• 15375 Citaties
1992 …2020

Onderzoeksresultaten per jaar

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Persoonlijk profiel


"Creating molecular assemblies with life-like properties is not only of crucial importance to better understand the living cell, but also leads to the design of the next generation adaptive materials."

Research profile

Jan van Hest works at the cutting edge of (polymer) chemistry and biomedicine. He focuses on the design and synthesis of bio-inspired peptide-based materials and the development of conjugation methods for the preparation of biohybrid systems. The objective of his research is to construct smart compartments with life-like features, which develops along two main lines of research: nanomedicine and artificial cells and organelles.

The nanomedicine research line in particular concerns medicine transport systems and synthetic vaccines. Using a combination of techniques from polymer science to protein engineering, well-defined carriers and scaffolds are developed for application in e.g. cancer treatment, immunology and ophthalmology.

Van Hest is also active in the field of artificial and hybrid cells where he designs and constructs adaptive nano- and microcompartments that simulate living cells. His artificial nanoreactors can be incorporated as artificial organelles in living cells to complement or affect cellular processes.

Academic background

Jan van Hest obtained his PhD in macro-organic chemistry with professor Bert Meijer from Eindhoven University of Technology (TU/e) in 1996. He then worked as a postdoc researcher on protein engineering with professor David A. Tirrell at the University of Massachusetts. In 1997 van Hest started working at DSM (Geleen), first as a researcher and later as group head in the development of new material concepts. In 2000 Van Hest was appointed as full professor at Radboud University Nijmegen. As of September 2016 he holds the chair of Bio-organic Chemistry at TU/e. Over 30 PhD candidates have gained their doctorates under his supervision. He has published over 300 scientific articles (H-index 57) and is (co-)inventor of 17 patents and patent applications. Jan van Hest is also the joint founder of the start-ups Encapson, FutureChemistry, Noviosense and Noviotech.

Affiliated with

  • Gravitation program Functional Molecular Systems
  • ICMS
  • PTN (postgraduate education polymer technology the Netherlands)

Partners in (semi-)industry

  • Zoetis
  • GSK

Vingerafdruk Verdiep u in de onderzoeksgebieden waarop Jan C.M. Hest, van actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.

  • 17 Soortgelijke profielen

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A virus-based biocatalyst

Carette, N., Engelkamp, H., Akpa, E., Pierre, S. J., Cameron, N. R., Christianen, P. C. M., Maan, J. C., Thies, J. C., Weberskirch, R., Rowan, A. E., Nolte, R. J. M., Michon, T. & van Hest, J. C. M., apr 2007, In : Nature Nanotechnology. 2, 4, blz. 226-229 4 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • 97 Citaten (Scopus)
    2 Downloads (Pure)

    Autonomous movement of platinum-loaded stomatocytes

    Wilson, D. A., Nolte, R. J. M. & van Hest, J. C. M., apr 2012, In : Nature Chemistry. 4, 4, blz. 268-274 7 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • 322 Citaten (Scopus)
    4 Downloads (Pure)

    Cascade reactions in multicompartmentalized polymersomes

    Peters, R. J. R. W., Marguet, M., Marais, S., Fraaije, M. W., van Hest, J. C. M. & Lecommandoux, S., 3 jan 2014, In : Angewandte Chemie - International Edition. 53, 1, blz. 146-150 5 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • 252 Citaten (Scopus)
    2 Downloads (Pure)

    Biomimicry of Cellular Motility and Communication Based on Synthetic Soft-Architectures

    Wang, L., Song, S., van Hest, J., Abdelmohsen, L. K. E. A., Huang, X. & Sánchez, S., 6 apr 2020, In : Small.

    Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

  • CD44-targeted vesicles encapsulating granzyme B as artificial killer cells for potent inhibition of human multiple myeloma in mice

    Zhong, Y., Meng, F., Zhang, W., Li, B., van Hest, J. C. M. & Zhong, Z., 10 apr 2020, In : Journal of Controlled Release. 320, blz. 421-430 10 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • 2 Citaten (Scopus)


    Artificial endosymbiosis

    J.C.M. van Hest (Ontvanger), 2015

    Prijs: ERCAdvancedWetenschappelijk

  • Research Center for Functional Molecular Systems

    E.W. Meijer (Ontvanger), J.C.M. van Hest (Ontvanger), L. Brunsveld (Ontvanger), R.A.J. Janssen (Ontvanger) & R.P. Sijbesma (Ontvanger), 2013

    Prijs: NWOZwaartekrachtWetenschappelijk

  • Scriptie

    De synthese van amfifiele polystyreen-ionene blockcopolymeren en de toepassing als polymere cokatalysator voor de katalytische oxidatie van 1-dodecaanthiol

    Auteur: van Hest, J., 31 dec 1991

    Begeleider: German, A. (Afstudeerdocent 1) & Schipper, F. (Begeleider)

    Scriptie/masterproef: Master

    Development of reduction responsive polymersomes for controlled drug delivery

    Auteur: Stam, R., 13 nov 2018

    Begeleider: Pijpers, I. (Afstudeerdocent 1), van Hest, J. (Afstudeerdocent 2), Brunsveld, L. (Afstudeerdocent 2) & Abdelmohsen, L. (Afstudeerdocent 2)

    Scriptie/masterproef: Master