Projecten per jaar
Persoonlijk profiel
Research profile
Nicholas Kurniawan is an Associate Professor in the Soft Tissue Engineering and Mechanobiology group. His research focuses on understanding why and how cells behave the way they do in different physical environments. To answer this question, he creates biomimetic cellular environments at multiple scales—from 2D micropatterns to 3D extracellular matrices and bioreactors—where every physical and mechanical cues to the cells can be precisely controlled. These in vitro platforms enable him to systematically break down the origins of basic cellular behavior, such as orientation, migration, and differentiation. The overarching goal is to use the obtained insights to direct cell response in vivo, for example to promote tissue regeneration or to slow down disease progression. Nicholas’s research is highly interdisciplinary, encompassing biophysics, cell biology, protein polymers, biomechanics, and soft matter.
Academic background
Nicholas Kurniawan received his PhD in 2012 from the National University of Singapore (Singapore), studying the role of matrix viscoelasticity in cancer metastasis. He then carried out postdoctoral research as a Marie Curie Fellow at AMOLF (Amsterdam, the Netherlands), investigating the hierarchical structure-property relation in the cytoskeleton and extracellular matrices. In 2015, he joined Eindhoven University of Technology (TU/e) in Eindhoven, the Netherlands, in the research group Soft Tissue Engineering and Mechanobiology (department of Biomedical Engineering). He is also a member of the Institute for Complex Molecular Systems (ICMS).
Quote
The cell is a physical entity that interacts with its surrounding objects. By smartly designing the cellular environment, we essentially can have a remote control for steering cell behavior.
Expertise gerelateerd aan duurzame ontwikkelingsdoelstellingen van de VN
In 2015 stemden de VN-lidstaten in met 17 wereldwijde duurzame ontwikkelingsdoelstellingen (Sustainable Development Goals, SDG's) om armoede te beëindigen, de planeet te beschermen en voor iedereen welvaart te garanderen. Het werk van deze persoon draagt bij aan de volgende duurzame ontwikkelingsdoelstelling(en):
Vingerafdruk
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Projecten
- 1 Afgelopen
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Advaessel: Ad vanced materials processing and design for regenerating blodd vessels
Kurniawan, N. A. (Project Manager) & Castilho, M. (Projectmedewerker)
1/11/20 → 30/11/21
Project: Onderzoek direct
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Dynamic substrate topographies drive actin- and vimentin-mediated nuclear mechanoprotection events in human fibroblasts
Bril, M., Boesveld, J. N., Coelho-Rato, L. S., Sahlgren, C. M., Bouten, C. V. C. & Kurniawan, N. A. (Corresponding author), 7 apr. 2025, In: BMC Biology. 23, 1, 16 blz., 94.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand6 Downloads (Pure) -
Digital Photoinduced Topographical Microsculpting of Hydrogels
Bril, M., D'Urso, M., Prejanò, M., Costantini, M., Angeloni, L. & Kurniawan, N. A. (Corresponding author), 2 dec. 2024, In: Advanced Materials Technologies. 9, 23, 11 blz., 2400721.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand1 Citaat (Scopus)18 Downloads (Pure) -
Dimensionality Matters: Exploiting UV-Photopatterned 2D and Two-Photon-Printed 2.5D Contact Guidance Cues to Control Corneal Fibroblast Behavior and Collagen Deposition
van der Putten, C., Sahin, G., Grant, R., D'Urso, M., Giselbrecht, S., Bouten, C. V. C. & Kurniawan, N. A. (Corresponding author), apr. 2024, In: Bioengineering. 11, 4, 18 blz., 402.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand2 Citaten (Scopus)41 Downloads (Pure) -
Spatial regulation of substrate adhesion directs fibroblast morphotype and phenotype
D'Urso, M., Jorba, I., van der Pol, A., Bouten, C. V. C. & Kurniawan, N. A. (Corresponding author), aug. 2024, In: PNAS Nexus. 3, 8, 11 blz., pgae289.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand3 Citaten (Scopus)36 Downloads (Pure) -
Steering cell orientation through light-based spatiotemporal modulation of the mechanical environment
Jorba, I. (Corresponding author), Gussenhoven, S., van der Pol, A., Groenen, B. G. W., van Zon, M., Goumans, M. J., Kurniawan, N. A., Ristori, T. & Bouten, C. V. C., 1 jul. 2024, In: Biofabrication. 16, 3, 19 blz., 035011.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand5 Citaten (Scopus)67 Downloads (Pure)
Datasets
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Supplementary material from "Mesoscale substrate curvature overrules nanoscale contact guidance to direct bone marrow stromal cell migration"
Werner, M. (Ontwerper), Kurniawan, N. A. (Ontwerper), Korus, G. (Ontwerper), Bouten, C. V. C. (Ontwerper) & Petersen, A. (Ontwerper), Figshare, 23 jul. 2018
DOI: 10.6084/m9.figshare.c.4174829, https://figshare.com/collections/Supplementary_material_from_Mesoscale_substrate_curvature_overrules_nanoscale_contact_guidance_to_direct_bone_marrow_stromal_cell_migration_/4174829 en nog één link, https://figshare.com/collections/Supplementary_material_from_Mesoscale_substrate_curvature_overrules_nanoscale_contact_guidance_to_direct_bone_marrow_stromal_cell_migration_/4174829/1 (minder tonen)
Dataset
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Data underlying the publication: Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue
van Haaften, E. E. (Bijdrager), Kurniawan, N. A. (Bijdrager), Bouten, C. V. C. (Bijdrager), Quicken, S. (Bijdrager) & Huberts, W. (Bijdrager), 4TU.Centre for Research Data, 29 mrt. 2021
DOI: 10.4121/14292383
Dataset
Prijzen
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Control cell communication and tissue regeneration
Kurniawan, N. (Ontvanger), 2019
Prijs: ERC › Starting › Wetenschappelijk
Cursussen
Knipsels
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Research from Eindhoven University of Technology in the Area of Smart Materials in Medicine Described (Stimuli-responsive materials: A smart way to study dynamic cell responses)
16/02/23
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