Projecten per jaar
Persoonlijk profiel
Research profile
Natal van Riel is Professor of Biomedical Systems Biology at the department of Biomedical Engineering at Eindhoven University of Technology, where he leads the Computational Biology group and the Systems Biology and Metabolic Diseases research program. He is also part-time Professor of Computational Modelling at Amsterdam University Medical Centers (location AMC, University of Amsterdam's Faculty of Medicine). His research focuses on modelling of metabolic networks and physiology, scientific machine learning for personalized models and human digital twins, and methods for analysing complex dynamical systems. He applies these approaches to cardiometabolic diseases, including obesity and type 2 diabetes. He actively collaborates with engineers, AI specialists, physiologists, clinicians, healthcare professionals, social scientists, and patients to translate data science and computational models into medical applications.
The role of bile acids in the complex interaction between gut microbiome and metabolic health is currently an important research focus in his group (e.g. in the RESOLVE project in collaboration with Amsterdam UMC). Within the NWO program ‘Complexity in Health and Nutrition’, Natal van Riel also focuses on modelling the digestion and metabolism of nutrients in the project ‘Metabolic adaptation, transitions and resilience in overweight individuals’. In cooperation with the Catharina hospital in Eindhoven he has developed the Metabolic Health Index (MHI) to quantify the benefit of bariatric surgery to resolve metabolic diseases (type 2 diabetes, dyslipidemia), which is a second important outcome of the surgical treatment in addition to weight reduction. He develops metabolic digital twins of human individuals to enable predictive, preventive, personalized, and participatory medicine. In the DiaGame project digital twins are developed to empower patients with diabetes in self-management of their disease.
Academic background
Natal van Riel studied Electrical Engineering at Eindhoven University of Technology (TU/e, The Netherlands) where he was trained in system identification and control engineering. After receiving his MSc degree in 1995, he started PhD research in the Biotechnology group of Unilever Research Vlaardingen (The Netherlands) under supervision of Prof. Theo Verrips, on integrating computational modelling and experiments to study cell metabolism. In 2000, he obtained his PhD from Utrecht University (The Netherlands). From 2000 to 2003, he worked in the department of Electrical Engineering of TU/e, investigating the application of system and control theory to understand biological processes. In 2003, he was appointed as Assistant Professor in the department of Biomedical Engineering at TU/e where he initiated Systems Biology research. This was expanded when he joined the group of Prof. Peter Hilbers in 2006, to lead the Computational Systems Biology research program, investigating complex, multi-factorial diseases. In 2014, Natal van Riel was appointed Associate Professor of Systems Biology and Metabolic Diseases. In that same year he was a visiting scholar of the department of Bioengineering at the University of California San Diego (UCSD) in the group of Prof. Bernhard Palsson. In 2015, he was appointed part-time Professor of Computational Modelling at the Academic Medical Center AMC (University of Amsterdam). In 2019, he was appointed full Professor of Biomedical Systems Biology at TU/e. In 2023 he became head of the Computational Biology group at TU/e.
Natal van Riel is chair of the Examination Committee of BmE and as such member of the general Examination Committee of the TU/e and member of the Quality Committee of the department. He is member of the Curriculum Committee of the department and coordinates the learning line on Biomedical Systems Modeling. He is also member of the Research Committee of the department and member of the Interdepartmental Committee (IFC) for Engineering.
Quote
Systems Biology has matured into a core methodology for integrative and quantitative life sciences. Our ambition is to translate its principles to biomedical research, clinical practice, and education - to better understand, cure, and ultimately prevent disease.
Onderwijs en Doceren
not shown in public profile
Expertise gerelateerd aan duurzame ontwikkelingsdoelstellingen van de VN
In 2015 stemden de VN-lidstaten in met 17 wereldwijde duurzame ontwikkelingsdoelstellingen (Sustainable Development Goals, SDG's) om armoede te beëindigen, de planeet te beschermen en voor iedereen welvaart te garanderen. Het werk van deze persoon draagt bij aan de volgende duurzame ontwikkelingsdoelstelling(en):
Externe posities
Professor Computational Modelling, Academic Medical Centre Amsterdam
nov. 2015 → …
Associate member of the Maastricht Centre for Systems Biology (MaCSBio), Maastricht University
2015 → …
Vingerafdruk
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
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Personalised dietary advice for human and planetary health
van Riel, N. A. W. (Project Manager) & Vacancy PD (Projectmedewerker)
1/04/24 → 31/03/28
Project: Third tier
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Gut-brain health effects of PREbiotics in older adults with suspected Cognitive Decline
van Riel, N. A. W. (Project Manager)
1/05/23 → 1/07/26
Project: Third tier
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ACACIA TKI2112P08
van Riel, N. A. W. (Project Manager) & van Mierlo, R. (Projectmedewerker)
1/05/21 → 30/04/26
Project: Third tier
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DiaGame: DiaGame: Serious and personalized game for self-management of diabetes
van Riel, N. A. W. (Project Manager), Van Gorp, P. (Project communicatie medewerker), de Vries, R. (Projectmedewerker) & Ferreira de Carvalho, D. (Project communicatie medewerker)
1/01/19 → 31/12/25
Project: Second tier
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NWO Building Blocks of Life 737.016.001 Yeast 3M
van Riel, N. A. W. (Project Manager), Lao Martil, D. (Projectmedewerker), Teusink, B. (Project communicatie medewerker), Wahl, S. A. (Project communicatie medewerker) & Schmitz, J. P. J. (Project communicatie medewerker)
1/01/18 → 31/12/22
Project: Onderzoek direct
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Physiology-informed regularisation enables training of universal differential equation systems for biological applications
de Rooij, M. (Corresponding author), Erdős, B., van Riel, N. A. W. & O'Donovan, S. D., jan. 2025, In: PLoS Computational Biology. 21, 1, 19 blz., e1012198.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand14 Downloads (Pure) -
An Interpretability-Driven Fuzzy Modeling Methodology for Personalized Meal Detection
De Carvalho, D. F., Kaymak, U., Van Gorp, P. & Van Riel, N., 5 aug. 2024, 2024 IEEE International Conference on Fuzzy Systems, FUZZ-IEEE 2024. Institute of Electrical and Electronics Engineers, 8 blz. 10611914Onderzoeksoutput: Hoofdstuk in Boek/Rapport/Congresprocedure › Conferentiebijdrage › Academic › peer review
Open AccessBestand5 Downloads (Pure) -
Does GLP-1 cause post-bariatric hypoglycemia: 'Computer says no'
Pasveer, Y. M., Aydin, Ö., Groen, A. K., Meijnikman, A. S., Nieuwdorp, M., Gerdes, V. E. A. & van Riel, N. A. W. (Corresponding author), dec. 2024, In: Computer Methods and Programs in Biomedicine. 257, 9 blz., 108424.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open AccessBestand11 Downloads (Pure) -
Ensemble Approaches for Enhancing Robustness and Reproducibility in RNA-Seq-Based Genome-Scale Metabolic Models
Theeuwes, B., Kroon, J. & Van Riel, N., 1 okt. 2024, (Geaccepteerd/In druk) 9th Conference on Constraint-Based Reconstruction and Analysis: COBRA 2024. American Institute of Chemical Engineers (AIChE)Onderzoeksoutput: Hoofdstuk in Boek/Rapport/Congresprocedure › Conferentiebijdrage › Academic › peer review
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Ethnic variations in metabolic syndrome components and their associations with the gut microbiota: the HELIUS study
Balvers, M., de Goffau, M., van Riel, N., van den Born, B.-J., Galenkamp, H., Zwinderman, K., Nieuwdorp, M. & Levin, E. (Corresponding author), 20 mrt. 2024, In: Genome Medicine. 16, 1, 41.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open Access6 Citaten (Scopus)
Datasets
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SugarVita: a Digital Board Game
van Riel, N. A. W. (Ontwerper), Eindhoven University of Technology, 30 apr. 2024
https://clinicaltrials.gov/study/NCT06392178?term=NCT06392178
Dataset
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DiaGame: Serious and personalized game for selfmanagement of diabetes
van Riel, N. A. W. (Ontwerper), Eindhoven University of Technology, 13 nov. 2023
https://www.onderzoekmetmensen.nl/en/trial/25562
Dataset
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Model-based analysis of postprandial glycemic response dynamics for different types of food
Rozendaal, Y. J. W. (Ontwerper), Hilbers, P. (Ontwerper) & van Riel, N. (Ontwerper), Zenodo, 18 mrt. 2018
DOI: 10.1016/j.yclnex.2018.01.003, https://zenodo.org/record/4032428
Dataset
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Computational modelling of energy balance in individuals with Metabolic Syndrome
Rozendaal, Y. J. W. (Ontwerper), Wang, Y. (Bijdrager), Hilbers, P. A. J. (Ontwerper) & van Riel, N. A. W. (Bijdrager), Figshare, 26 feb. 2019
DOI: 10.6084/m9.figshare.c.4416167, https://springernature.figshare.com/collections/Computational_modelling_of_energy_balance_in_individuals_with_Metabolic_Syndrome/4416167 en nog één link, https://springernature.figshare.com/collections/Computational_modelling_of_energy_balance_in_individuals_with_Metabolic_Syndrome/4416167/1 (minder tonen)
Dataset
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Database for "The impact of amino acids on postprandial glucose and insulin kinetics in humans: a quantitative overview"
van Sloun, B. (Ontwerper), Goossens, G. H. (Ontwerper), Erdős, B. (Ontwerper), Lenz, M. (Ontwerper), van Riel, N. A. W. (Ontwerper), Arts, I. C. W. (Ontwerper) & Wauters, F. (Bijdrager), DataverseNL, 21 okt. 2020
DOI: 10.34894/rnzi0a
Dataset
Prijzen
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AMC Principal Investigator
van Riel, N. (Ontvanger), 1 mei 2016
Prijs: Anders › Werk, activiteit of publicatie gerelateerde prijzen (lifetime, best paper, poster etc.) › Wetenschappelijk
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COST Action BM1402: Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE)
van Riel, N. (Ontvanger), 1 dec. 2014
Prijs: Anders › Discipline gerelateerd › Wetenschappelijk
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Koninklijke Onderscheiding; Lid in de Orde van Oranje-Nassau/ Recipient of Dutch Royal Order of Chivalry, Order of Orange-Nassau
van Riel, N. (Ontvanger), 27 mrt. 2014
Prijs: Anders › Werk, activiteit of publicatie gerelateerde prijzen (lifetime, best paper, poster etc.) › Wetenschappelijk
Activiteiten
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Personalized modelling of bile acid metabolism: predicting metabolic effects of bariatric surgery
van Riel, N. (Spreker)
6 jul. 2018Activiteit: Types gesprekken of presentaties › Genodigd spreker › Wetenschappelijk
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A physiology based glucose-insulin-GLP-1 model: explaining changes observed after Roux-en-Y gastric bypass
Thijssen, L. C. P. (Spreker) & van Riel, N. (Deelnemer)
15 mei 2018Activiteit: Types gesprekken of presentaties › Aangemelde presentatie › Wetenschappelijk
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4th Dutch Bioinformatics & Systems Biology Conference
van Riel, N. (Organisator)
15 mei 2018 → 16 mei 2018Activiteit: Types deelname aan of organisatie van een evenement › Congres › Wetenschappelijk
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Systems Medicine of Metabolic Syndrome; metabolic benefits of bariatric surgery
van Riel, N. (Spreker)
2 mrt. 2018Activiteit: Types gesprekken of presentaties › Genodigd spreker › Wetenschappelijk
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Modeling of postprandial metabolic dynamics in human individuals
van Riel, N. (Organisator)
22 jan. 2018Activiteit: Types deelname aan of organisatie van een evenement › Workshop, seminar, cursus of expositie › Wetenschappelijk
Cursussen
Knipsels
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Data on Proinsulin Reported by Bart van Sloun and Colleagues (Quantifying postprandial glucose responses using a hybrid modeling approach: Combining mechanistic and data-driven models in The Maastricht Study)
van Riel, N. A. W. & O'Donovan, S.
10/08/23
1 item van Media-aandacht
Pers / media: Vakinhoudelijk commentaar
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New computational tool predicts progression of metabolic syndrome in mice
van Riel, N. & Rozendaal, Y. J. W.
7/06/18
1 Mediabijdrage
Pers / media: Onderzoek
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PANINI Public Engagement Event
Cabbia, A. & van Riel, N. A. W.
29/01/17
1 Mediabijdrage
Pers / media: PR activiteiten
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Scriptie
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Algorithms for estimation of model errors and uncertainties arising in black box system identification
van Riel, N. A. W. (Auteur), van den Bosch, P. P. J. (Afstudeerdocent 1), 31 okt. 1995Scriptie/Masterproef: Master
Bestand