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Persoonlijk profiel

Quote

"Addressing biomedical challenges via bottom-up chemical approaches provides a unique training ground and offers fantastic opportunities for interdisciplinary science."

Research profile

Luc Brunsveld is professor of Chemical Biology at the department of Biomedical Engineering. His research interests are focused on chemical biology approaches studying protein-protein interactions, particularly drug discovery and supramolecular signalling systems. Combining synthetic and supramolecular chemistry with chemical biology allows exact molecular modulation of biological systems. Since 2011 the Chemical Biology group has been embedded in the interdepartmental Institute of Complex Molecular Systems (ICMS) and the NWO Gravity Research Center for Functional Molecular Systems. The group has developed a strong expertise in organic synthesis, peptide and protein chemistry, chemical biology, and supramolecular chemistry, enabling the development of new molecules and materials to study, engineer, and modulate protein-protein interactions. The realization of a synthetic cell and novel drugs via the modulation of protein-protein interactions are high on the group's wish list.

Academic background

Luc Brunsveld studied Chemistry and Chemical Engineering at the Technische Universiteit Eindhoven (TU/e, The Netherlands) and Osaka University (Japan). After obtaining his Master's degree in 1997 he performed his PhD research at TU/e and the University of Illinois at Urbana-Champaign (USA) in the field of supramolecular chemistry, under supervision of Prof. E.W. (Bert) Meijer. In 2001, he obtained his doctorate cum laude. From 2001-2003, he was a postdoctoral fellow with Prof. Herbert Waldmann at the Max-Planck Institute of Molecular Physiology (MPI, Dortmund, Germany) working on protein semi-synthesis. From 2003-2004, he was group leader in medicinal chemistry at Organon (Oss, the Netherlands, now Merck). In 2005, he started a research group at MPI in Dortmund working on supramolecular chemical biology, and subsequently also became group leader at the Chemical Genomics Centre of the Max Planck Society, working on Nuclear Receptor protein interactions. In 2008, he moved to TU/e where he was appointed Full Professor of Chemical Biology in the Department of Biomedical Engineering. Brunsveld has received numerous appealing grants, among which ERC Starting and Proof of Concept grants (2008 and 2010, respectively) and the NWO Vici grant (2015). He was awarded the NVBMB Award of the Dutch Society for Biochemistry and Molecular Biology in 2010 and the Gold Medal of the Royal Netherlands Chemical Society KNCV in 2013.

Vingerafdruk Duik in de onderzoeksthema's waar Luc Brunsveld actief is. Deze onderwerplabels komen voort uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.

  • 16 Vergelijkbare profielen
Proteins Chemische stoffen
14-3-3 Proteins Medicijnen en Levenswetenschappen
Molecules Chemische stoffen
Peptides Chemische stoffen
Ligands Chemische stoffen
Scaffolds Chemische stoffen
Estrogen Receptors Medicijnen en Levenswetenschappen
Self assembly Chemische stoffen

Netwerk Recente externe samenwerking op landenniveau. Duik in de details door op de stippen te klikken.

Onderzoeksoutput 1997 2020

7 Downloads (Pure)

Fluorene benzothiadiazole co-oligomer based aqueous self-assembled nanoparticles

Schill, J., Ferrazzano, L., Tolomelli, A., Schenning, A. P. H. J. & Brunsveld, L., 2 jan 2020, In : RSC Advances. 10, 1, blz. 444-450 7 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Oligomers
Nanoparticles
Energy transfer
Self assembly
Tuning
13 Downloads (Pure)

Ligand-based design of allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists

Meijer, F. A., Doveston, R. G., de Vries, R. M. J. M., Vos, G. M., Vos, A. A. A., Leysen, S., Scheepstra, M., Ottmann, C., Milroy, L-G. & Brunsveld, L., 9 jan 2020, In : Journal of Medicinal Chemistry. 63, 1, blz. 241-259 19 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Retinoic Acid Receptors
Isoxazoles
Cytoplasmic and Nuclear Receptors
Ligands
Interleukin-17
5 Downloads (Pure)

Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome

Rosier, B., Markvoort, B., Gumi Audenis, B., Roodhuizen, J., den Hamer, A., Brunsveld, L. & de Greef, T. F. A., 6 jan 2020, In : Nature Catalysis. 12 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Apoptosomes
Caspase 9
DNA
Protein Engineering
Multiprotein Complexes
5 Citaties (Scopus)
132 Downloads (Pure)

Allosteric small molecule modulators of nuclear receptors

Meijer, F. A., Leijten-van de Gevel, I. A., de Vries, R. M. J. M. & Brunsveld, L., 5 apr 2019, In : Molecular and Cellular Endocrinology. 485, blz. 20-34 15 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

Open Access
Bestand
Cytoplasmic and Nuclear Receptors
Allosteric Site
Ligands
Drug Discovery
Pathology
4 Downloads (Pure)

A study on the effect of synthetic α-to-β3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins

Andrei, S. A., Thijssen, V., Brunsveld, L., Ottmann, C. & Milroy, L-G., 5 dec 2019, In : Chemical Communications. 55, 98, blz. 14809-14812 4 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
14-3-3 Proteins
Phosphopeptides
Amino acids
Substitution reactions
Proteins

Prijzen

Golden Medal Royal Dutch Chemical Society 2012

Luc Brunsveld (Ontvanger), 2012

Prijs: AndersWerk, activiteit of publicatie gerelateerde prijzen (lifetime, best paper, poster etc.)Wetenschappelijk

NWO Vici Award : Synthetic Supramolecular Signalling Systems

L. Brunsveld (Ontvanger), 2014

Prijs: NWOViciWetenschappelijk

Biomolecules

Research Center for Functional Molecular Systems

E.W. Meijer (Ontvanger), J.C.M. van Hest (Ontvanger), L. Brunsveld (Ontvanger), R.A.J. Janssen (Ontvanger) & R.P. Sijbesma (Ontvanger), 2013

Prijs: NWOZwaartekrachtWetenschappelijk

selection procedure
Ministry of Education
Netherlands
funding
science

Supramolecular Chemical Biology Modulation of Protein-Protein Interactions

L. Brunsveld (Ontvanger), 2007

Prijs: ERCStartingWetenschappelijk

Modulation
Proteins
Supramolecular chemistry
Scaffolds
Dimerization

Targeting the biological imaging market with multifunctional fluorescent nanoparticles

L. Brunsveld (Ontvanger), 2011

Prijs: ERCProof of conceptWetenschappelijk

Nanoparticles
Imaging techniques
Molecular imaging
Industry
Acoustic waves

Cursussen

Biological physics

1/09/12 → …

Cursus

Chemische biologie

1/09/1331/08/20

Cursus

Farmacologie

1/09/13 → …

Cursus

iGEM project

1/09/14 → …

Cursus

Scriptie

ABCB1 variants in association with clopidogrel response

Auteur: de Kock, R., 29 sep 2016

Begeleider: Brunsveld, L. (Afstudeerdocent 1), Hilbers, P. (Afstudeerdocent 2), Scharnhorst, V. (Afstudeerdocent 2) & Deiman, B. (Externe persoon) (Externe coach)

Scriptie/masterproef: Master

Alternative modulation of nuclear receptor function

Auteur: Hoek, N., 31 mrt 2014

Begeleider: Milroy, L. (Afstudeerdocent 1), Scheepstra, M. (Afstudeerdocent 2) & Brunsveld, L. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Characterization of the interaction between 14-3-3 and the R-domain of CFTR

Auteur: van de Sande, M., 29 mrt 2018

Begeleider: Stevers, L. (Afstudeerdocent 1) & Brunsveld, L. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Characterization of the interaction of 14-3-3 proteins and estrogen receptor alpha as a potential drug target

Auteur: den Hamer, A., 30 nov 2013

Begeleider: de Vries - van Leeuwen, I. (Externe coach), Tharun, I. (Afstudeerdocent 1), Ottmann, C. (Afstudeerdocent 2) & Brunsveld, L. (Afstudeerdocent 2)

Scriptie/masterproef: Master

Chemical biological evaluation of the estrogen receptor F domain on folding and activity

Auteur: Kurdi, M., 31 jan 2009

Begeleider: Phan, T. (Externe persoon) (Afstudeerdocent 1) & Brunsveld, L. (Afstudeerdocent 2)

Scriptie/masterproef: Master