demonstrate ROS shielding in human-complex-I-deficient fibroblasts

    van Oppen, L. M. P. E., Abdelmohsen, L. K. E. A., van Emst-de Vries, S. E., Welzen, P. L. W., Wilson, D. A., Smeitink, J. A. M., Koopman, W. J. H., Brock, R., Willems, P. H. G. M., Williams, D. S. & van Hest, J. C. M., 25 jul 2018, In : ACS Central Science. 4, 7, blz. 917-928 12 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
    Bestand
  • 16 Citaten (Scopus)
    96 Downloads (Pure)

    Activiteiten

    Dutch Peptide Symposium - 2015

    Pascal Welzen (Organisator)

    27 mei 2015

    Activiteit: Types deelname aan of organisatie van een evenementCongresWetenschappelijk

    Knipsels

    Innovative One-Health approaches in bacterial vaccine development

    Jan C.M. Hest, van & Pascal Welzen

    13/11/19

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