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Persoonlijk profiel

Research profile

Nicholas Kurniawan is an Assistant Professor in the Soft Tissue Engineering and Mechanobiology group. His research focuses on understanding why and how cells behave the way they do in different physical environments. To answer this question, he creates biomimetic cellular environments at multiple scales—from 2D micropatterns to 3D extracellular matrices and bioreactors—where every physical and mechanical cues to the cells can be precisely controlled. These in vitro platforms enable him to systematically break down the origins of basic cellular behavior, such as orientation, migration, and differentiation. The overarching goal is to use the obtained insights to direct cell response in vivo, for example to promote tissue regeneration or to slow down disease progression. Nicholas’s research is highly interdisciplinary, encompassing biophysics, cell biology, protein polymers, biomechanics, and soft matter.

Academic background

Nicholas Kurniawan received his PhD in 2012 from the National University of Singapore (Singapore), studying the role of matrix viscoelasticity in cancer metastasis. He then carried out postdoctoral research as a Marie Curie Fellow at AMOLF (Amsterdam, the Netherlands), investigating the hierarchical structure-property relation in the cytoskeleton and extracellular matrices. In 2015, he joined Eindhoven University of Technology (TU/e) in Eindhoven, the Netherlands, as an Assistant Professor in the research group Soft Tissue Engineering and Mechanobiology (department of Biomedical Engineering). He is also a member of the Institute for Complex Molecular Systems (ICMS).

Quote

The cell is a physical entity that interacts with its surrounding objects. By smartly designing the cellular environment, we essentially can have a remote control for steering cell behavior.

Vingerafdruk Duik in de onderzoeksthema's waar Nicholas A. Kurniawan actief is. Deze onderwerplabels komen voort uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.

  • 11 Vergelijkbare profielen
Tissue Chemische stoffen
Blood Vessels Medicijnen en Levenswetenschappen
fibrin Fysica en Astronomie
Grafts Chemische stoffen
Tissue engineering Chemische stoffen
Tissue Engineering Medicijnen en Levenswetenschappen
Cell Movement Medicijnen en Levenswetenschappen
Biophysics Medicijnen en Levenswetenschappen

Netwerk Recente externe samenwerking op landenniveau. Duik in de details door op de stippen te klikken.

Onderzoeksoutput 2010 2020

  • 402 Citaten
  • 37 Tijdschriftartikel
  • 4 Meeting Abstract
  • 3 Poster
  • 2 Artikel recenseren
8 Downloads (Pure)
Open Access
Bestand
Macrophages
Hemodynamics
Biocompatible Materials
Tissue engineering
Biomaterials
3 Downloads (Pure)

Layer-specific cell differentiation in bi-layered vascular grafts under flow perfusion

Pennings, I., van Haaften, E. E., Juengst, T., Bulsink, J. A., Rosenberg, A. J. W. P., Groll, J., Bouten, C. V. C., Kurniawan, N. A., Smits, A. I. P. M. & Gawlitta, D., jan 2020, In : Biofabrication. 12, 1, 13 blz., 015009.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Grafts
Blood Vessels
Cell Differentiation
Perfusion
Transplants
1 Citaat (Scopus)
11 Downloads (Pure)

A stirring system using suspended magnetically-actuated pillars for controlled cell clustering

Saberi, A., Zhang, S., van den Bersselaar, C., Kandail, H., den Toonder, J. M. J. & Kurniawan, N. A., 14 feb 2019, In : Soft Matter. 15, 6, blz. 1435-1443 9 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
stirring
Magnetic scales
Colloids
Research laboratories
cells
1 Citaat (Scopus)
19 Downloads (Pure)

Cell-perceived substrate curvature dynamically coordinates the direction, speed, and persistence of stromal cell migration

Werner, M., Petersen, A., Kurniawan, N. & Bouten, C., 5 sep 2019, In : Advanced Biosystems. 3, 10, 11 blz., 1900080.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Stromal Cells
Cell Movement
Mesenchymal Stromal Cells
Bone
Biocompatible Materials
3 Citaties (Scopus)
28 Downloads (Pure)

Entropic forces drive cellular contact guidance

Buskermolen, A. B. C., Suresh, H., Shishvan, S. S., Vigliotti, A., DeSimone, A., Kurniawan, N. A., Bouten, C. V. C. & Deshpande, V. S., 21 mei 2019, In : Biophysical Journal. 116, 10, blz. 1994-2008 15 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Stress Fibers
Entropy
Cell Size
Cell Nucleus Shape
Cell Nucleus Size

Prijzen

Control cell communication and tissue regeneration

Nicholas Kurniawan (Ontvanger), 2019

Prijs: ERCStartingWetenschappelijk

Cell Communication
Regeneration
Extracellular Matrix
Cardiomyopathies
Communication

Cursussen

Hart en bloed

1/09/15 → …

Cursus

Thermodynamica

1/09/15 → …

Cursus

Scriptie

A brain chip to investigate neurite outgrowth by trapping cell-laden hydrogel beads in microsieves

Auteur: Labeur, T., 29 aug 2019

Begeleider: Bouten, C. (Afstudeerdocent 1), Luttge, R. (Afstudeerdocent 2), Kurniawan, N. (Afstudeerdocent 2) & Bastiaens, A. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Cell directed nanoparticle drug delivery for tissue engineering

Auteur: Vogel, M., 30 sep 2015

Begeleider: Bouten, C. (Afstudeerdocent 1), Sahlgren, C. (Afstudeerdocent 2), Ottmann, C. (Afstudeerdocent 2) & Kurniawan, N. (Externe coach)

Scriptie/masterproef: Master

Design of a DNA-based tension probe for the quantification of cellular traction forces at a molecular level

Auteur: van der Putten, C., 25 jan 2018

Begeleider: Kurniawan, N. (Afstudeerdocent 1), de Greef, T. (Afstudeerdocent 2) & Bouten, C. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Endothelium outgrowth under flow: a study of the outgrowth of endothelial monolayers under high shear rates

Auteur: Vlemmings, D., 28 feb 2019

Begeleider: Kurniawan, N. (Afstudeerdocent 1) & van Haaften, E. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Evaluation of the potential of cell-laden chondroitin sulfate methacrylate hydrogels for cartilage regeneration

Auteur: Nijhuis, M., 25 okt 2018

Begeleider: Ito, K. (Afstudeerdocent 1), van Donkelaar, C. (Afstudeerdocent 2), van Hooijdonk - Mouser, V. (Afstudeerdocent 2), Vermonden, T. (Externe persoon) (Externe coach) & Kurniawan, N. (Afstudeerdocent 2)

Scriptie/masterproef: Master