The recent advancement of biomaterials and 3D additive manufacturing (AM) or 3D printer brings the possibility to construct a regenerative scaffold with a complex structure. To imitate a tubular structure of soft tissues, e.g., a coronary vessel, the micrometre-scale resolution of a 3D printer is crucial. For this reason, melt electrowriting (MEW) will be more explored to construct microfibers through the electrohydrodynamic process. This technique is able to create a micrometric mesh layer by layer, thus making it attractive for small-diameter vascular grafts, especially, coronary vessels. Therefore, the current research is exploring the application of MEW in small-diameter vascular grafts by utilizing its potential to create complex geometry and study the impact of geometry design on cellular response, i.e. vessel regeneration and biocalcification.

Jirawat Iamsamang is a PhD candidate in Biomedical engineering at TU/e. He graduated with both bachelor's and master’s degrees in biomedical engineering from Mahidol University (Thailand). Throughout his previous works, he focused on electronics and computational science to address problems in various topics: electrocardiogram analysis for arrhythmia detection, biomedical instrumentation, and lastly the computational design of a 3D printed bone scaffold by implicit modelling. In 2022, he joined the Biomaterials design and processing group as a PhD student under Asst.dr.ir. Miguel Dias Castilho to explore the application of melt electrowriting and computational design for creating bioresorable vascular scaffold. Currently, he focuses on the challenges of melt electrowritten scaffold and mechanical cues including cyclic stretch and wall shear stress to guided anisotropic tissue formation while withstand the mechanical failture from cyclic fatigue and fiber delamination.