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Persoonlijk profiel

Quote

Breaking boundaries and bridging disciplines is the key challenge to revolutionize our understanding of immunoengineering and to increase the impact on healthcare.

Research profile

Dr. Jurjen Tel leads the Immunoengineering research group at the department of Biomedical Engineering of Eindhoven University of Technology (TU/e). He strives to develop and apply innovative tools to study the immune system and to create or improve therapies by enhancing or modulating immune responses. Central to his research is a systems immunology approach, taking into account that successful immunotherapy has to deal with a wide range cell types, specialized subtypes and signaling molecules. To study cellular heterogeneity in conjunction with signals from the microenvironment, and thus be able to investigate regulatory strategies of cell populations, Tel's group is developing an innovative 'single cell technology toolbox'. This will enable the compartmentalization of single cells or small groups of cells in chambers or droplets, allowing for the design of 'minimal environments' where most of the external factors influencing cellular behavior are excluded. Similarly, complex artificial microenvironments can be designed to assess the behavior of single cells in response to e.g. soluble messengers or potential interaction partners. By thus probing cellular heterogeneity and decoding immune interactions in great detail, Tel hopes to revolutionize the fields of immunology and cellular immunotherapy. His research currently revolves around human dendritic cells (DCs) that are key regulators in pathogen sensing. He also cooperates in projects regarding macrophages, NK cells, circulating tumor cells, and multifunctional killer T cells and their role in regenerative medicine, cellular anti-cancer vaccines and patient stratification. Finally, together with the group of Prof. Jan van Hest, he aims to boost the field of artificial immunotherapy. 

Academic background

Jurjen Tel obtained a Bachelor's degree in Applied Sciences in the field of Medical Microbiology at the NHL University of Applied Sciences (Leeuwarden, The Netherlands) in 2005. He continued his studies at the University of Groningen (RUG, The Netherlands) where he obtained his Master of Science degree in Medical Biology in 2007. He continued with PhD research in the department of Tumor Immunology of prof. Carl Figdor (Radboudumc Nijmegen, The Netherlands) under supervision of Prof. Jolanda de Vries. In 2013, he graduated cum laude with his thesis 'Plasmacytoid Dendritic Cells & Immunotherapy of Cancer'. Based on his findings he applied for a NWO-Veni grant, hypothesizing that there is a deeper layer of functional heterogeneity in the plasmacytoid dendritic cell population. The grant, awarded in 2013, allowed him to start a collaboration with Prof. Wilhelm Huck (Dept. Physical Organic Chemistry at Radboud University Nijmegen (The Netherlands) as a postdoctoral fellow, to exploit droplet-based microfluidics to probe this observed cellular heterogeneity. In 2016, he was appointed assistant professor at Eindhoven University of Technology to establish a new research group on Immunoengineering.

Vingerafdruk Duik in de onderzoeksthema's waar Jurjen Tel actief is. Deze onderwerplabels komen voort uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.

Dendritic Cells Medicijnen en Levenswetenschappen
T-Lymphocytes Medicijnen en Levenswetenschappen
Myeloid Cells Medicijnen en Levenswetenschappen
T-cells Chemische stoffen
Immunotherapy Medicijnen en Levenswetenschappen
Cross-Priming Medicijnen en Levenswetenschappen
Antigens Medicijnen en Levenswetenschappen
Microfluidics Medicijnen en Levenswetenschappen

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Onderzoeksoutput 2010 2019

  • 1807 Citaten
  • 47 Tijdschriftartikel
  • 2 Artikel recenseren
  • 1 Dissertatie 4 (Onderzoek NIET TU/e / Promotie NIET TU/e)
2 Citaties (Scopus)
20 Downloads (Pure)

A pipette-tip based method for seeding cells to droplet microfluidic platforms

Sinha, N., Subedi, N., Wimmers, F., Soennichsen, M. & Tel, J., 11 feb 2019, In : Journal of Visualized Experiments (JoVE). 144, 10 blz., e57848.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Cloud seeding
Microfluidics
Encapsulation
Poisson distribution
Poisson Distribution
5 Citaties (Scopus)
55 Downloads (Pure)

Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine

Wauters, A. C., Pijpers, I. A. B., Mason, A. F., Williams, D. S., Tel, J., Abdelmohsen, L. K. E. A. & van Hest, J. C. M., 14 jan 2019, In : Biomacromolecules. 20, 1, blz. 177-183 7 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Medical nanotechnology
Nanotubes
Polyethylene glycols
Particle interactions
Nanostructures
24 Citaties (Scopus)
1 Downloads (Pure)

Customizing poly(lactic-co-glycolic acid) particles for biomedical applications

Swider, E., Koshkina, O., Tel, J., Cruz, L. J., de Vries, I. J. M. & Srinivas, M., 1 jan 2018, In : Acta Biomaterialia. 73, June 2018, blz. 38-51

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Acids
Biodegradability
Biocompatibility
Nanoparticles
Research Personnel
8 Citaties (Scopus)
16 Downloads (Pure)

Injectable biomimetic hydrogels as tools for efficient T Cell expansion and delivery

Weiden, J., Voerman, D., Dölen, Y., Das, R. K., van Duffelen, A., Hammink, R., Eggermont, L. J., Rowan, A. E., Tel, J. & Figdor, C. G., 28 nov 2018, In : Frontiers in Immunology. 9, 15 blz., 02798.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Biomimetics
Hydrogels
T-Lymphocytes
Injections
Azides
2 Citaties (Scopus)
116 Downloads (Pure)

Integrating immunology and microfluidics for single immune cell analysis

Sinha, N., Subedi, N. & Tel, J., 16 okt 2018, In : Frontiers in Immunology. 9, 16 blz., 2373.

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

Open Access
Bestand
Single-Cell Analysis
Microfluidics
Allergy and Immunology
Immune System
Point-of-Care Systems

Prijzen

Decoding cellular interactions

J. Tel (Ontvanger), 2018

Prijs: ERCStartingWetenschappelijk

Dendritic Cells
Immune System
Immune System Diseases
Cell Communication
Interferons

Cursussen

Host response to biomaterials

1/09/1631/08/20

Cursus

Immunologie & infectie

1/09/13 → …

Cursus

OGO Oncologie

1/09/13 → …

Cursus

Pers/media

Random fraction of specialized immune cells leads the charge in battling invaders

J. Tel

29/08/18

1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Impacten

Immune circuit construction using multi-layer microfluidic designs

Jurjen Tel (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager), Moniek Looijenga (Content manager)

Impact: Research Topic/Theme (at group level)

Single-cell analysis of immune cells using droplet-based microfluidics

Jurjen Tel (Content manager), Lieke van Gorp (Content manager), Amy Broeders (Content manager), Moniek Looijenga (Content manager)

Impact: Research Topic/Theme (at group level)

Scriptie

Probing macrophage plasticity and heterogeneity using microfluidic single-cell encapsulation and multicolor flow cytometry

Auteur: Tiemeijer, B., 25 apr 2019

Begeleider: Tel, J. (Afstudeerdocent 1), Smits, A. (Afstudeerdocent 2) & Subedi, N. (Afstudeerdocent 2)

Scriptie/masterproef: Master

The effect of acidosis on osteoclastic bone resorption in 3D in vitro

Auteur: Sleddens, M., 31 aug 2017

Begeleider: Ito, K. (Afstudeerdocent 1), Hofmann Boss, S. (Afstudeerdocent 2), Tel, J. (Afstudeerdocent 2) & Remmers, S. (Afstudeerdocent 2)

Scriptie/masterproef: Master

The Warburg effect: a tissue scale phenomenon

Auteur: Haakma, J., 20 jun 2019

Begeleider: Hilbers, P. (Afstudeerdocent 1), van Riel, N. (Afstudeerdocent 2) & Tel, J. (Afstudeerdocent 2)

Scriptie/masterproef: Master