Onderzoeksoutput per jaar
Persoonlijk profiel
Quote
'The ‘smartest’ biomaterials are the natural tissues in our bodies. If only we could unlock their secrets and bioengineer smart biomimetic biomaterials that help our tissues to heal, responding to their cues.'
Research profile
Keita Ito chairs the research group Orthopaedic Biomechanics, where engineering and biology are combined to expand our understanding of the biomechanical function of musculoskeletal tissues as well as their adaptive developmental and physiological nature. This knowledge is then applied to explore and develop regenerative treatment strategies. Currently the research focuses on four musculoskeletal tissues: bone; articular cartilage; intervertebral disc; and tendons/ligaments.
He personally leads the research effort on the topic of the intervertebral discs. Degenerative disc disease is one of the most prevalent causes of back/neck pain that often leads to disability for individuals of working age. The goal of the research is to understand the basic mechanisms of disc degeneration and to develop long-term functional treatments for this condition.
The strategy focuses on: exploring deficient nutrition, loss of high tissue tonicity and mechanical loading as mechanotransduction mechanisms of cellular stimulated degeneration; how these degenerative changes may cause failure of disc function; and then using this understanding to explore tissue engineering approaches towards disc regeneration. The approach is to combine numerical simulations with tissue explant ex vivo experiments in bioreactors where the physical environment can be controlled.
Academic background
Keita Ito studied Mechanical Engineering at the Massachusetts Institute of Technology (MIT, Cambridge, MA, USA) where he received his MSc degree in 1987. In 1994 he obtained his ScD in Medical Engineering and Medical Physics from MIT. The next year he graduated as MD from Harvard Medical School (Boston, MA, USA). From 1995-1996 he was a post-doctoral Research Fellow at the AO Research Institute (Davos, Switzerland), to become group head of the Cartilage Biomechanics Group from 1996-2003 and Vice Director and leader of the Mechanobiology Program from 2003-2007. From 1997-1998 he was a Research Fellow at the department of Orthopaedic Surgery at Inselspital University Hospital Bern (Switzerland). In 2002 and 2003 he was Visiting Scientist at the department of Biomedical Engineering of Eindhoven University of Technology (TU/e, The Netherlands), where he was appointed Professor of Mechano-biology and Musculoskeletal Tissue Differentiation in 2004. In 2007 he became Full Professor of Orthopaedic Biomechanics at TU/e. In 2013 Ito was appointed as Professor of Mechanobiology in Orthopaedic Regenerative Medicine at the University Medical Center Utrecht (The Netherlands), in collaboration with TU/e.
Affiliated with
- Institute for Complex Molecular Systems, TU/e
- Regenerative Medicine Across Borders
- Materials Driven Regeneration, NWO Gravitation Program
Partners in (semi-)industry
- DSM Biomedical BV, Geleen, NL
- AO Foundation, Davos, CH
- Fujifilm, Tilburg, NL
Vingerafdruk Verdiep u in de onderzoeksgebieden waarop Keita Ito actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 29 Soortgelijke profielen
Netwerk
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Onderzoeksoutput
Alterations to the subchondral bone architecture during osteoarthritis : bone adaptation versus endochondral bone formation
Cox, L. G. E., Donkelaar, van, C. C., Rietbergen, van, B., Emans, P. J. & Ito, K., 2013, In : Osteoarthritis and Cartilage. 21, 2, blz. 331-338 8 blz.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
27
Citaten
(Scopus)
5
Downloads
(Pure)
Long-term culture of bovine nucleus pulposus explants in a native environment
Dijk, van, B. G. M., Potier, E. & Ito, K., 2013, In : The Spine Journal. 13, 4, blz. 454-463Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
23
Citaten
(Scopus)
1
Downloads
(Pure)
Bone remodelling in humans is load-driven but not lazy
Christen, P., Ito, K., Ellouz, R., Boutroy, S., Sornay-Rendu, E., Chapurlat, R. & Rietbergen, van, B., 2014, In : Nature Communications. 5, blz. 4855-1/5 5 blz.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open Access
Bestand
81
Citaten
(Scopus)
146
Downloads
(Pure)
Soluble and pelletable factors in porcine, canine and human notochordal cell-conditioned medium: implications for IVD regeneration
Bach, F. C., de Vries, S. A. H., Riemers, F. M., Boere, J., van Heel, F. W. M., van Doeselaar, M., Goerdayal, S. S., Nikkels, P. G. J., Benz, K., Creemers, L. B., Altelaar, A. F. M., Meij, B. P., Ito, K. & Tryfonidou, M. A., 2016, In : European Cells and Materials. 32, blz. 163-180Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Open Access
Bestand
10
Citaten
(Scopus)
102
Downloads
(Pure)
Accuracy of beam theory for estimating bone tissue modulus and yield stress from 3-point bending tests on rat femora
Arias-Moreno, A. J., Ito, K. & van Rietbergen, B., 5 mrt 2020, In : Journal of Biomechanics. 101, 8 blz., 109654.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
Datasets
Database of femur samples
Hazrati Marangalou, J. (Ontwerper), Technische Universiteit Eindhoven, 2013
DOI: https://doi.org/10.4121/uuid:4ae59365-92f0-480b-a899-ade34bc84a00
Dataset
Cursussen
Knipsels
EUR 350,000 for Eindhoven University of Technology Pilot With Gel That Restores Spinal Disc Degeneration
2/04/20
1 item van Media-aandacht
Pers / media: Vakinhoudelijk commentaar
Professor Maarten Merkx new Dean of the Department of Biomedical Engineering at TU/e
Frank P.T. Baaijens, Peter A.J. Hilbers, Maarten Merkx, Keita Ito & Josien P.W. Pluim
21/10/19
1 item van Media-aandacht
Pers / media: Vakinhoudelijk commentaar
WIPO PUBLISHES PATENT OF TECHNISCHE UNIVERSITEIT EINDHOVEN FOR "NOTOCHORDAL CELL MATRIX AS A BIOACTIVE LUBRICANT FOR THE OSTEOARTHRITIC JOINT" (DUTCH INVENTORS)
12/08/19
1 item van Media-aandacht
Pers / media: Vakinhoudelijk commentaar
TU/e spin-off is working on a biomaterial that will help to treat spinal disc degeneration
13/06/19
1 item van Media-aandacht
Pers / media: Vakinhoudelijk commentaar
Researchers developing biomaterial to treat spinal disc degeneration
13/06/19
1 item van Media-aandacht
Pers / media: Vakinhoudelijk commentaar
Scriptie
3D human osteoblast - osteoclast in vitro co-culture
Auteur: Remmers, S. & Mayer, D., 2019Begeleider: Remmers, S. (Afstudeerdocent 1), Melke, J. (Afstudeerdocent 1), Hofmann, S. (Afstudeerdocent 1), Ito, K. (Afstudeerdocent 1) & Teuschl, A. (Externe persoon) (Afstudeerdocent 2)
Scriptie/masterproef: Master
3D laxity assessment in ACL-patients
Auteur: Kruis, N., 1 jan 2016Begeleider: Ito, K. (Afstudeerdocent 1), van Rietbergen, B. (Afstudeerdocent 2), Verdonschot, N. J. (Externe persoon) (Externe coach) & Sprengers, A. (Afstudeerdocent 1)
Scriptie/masterproef: Master
3D quantification of lumbar spinal dynamics at the time of surgery
Auteur: Vugts, C., 31 dec 2008Begeleider: Ito, K. (Afstudeerdocent 1)
Scriptie/masterproef: Master
A method for the determination of the human muscular PCSA based on diffusion tensor imaging
Auteur: Kierkels, T., 31 aug 2015Begeleider: Ito, K. (Afstudeerdocent 1), van Rietbergen, B. (Afstudeerdocent 2), Meijer, K. (Externe coach), Drost, M. (Externe coach) & Oomen, P. (Externe coach)
Scriptie/masterproef: Master
A microtissue platform as screening method for ACL reconstructive surgery outcome: towards personalized rehabilitation
Auteur: Kimenai, J., 30 jan 2020Begeleider: Ito, K. (Afstudeerdocent 1), van der Steen, M. (Externe persoon) (Externe coach) & Foolen, J. (Afstudeerdocent 2)
Scriptie/masterproef: Master