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Persoonlijk profiel

Quote

"Creating molecular assemblies with life-like properties is not only of crucial importance to better understand the living cell, but also leads to the design of the next generation adaptive materials."

Research profile

Jan van Hest works at the cutting edge of (polymer) chemistry and biomedicine. He focuses on the design and synthesis of bio-inspired peptide-based materials and the development of conjugation methods for the preparation of biohybrid systems. The objective of his research is to construct smart compartments with life-like features, which develops along two main lines of research: nanomedicine and artificial cells and organelles.

The nanomedicine research line in particular concerns medicine transport systems and synthetic vaccines. Using a combination of techniques from polymer science to protein engineering, well-defined carriers and scaffolds are developed for application in e.g. cancer treatment, immunology and ophthalmology.

Van Hest is also active in the field of artificial and hybrid cells where he designs and constructs adaptive nano- and microcompartments that simulate living cells. His artificial nanoreactors can be incorporated as artificial organelles in living cells to complement or affect cellular processes.

Academic background

Jan van Hest obtained his PhD in macro-organic chemistry with professor Bert Meijer from Eindhoven University of Technology (TU/e) in 1996. He then worked as a postdoc researcher on protein engineering with professor David A. Tirrell at the University of Massachusetts. In 1997 van Hest started working at DSM (Geleen), first as a researcher and later as group head in the development of new material concepts. In 2000 Van Hest was appointed as full professor at Radboud University Nijmegen. As of September 2016 he holds the chair of Bio-organic Chemistry at TU/e. Over 30 PhD candidates have gained their doctorates under his supervision. He has published over 300 scientific articles (H-index 57) and is (co-)inventor of 17 patents and patent applications. Jan van Hest is also the joint founder of the start-ups Encapson, FutureChemistry, Noviosense and Noviotech.

Affiliated with

  • Gravitation program Functional Molecular Systems
  • ICMS
  • PTN (postgraduate education polymer technology the Netherlands)

Partners in (semi-)industry

  • GATT BV
  • Zoetis
  • GSK

Vingerafdruk Duik in de onderzoeksthema's waar Jan C.M. Hest, van actief is. Deze onderwerplabels komen voort uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.

  • 16 Vergelijkbare profielen
Nanoreactors Chemische stoffen
Azides Chemische stoffen
Peptides Chemische stoffen
Polymers Chemische stoffen
Cycloaddition Chemische stoffen
Self assembly Chemische stoffen
Block copolymers Chemische stoffen
Proteins Engineering en materiaalwetenschappen

Netwerk Recente externe samenwerking op landenniveau. Duik in de details door op de stippen te klikken.

Onderzoeksoutput 1992 2020

97 Citaties (Scopus)
2 Downloads (Pure)

A virus-based biocatalyst

Carette, N., Engelkamp, H., Akpa, E., Pierre, S. J., Cameron, N. R., Christianen, P. C. M., Maan, J. C., Thies, J. C., Weberskirch, R., Rowan, A. E., Nolte, R. J. M., Michon, T. & van Hest, J. C. M., apr 2007, In : Nature Nanotechnology. 2, 4, blz. 226-229 4 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Biocatalysts
viruses
Viruses
Lipases
Enzymes
307 Citaties (Scopus)
4 Downloads (Pure)

Autonomous movement of platinum-loaded stomatocytes

Wilson, D. A., Nolte, R. J. M. & van Hest, J. C. M., apr 2012, In : Nature Chemistry. 4, 4, blz. 268-274 7 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Platinum
Polymers
Nanoparticles
Monopropellants
Nanoreactors
234 Citaties (Scopus)
2 Downloads (Pure)

Cascade reactions in multicompartmentalized polymersomes

Peters, R. J. R. W., Marguet, M., Marais, S., Fraaije, M. W., van Hest, J. C. M. & Lecommandoux, S., 3 jan 2014, In : Angewandte Chemie - International Edition. 53, 1, blz. 146-150 5 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Enzymes
Nanoreactors
Thiophenes
Polystyrenes
Thiophene

CD44-targeted vesicles encapsulating granzyme B as artificial killer cells for potent inhibition of human multiple myeloma in mice

Zhong, Y., Meng, F., Zhang, W., Li, B., van Hest, J. C. M. & Zhong, Z., 10 apr 2020, In : Journal of Controlled Release. 320, blz. 421-430 10 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Artificial Cells
Granzymes
Multiple Myeloma
Bone Marrow
Neoplasms
6 Downloads (Pure)

Investigating the self-assembly and shape transformation of poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PDLLA) polymersomes by tailoring solvent-polymer interactions

Pijpers, I., Meng, F., van Hest, J. & Abdelmohsen, L., 14 jan 2020, In : Polymer Chemistry. 11, 2, blz. 275-280 6 blz.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Open Access
Bestand
Ethylene Glycol
Self assembly
Polyethylene glycols
Polymers
Organic solvents

Prijzen

Artificial endosymbiosis

J.C.M. van Hest (Ontvanger), 2015

Prijs: ERCAdvancedWetenschappelijk

symbiosis
organelles
cells
synthetic biology
uptake mechanisms

Research Center for Functional Molecular Systems

E.W. Meijer (Ontvanger), J.C.M. van Hest (Ontvanger), L. Brunsveld (Ontvanger), R.A.J. Janssen (Ontvanger) & R.P. Sijbesma (Ontvanger), 2013

Prijs: NWOZwaartekrachtWetenschappelijk

selection procedure
Ministry of Education
Netherlands
funding
science

Pers/media

ICMS Fellowship for Alex Mason

Jan C.M. Hest, van

9/01/20

1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Learning lessons in nanomedicine

Jan C.M. Hest, van

7/01/20

1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Innovative One-Health approaches in bacterial vaccine development

Jan C.M. Hest, van & Pascal Welzen

13/11/19

1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

ACADEMY SELECTS NINETEEN NEW MEMBERS

Jan C.M. Hest, van

24/04/19

1 item van Media-aandacht

Pers / media: Vakinhoudelijk commentaar

Scriptie

De synthese van amfifiele polystyreen-ionene blockcopolymeren en de toepassing als polymere cokatalysator voor de katalytische oxidatie van 1-dodecaanthiol

Auteur: van Hest, J., 31 dec 1991

Begeleider: German, A. (Afstudeerdocent 1) & Schipper, F. (Begeleider)

Scriptie/masterproef: Master

Development of reduction responsive polymersomes for controlled drug delivery

Auteur: Stam, R., 13 nov 2018

Begeleider: Pijpers, I. (Afstudeerdocent 1), van Hest, J. (Afstudeerdocent 2), Brunsveld, L. (Afstudeerdocent 2) & Abdelmohsen, L. (Afstudeerdocent 2)

Scriptie/masterproef: Master