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Persoonlijk profiel

Research profile

Nicholas Kurniawan is an Assistant Professor in the Soft Tissue Engineering and Mechanobiology group. His research focuses on understanding why and how cells behave the way they do in different physical environments. To answer this question, he creates biomimetic cellular environments at multiple scales—from 2D micropatterns to 3D extracellular matrices and bioreactors—where every physical and mechanical cues to the cells can be precisely controlled. These in vitro platforms enable him to systematically break down the origins of basic cellular behavior, such as orientation, migration, and differentiation. The overarching goal is to use the obtained insights to direct cell response in vivo, for example to promote tissue regeneration or to slow down disease progression. Nicholas’s research is highly interdisciplinary, encompassing biophysics, cell biology, protein polymers, biomechanics, and soft matter.

Academic background

Nicholas Kurniawan received his PhD in 2012 from the National University of Singapore (Singapore), studying the role of matrix viscoelasticity in cancer metastasis. He then carried out postdoctoral research as a Marie Curie Fellow at AMOLF (Amsterdam, the Netherlands), investigating the hierarchical structure-property relation in the cytoskeleton and extracellular matrices. In 2015, he joined Eindhoven University of Technology (TU/e) in Eindhoven, the Netherlands, as an Assistant Professor in the research group Soft Tissue Engineering and Mechanobiology (department of Biomedical Engineering). He is also a member of the Institute for Complex Molecular Systems (ICMS).

Quote

The cell is a physical entity that interacts with its surrounding objects. By smartly designing the cellular environment, we essentially can have a remote control for steering cell behavior.

Vingerafdruk Verdiep u in de onderzoeksgebieden waarop Nicholas A. Kurniawan actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.

  • 24 Soortgelijke profielen

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Onderzoeksoutput

  • 412 Citaties
  • 34 Tijdschriftartikel
  • 4 Meeting Abstract
  • 3 Poster
  • 3 Artikel recenseren

Cellular geometry sensing at different length scales and its implications for scaffold design

Werner, M., Kurniawan, N. A. & Bouten, C. V. C., 21 feb 2020, In : Materials. 13, 4, 18 blz., 963.

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

Open Access
Bestand
  • 11 Downloads (Pure)
    Open Access
    Bestand
  • 14 Downloads (Pure)

    Layer-specific cell differentiation in bi-layered vascular grafts under flow perfusion

    Pennings, I., van Haaften, E. E., Juengst, T., Bulsink, J. A., Rosenberg, A. J. W. P., Groll, J., Bouten, C. V. C., Kurniawan, N. A., Smits, A. I. P. M. & Gawlitta, D., 1 jan 2020, In : Biofabrication. 12, 1, 13 blz., 015009.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • 1 Citaat (Scopus)
    4 Downloads (Pure)

    A stirring system using suspended magnetically-actuated pillars for controlled cell clustering

    Saberi, A., Zhang, S., van den Bersselaar, C., Kandail, H., den Toonder, J. M. J. & Kurniawan, N. A., 14 feb 2019, In : Soft Matter. 15, 6, blz. 1435-1443 9 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
    Bestand
  • 1 Citaat (Scopus)
    17 Downloads (Pure)

    Cell-perceived substrate curvature dynamically coordinates the direction, speed, and persistence of stromal cell migration

    Werner, M., Petersen, A., Kurniawan, N. & Bouten, C., 5 sep 2019, In : Advanced Biosystems. 3, 10, 11 blz., 1900080.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    Open Access
    Bestand
  • 2 Citaten (Scopus)
    25 Downloads (Pure)

    Prijzen

    Control cell communication and tissue regeneration

    Nicholas Kurniawan (Ontvanger), 2019

    Prijs: ERCStartingWetenschappelijk

  • Cursussen

    Hart en bloed

    1/09/15 → …

    Cursus

    Thermodynamica

    1/09/1531/08/20

    Cursus

    Scriptie

    A brain chip to investigate neurite outgrowth by trapping cell-laden hydrogel beads in microsieves

    Auteur: Labeur, T., 29 aug 2019

    Begeleider: Bouten, C. (Afstudeerdocent 1), Luttge, R. (Afstudeerdocent 2), Kurniawan, N. (Afstudeerdocent 2) & Bastiaens, A. (Afstudeerdocent 2)

    Scriptie/masterproef: Master

    Cell directed nanoparticle drug delivery for tissue engineering

    Auteur: Vogel, M., 30 sep 2015

    Begeleider: Bouten, C. (Afstudeerdocent 1), Sahlgren, C. (Afstudeerdocent 2), Ottmann, C. (Afstudeerdocent 2) & Kurniawan, N. (Externe coach)

    Scriptie/masterproef: Master

    Design of a DNA-based tension probe for the quantification of cellular traction forces at a molecular level

    Auteur: van der Putten, C., 25 jan 2018

    Begeleider: Kurniawan, N. (Afstudeerdocent 1), de Greef, T. (Afstudeerdocent 2) & Bouten, C. (Afstudeerdocent 2)

    Scriptie/masterproef: Master

    Endothelium outgrowth under flow: a study of the outgrowth of endothelial monolayers under high shear rates

    Auteur: Vlemmings, D., 28 feb 2019

    Begeleider: Kurniawan, N. (Afstudeerdocent 1) & van Haaften, E. (Afstudeerdocent 2)

    Scriptie/masterproef: Master

    Evaluation of the potential of cell-laden chondroitin sulfate methacrylate hydrogels for cartilage regeneration

    Auteur: Nijhuis, M., 25 okt 2018

    Begeleider: Ito, K. (Afstudeerdocent 1), van Donkelaar, C. (Afstudeerdocent 2), van Hooijdonk - Mouser, V. (Afstudeerdocent 2), Vermonden, T. (Externe persoon) (Externe coach) & Kurniawan, N. (Afstudeerdocent 2)

    Scriptie/masterproef: Master