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Onderzoeksoutput 2000 2019

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2016

A mathematical model for investigation of intestinal changes on the postprandial bile acid profile

Sips, F. L. P., Eggink, H. M., Hilbers, P. A. J., Soeters, M. R., Groen, B. & van Riel, N. A. W., 2016, Book of abstracts of BioSB 2016. blz. 32 1 blz.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Open Access
Bestand

A mathematical model of the intestinal transit and enterohepatic circulation of bile acids

Sips, F. L. P., Eggink, H. M., Hilbers, P. A. J., Soeters, M. R., Groen, A. K. & van Riel, N. A. W., 2016, Abstracts of the XXIV International Bile Acid Meeting: Bile Acids in Health and Disease. Freiburg: Falk Foundation , blz. 135 1 blz. 69

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Open Access
Bestand
2015

ADAPT: analysis of dynamic adaptations in parameter trajectories

Riel, van, N. A. W., 5 feb 2015, Data Integration in the Life Sciences, 5 februari 2015, Leiden, The Netherlands. s.l.: s.n.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageProfessioneel

A systems biology approach reveals the physiological origin of increased plasma HDL levels and hepatic steatosis induced by liver X receptor activation

Riel, van, N. A. W., 10 feb 2015, Proceedings of the Keystone Symposia Systems Biology of Lipid Metabolism (B4), 9-13 February 2014, Breckenridge, Colorado. s.l.: s.n.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Systems Biology
Fatty Liver
Liver
HDL Cholesterol
Triglycerides

Dynamical modelling of the development of Metabolic Syndrome through longitudinal data integration using ADAPT

Rozendaal, Y. J. W., Wang, Y., Willems Van Dijk, K., Rensen, P. C. N., Groen, A. K., Hilbers, P. A. J. & van Riel, N. A. W., 2015, BME Research Day, 17 April 2015, Eindhoven, The Netherlands. Eindhoven

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Modelling metabolic fluxes

Riel, van, N. A. W., 22 apr 2015, Counterstrike Kick-Off Seminar, 22 April 2015, Copenhagen, Denmark.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Systems medicine of metabolic syndrome and its comorbidities

Riel, van, N. A. W., 6 jul 2015, CASyM workshop - Endocrine, Metabolic and Digestive disorders : Challenges and Opportunities of a Systems Medicine approach, 5-7 July 2015, Genoa, Italy.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

2014

Blue light phototherapy for Psoriasis from a systems biology perspective

Félix Garza, Z. C., Liebmann, J., Hilbers, P. A. J. & Riel, van, N. A. W., 2014, Proceedings of the SB@NL2014 Symposium (Systems Biology: Tackling Complexity through Data Integration), 15-16 December 2014, Maastricht, The Netherlands. blz. 43-44

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Open Access
Bestand
Phototherapy
Systems Biology
Psoriasis
Light
Keratinocytes

Dynamical modelling of the onset and progression of the metabolic syndrome through longitudinal data integration using ADAPT

Rozendaal, Y. J. W., Wang, Y., Willems Van Dijk, K., Rensen, P. C. N., Groen, A. K., Hilbers, P. A. J. & Riel, van, N. A. W., 2014, Proceedings of the SB@NL2014 Symposium (Systems Biology: Tackling Complexity through Data Integration), 15-16 December 2014, Maastricht, The Netherlands. Maastricht, blz. 63-64

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

E-DES : Eindhoven Diabetes Education Simulator

Maas, A. H., Pul, van, C., Cottaar, E. J. E., Chen, W., Hilbers, P. A. J., Riel, van, N. A. W. & Haak, H. R., 2014, Annual Meeting of the Young Investigators of the Dutch Association for Diabetes Research 2015, 30-31 Januari 2015.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Education

E-DES : Eindhoven Diabetes Education Simulator

Maas, A. H., Pul, van, C., Cottaar, E. J. E., Hilbers, P. A. J., Riel, van, N. A. W. & Haak, H. R., 2014, Games for Health Europe 2014, 27-28 October 2014, 27-28 October 2014, Utrecht, The Netherlands.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Education

The Eindhoven Diabetes Education Simulator (e/DES)

Riel, van, N. A. W., 2014, Symposium ‘The Soft Machine – the future of high tech in health care’, Eindhoven.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Using predictive differences to design experiments for model selection

Vanlier, J., Tiemann, C. A., Timmer, J., Hilbers, P. A. J. & Riel, van, N. A. W., 2014, 5th Conference on Systems Biology of Mammalian Cells (SBMC2014), 12-14 May 2014, Berlin, Germany. blz. 50-51

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Experiments
Computational complexity
Mathematical models
2013

Analysis of dynamics and feedbacks in insulin-mediated GLUT4 translocation

Colmekci, C., Hilbers, P. A. J. & Riel, van, N. A. W., 2013, Proceedings of the 14th International Conference on Systems Biology, August 30- September 3, 2013, Copenhagen, Denmark.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Experimental observations on glycolysis in muscle: revisiting physiological versus biochemical regulation in the study of metabolic pathway topology and function

Jeneson, J. A. L., Schmitz, J. P. J. & Riel, van, N. A. W., 2013, 4th Metabolic Pathway Analysis Conference (MPA), 16-20 september 2013, Oxford, Great Britain.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Incorporating different food products and composite meals in the Eindhoven Diabetes Education Simulator

Maas, A. H., Rozendaal, Y. J. W., Pul, van, C., Cottaar, E. J. E., Hilbers, P. A. J., Riel, van, N. A. W. & Haak, H. R., 2013, Annual Dutch Diabetes Research Meeting 2013. blz. PS15-1-

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Open Access
Bestand

Systems Medicine and Metabolic Diseases

Riel, van, N. A. W., 2013, Department of Biomedical Engineering Research Day 2013.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Systems medicine and metabolic profiling of diseases

Riel, van, N. A. W., 2013, Proceedings of the 2nd International Conference and Exhibition on Metabolomics and Systems Biology, 8-10 April 2013, Chicago, Illinois. Chicago

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Use of genome-scale metabolic models for plant metabolism

Yuan, H., Wijnen, B., Zhou, G., Hilbers, P. A. J. & Riel, van, N. A. W., 2013, The Metabolic Pathway Analysis Conference(MPAC) 16-20th September 2013, Oxford, UK..

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Open Access
Bestand
genome
metabolism
respiration
sucrose
carbohydrate
2012

A biophysical model of spatiotemporal ATP buffering in a skeletal muscle sarcomere

Jeneson, J. A. L., Wijnen, B., Schmitz, J. P. J., Hilbers, C. W. & Riel, van, N. A. W., 2012, Proceedings of the 15th Workshop of the International Study Group for Systems Biology (ISGSB 2012), 24-28 September 2012, Groningen and Ameland, The Netherlands.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Sarcomeres
Skeletal Muscle
Adenosine Triphosphate
Adenosine Diphosphate
Creatine Kinase

A computational framework to analyze plasma lipoprotein metabolism in mice

Sips, F. L. P., Tiemann, C. A., Hilbers, C. W. & Riel, van, N. A. W., 2012, Abstract presented at the 4th Conference on Systems Biology of Mammalian Cells (SBMC) 2012, 9-11 July 2012, Leipzig, Germany.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Lipoproteins
Triglycerides
VLDL Lipoproteins
Cholesterol
HDL Lipoproteins

A computational strategy to predict treatment effects of pharmacological interventions

Tiemann, C. A., Vanlier, J., Hilbers, P. A. J. & Riel, van, N. A. W., 2012, International Study Group for Systems Biology 2012, 25-28 September 2012, Ameland, The Netherlands. Ameland, The Netherlands

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Challenges and opportunities for modeling signal transduction pathways using immunohistochemistry data

Colmekci, C., Vanlier, J., Hilbers, P. A. J. & Riel, van, N. A. W., 2012, Book of Abstracts of the 4th Conference on Systems Biology on Mammalian Cells (SBMC), 9–11 July 2012, Leipzig, Germany.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Open Access
Bestand

Computational modeling of horticultural crops under different light conditions

Wijnen, B., Yuan, H., Hilbers, P. A. J., Ren, Y., Zhou, G., Yu, J. & Riel, van, N. A. W., 2012, Proceedings of the 15th Workshop of the International Study Group for Systems Biology (ISGSB 2012), 24-28 September 2012, Groningen and Ameland, The Netherlands.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

horticultural crops
biomass production
catalase
Arabidopsis
enzymes

Designing optimal experiments to identify progressive adaptations in biological systems

Vanlier, J., Tiemann, C. A., Hilbers, P. A. J. & Riel, van, N. A. W., 2012, Paper presented at the NCSB 2012 Symposium : Systems biology : from models and data to real life applications, 1-2 November 2012, Soesterberg, The Netherlands.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

In vivo magnetic resonance spectroscopy of lipid handling in steatotic rat liver

Janssens, S. M. M., Jonkers, R. A. M., Riel, van, N. A. W., Nicolay, K. & Prompers, J. J., 2012, Experimental Biology 2012 : San Diego, April 21-25, 2012. blz. 242.7- (FASEB Journal : The Journal of the Federation of American Societies for Experimental Biology; vol. 26)

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Open Access
Bestand
Magnetic Resonance Spectroscopy
Lipids
Liver
High Fat Diet
Fats

Modelling progressive metabolic diseases with parameter transition trajectories

Riel, van, N. A. W., 2012, Proceedings of the Virtual Physiological Human Conference (VPH) 2012, 18-20 September 2012, London, United Kingdom.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Optimal experiment design for targeting specific predictions of interest

Vanlier, J., Tiemann, C. A., Hilbers, P. A. J. & Riel, van, N. A. W., 2012, Proceedings of the Workshop Parameter Estimation and Uncertainty Analysis in Systems Biology, 7 June 2012, Eindhoven. Riel, van, N. A. W. (redactie). Eindhoven

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Targeted experiment design using the posterior predictive distribution

Vanlier, J., Tiemann, C. A., Hilbers, P. A. J. & Riel, van, N. A. W., 2012, Presentation at workshop "Parameter Estimation for Dynamical Systems" (PEDS-II), June 4-6-, 2012, Eindhoven, The Netherlands. Eindhoven: Eurandom, blz. 21-22

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Open Access
Bestand
experiment design

Unravelling the kinetics of insulin signalling in skeletal muscle cells

Colmekci, C., Vanlier, J., Hilbers, P. A. J. & Riel, van, N. A. W., 2012, Proceedings of the Annual Dutch Diabetes Research Meeting, November 29-30, 2012, Oosterbeek, The Netherlands.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

2011

A Bayesian approach to predictions despite uncertainties

Vanlier, J., Tiemann, C. A., Hilbers, P. A. J. & Riel, van, N. A. W., 2011, Presentation at the Conclusions Despite Uncertainties Workshop, 18-19 June 2011, Linkoping, Sweden. Linkoping, Sweden

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Biosimulation in pharmacy: a tool to predict control points in obesity-related impaired insulin signaling

Colmekci, C., Liu, H., Hilbers, P. A. J. & Riel, van, N. A. W., 2011, Proceedings of the Biomedica Conference 2011, 7-8 April 2011, Eindhoven, The Netherlands.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Exploring the effects of snare proteins on insulin signaling cascade in skeletal muscle via computational modeling

Colmekci, C., Liu, H., Hilbers, P. A. J. & Riel, van, N. A. W., 2011, Proceedings of the FEBS-SystemsX-SysBio2011: From Molecules To Function, 26 February - 4 March 2011, Innsbruck, Austria.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Kinetic analysis of liver X receptor induced hepatic steatosis

Tiemann, C. A., Vanlier, J., Hilbers, P. A. J. & Riel, van, N. A. W., 2011, Proceedings of Lipid Biology and Lipotoxicity (E2), 15-20 May 2011, Killarney, Ireland. Killarney, Ireland

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Liver X receptor induced metabolic adaptations: testing of model predictions

Tiemann, C. A., Vanlier, J., Groen, A. K., Hilbers, P. A. J. & Riel, van, N. A. W., 2011, The Full System Biology Cycle : Proceedings of the NSCB symposium 2011, 31 October - 1 November 2011, Soesterberg, The Netherlands.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Predicting parameter development in progressive diseases

Tiemann, C. A., Vanlier, J., Jeneson, J. A. L., Hilbers, P. A. J. & Riel, van, N. A. W., 2011, Proceedings of the 3rd Dutch Bio-Medical Engineering Conference (BME 2011), 20-21 January 2011, Egmond aan Zee, The Netherlands.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Quantitative analyses of muscle metabolism to predict metabolic diseases

Schmitz, J. P. J., Jeneson, J. A. L., Prompers, J. J., Nicolay, K., Hilbers, P. A. J. & Riel, van, N. A. W., 2011, Proceedings of Biomedica 2011, 7-8 April 2011, Eindhoven, The Netherlands.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Quantitative exploration of hypotheses on lipid induced impaired insulin signaling in skeletal muscle

Colmekci, C., Hilbers, P. A. J. & Riel, van, N. A. W., 2011, Proceeding of the Keystone Symposia: Lipid Biology and Lipotoxicity (E2). 15-20 May 2011, Killarney, Ireland.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Strategies for parameter uncertainty analysis

Vanlier, J., Tiemann, C. A., Jeneson, J. A. L., Hilbers, P. A. J. & Riel, van, N. A. W., 2011, Presentation at the 5th Workshop on Monte Carlo Method, 14 January 2011, Heidelberg, Germany. Heidelberg

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

uncertainty analysis
parameter
Markov chain
prediction
parameterization
2010

A computational approach to relate muscle phenotype to in vivo mitochondrial function

Schmitz, J. P. J., Riel, van, N. A. W., Nicolay, K., Hilbers, P. A. J. & Jeneson, J. A. L., 2010, Proceedings of the Experimental Biology 2010, 24-28 April 2010, Anaheim, California, USA.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

A computational model of hepatic lipid metabolism : identifying persistent behavior

Tiemann, C. A., Vanlier, J., Jeneson, J. A. L., Hilbers, P. A. J. & Riel, van, N. A. W., 2010, Proceedings of the Conference on Systems Biology of Mammalian Cells (SBMC 2010), 3-5 June 2010, Freiburg, Germany. Germany, Freiburg

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Open Access
Bestand
Lipid Metabolism
Liver

A computational study of liver X receptor induced hepatic steatosis

Tiemann, C. A., Vanlier, J., Jeneson, J. A. L., Hilbers, P. A. J. & Riel, van, N. A. W., 2010, Proceedings of the 11th International Conference on Systems Biology (ICSB 2010), 11-14 October 2010, Edinburgh, United Kingdom. United Kingdom, Edinburgh, blz. P01.291-

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Inbred C57BL Mouse
Liver
Lipogenesis
Lipoproteins
Phenotype

In vivo data and computational modeling identify role of post translational modifications in regulating mitochondrial energy homeostasis in skeletal muscle

Schmitz, J. P. J., Jeneson, J. A. L., Nicolay, K., Hilbers, P. A. J. & Riel, van, N. A. W., 2010, Proceedings of the International Conference on Systems Biology (ICSB 2010), 10-15 October 2010, Edinburgh, United Kingdom.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Kinetic analysis of molecular mechanisms of HIF-1 signalling during acute hypoxia and reoxygenation

Tiemann, C. A., Hilbers, P. A. J. & Riel, van, N. A. W., 2010, Proceedings of the Keystone Symposia Hypoxia: Molecular Mechanisms of Oxygen Sensing and Response Pathways, 19-24 January 2010, Keystone, Colorado, U.S.A.. United States, Keystone

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Oxygen
Hydroxylation
Reaction Time
Motivation
Theoretical Models

Modeling glycolysis in skeletal muscle; exploring the control of calcium regulation

Schmitz, J. P. J., Groenendaal, W., Wessels, B., Jeneson, J. A. L., Nicolay, K., Hilbers, P. A. J., Prompers, J. J. & Riel, van, N. A. W., 2010, Proceedings of the NCSB 2010 Symposium, 21-22 October 2010, Soesterberg, The Netherlands.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Prediction of murine liver kinetics from plasma lipoprotein distributions

Tiemann, C. A., Berg, van den, S. A. A., Klinken, van, J. B., Dijk, van, K. W., Jeneson, J. A. L., Hilbers, P. A. J. & Riel, van, N. A. W., 2010, Proceedings of the Experimental Biology 2010, 24-28 April 2010, Anaheim, California, USA.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

lipoproteins
liver
kinetics
predictions
metabolism

Strategies for parameter uncertainty analysis

Vanlier, J., Tiemann, C. A., Jeneson, J. A. L., Hilbers, P. A. J. & Riel, van, N. A. W., 2010, Presentation at the NCSB symposium 2010, 21-22 October 2010, Soesterberg, The Netherlands.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Understanding the origin of mitochondrial (dys)function : a new systems biology based research strategy

Schmitz, J. P. J., Broek, van den, N. M. A., Ciapaite, J., Jonkers, R. A. M., Riel, van, N. A. W., Prompers, J. J., Nicolay, K., Hilbers, P. A. J. & Jeneson, J. A. L., 2010, Proceedings of the 14th Workshop of the International Study Group for Systems Biology (ISGSB 2010), 6-10 September 2010, Vladimir, Russia.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Why parameterization of signaling pathways is inherently difficult

Vanlier, J., Tiemann, C. A., Jeneson, J. A. L., Hilbers, P. A. J. & Riel, van, N. A. W., 2010, Proceedings of the 11th International Conference on Systems Biology (ICSB 2010) 11-14 October 2010, Edinburgh, United Kingdom.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

2009

A multi scale computational model of human skeletal muscle to quantify metabolite dynamics in individual fiber types from 31P MRS measurements

Schmitz, J. P. J., Riel, van, N. A. W., Jeneson, J. A. L., Nicolaij, K. & Hilbers, P. A. J., 2009, Proceedings of the 2nd Dutch BME Conference 2009 (BME 2009), 22-23 January 2009, Egmond aan Zee, The Netherlands.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Skeletal Muscle
Muscles
Adenosine Triphosphate
Magnetic Resonance Spectroscopy
Magnets